There were 15 registrations between 21/3/2022 and 25/3/2022. There were also 6 deregistrations. These have been coordinated by the NWCFL League Registrations Secretary, Rob Goodwin-Davey.
| Club | Player Name | Date Registered | Reg Type | Role |
| AFC Darwen | Dominic Gregson | Wednesday 23rd March 2022 | Staff | Trainee Physio |
| Ashton Athletic | Samuel Twist | Monday 21st March 2022 | Non Contract | |
| Campion | Redmond Lee | Monday 21st March 2022 | Non Contract | |
| Charnock Richard | Connor Eastham | Monday 21st March 2022 | Work Experience | |
| Cheadle Town | Bevan Burey | Monday 21st March 2022 | Non Contract | |
| Cheadle Town | Adam Poole | Tuesday 22nd March 2022 | Non Contract | |
| New Mills | Kayde Coppin-Critchlow | Tuesday 22nd March 2022 | Non Contract | |
| New Mills | Louie DSouza | Monday 21st March 2022 | Non Contract | |
| New Mills | Raheem Hanley | Tuesday 22nd March 2022 | Non Contract | |
| New Mills | Ross Hannah | Tuesday 22nd March 2022 | Non Contract | |
| Prestwich Heys | Scot Cullen | Tuesday 22nd March 2022 | Contract | |
| Runcorn Town | Michael Thompson | Monday 21st March 2022 | Non Contract | |
| Squires Gate | Daniel Smith | Wednesday 23rd March 2022 | Non Contract | |
| St Martins | Luke Dulson | Wednesday 23rd March 2022 | Non Contract | |
| St Martins | Kody Jones | Tuesday 22nd March 2022 | Non Contract |
| Club | Player Name | Date De-Registered | Reg Type | Role |
| Alsager Town | Jack Flight | Wednesday 23rd March 2022 | Non Contract | |
| Alsager Town | James Flight | Wednesday 23rd March 2022 | Non Contract | |
| Longridge Town | Paul Cooper | Wednesday 23rd March 2022 | Non Contract | |
| Longridge Town | Maine Walder | Tuesday 22nd March 2022 | Work Experience | |
| Pilkington | Samuel Twist | Tuesday 22nd March 2022 | Non Contract | |
| Prestwich Heys | Scot Cullen | Monday 21st March 2022 | Non Contract |
