| Friday 7th November 2025 | Premier Division | ||
| 19:45 |  City of Liverpool v AFC Liverpool  | The Community Ground | |
| Saturday 8th November 2025 | The Isuzu FA Vase 2nd Rnd | ||
| 14:00 |  Charnock Richard v Nelson  | Mossie Park | |
| 15:00 |  Albion Sports v Holker Old Boys  | The Citadel Stadium | |
| 15:00 |  Barnoldswick Town v Winsford United  | Silentnight Stadium | |
| 15:00 |  Brigg Town v West Didsbury & Chorlton  | The EC Surfacing Stadium | |
| 15:00 |  Burscough v Ashton Town  | The Community Ground | |
| 15:00 |  Cheadle Town v North Shields  | The Ground Up Solutions Stadium | |
| 15:00 |  Crook Town v Ramsbottom United  | The Sir Tom Cowie Millfield Ground | |
| 15:00 |  Droylsden v Northwich Victoria  | The Butchers Arms | |
| 15:00 |  Liversedge v Atherton LR  | Clayborn Ground | |
| 15:00 |  Prestwich Heys v Irlam  | Adie Moran Park | |
| 15:00 |  Redcar Town v Chadderton  | Mo Mowlam Memorial Park | |
| 15:00 |  South Liverpool v Barton Town  | Jericho Lane | |
| 15:00 |  Yarm & Eaglescliffe v Fulwood Amateurs  | Sovereign Supply Chain Stadium | |
| Saturday 8th November 2025 | Premier Division | ||
| 15:00 |  Abbey Hey v Wythenshawe  | The Abbey Stadium | |
| 15:00 |  FC St Helens v Padiham  | SMS PRO SOCCER PARK | |
| 15:00 |  Longridge Town v Euxton Villa  | Inglewhite Road | |
| 15:00 |  Stockport Town v Glossop North End  | Stockport Sports Village | |
| 18:00 |  FC Isle of Man v Pilkington  | The Bowl | |
| Saturday 8th November 2025 | First Division North | ||
| 15:00 |  AFC Blackpool v Ashton Athletic  | Mechanics Ground | |
| 15:00 |  Colne v Darwen FC  | Haffners Eats Stadium | |
| 15:00 |  Garstang v Maghull  | The Riverside | |
| 15:00 |  Squires Gate v MSB Woolton  | The Skiddle Community Stadium | |
| 15:00 |  Steeton v Daisy Hill  | Marley Stadium | |
| 15:00 |  Thornton Cleveleys v Bacup Borough  | Gamble Road | |
| Saturday 8th November 2025 | First Division South | ||
| 15:00 |  Barnton v Foley Meir  | The Creative Hut Stadium | |
| 15:00 |  Cammell Laird 1907 v New Mills  | The OWS Engineering Ltd Stadium | |
| 15:00 |  Eccleshall v Ashville  | Stoke Signage Stadium | |
| 15:00 |  Market Drayton Town v Cheadle Heath Nomads  | Greenfields Sports Ground | |
| 15:00 |  Runcorn Town v Stockport Georgians  | Viridor Community Stadium | |
| 15:00 |  Sandbach United v Allscott Heath  | Sandbach Community Football Centre | |
| 15:00 |  Shawbury United v Alsager Town  | Shawbury Utd Community Sports and Recreational Centre | |
| 15:00 |  Telford Town v Wolverhampton Sporting Community  | DRM Aggregate Arena | |
| 15:00 |  Wolverhampton Casuals v Haughmond  | Brinsford Stadium | |
| Monday 10th November 2025 | First Division North | ||
| 19:45 |  Maine Road v Ashton Town | Brantingham Road | |
| Tuesday 11th November 2025 | Premier Division | ||
| 19:45 | Atherton LR v Irlam | Crilly Park | |
| 19:45 | Barnoldswick Town v Longridge Town | Silentnight Stadium | |
| 19:45 | Cheadle Town v Chadderton | The Ground Up Solutions Stadium | |
| 19:45 | Padiham v Charnock Richard | Ruby Civil Arena | |
| 19:45 | Prestwich Heys v Abbey Hey | Adie Moran Park | |
| 19:45 | Wythenshawe v Ramsbottom United | Avensure Community Stadium | |
| 20:00 | Euxton Villa v AFC Liverpool | Jim Fowler Memorial Ground | |
| Tuesday 11th November 2025 | First Division North | ||
| 19:45 | Colne v AFC Blackpool | Haffners Eats Stadium | |
| Tuesday 11th November 2025 | First Division South | ||
| 19:45 | Wolverhampton Casuals v Shawbury United | Brinsford Stadium | |
| Wednesday 12th November 2025 | The Edward Case Cup 1st Round North | ||
| 19:45 | Nelson v MSB Woolton | Jericho Lane | |
| Played at MSB Woolton | |||
| Wednesday 12th November 2025 | Premier Division | ||
| 19:45 | West Didsbury & Chorlton v City of Liverpool | Step Places Stadium | |
| Wednesday 12th November 2025 | First Division North | ||
| 20:00 | Bacup Borough v Holker Old Boys | Brian Boys West View Stadium | |
| Thursday 13th November 2025 | Cheshire Senior Cup 1st Rnd | ||
| 20:00 |  Crewe Alexandra v Barnton | Gresty Road | |
| Friday 14th November 2025 | Premier Division | ||
| 19:45 | Atherton LR v Prestwich Heys | Crilly Park | |
| 19:45 | FC St Helens v South Liverpool | SMS PRO SOCCER PARK | |
| Saturday 15th November 2025 | The Edward Case Cup 2nd Round North | ||
| 15:00 | Ashton Town v Darwen FC | The Bartons Group Stadium | |
| 15:00 |  Daisy Hill v Nelson or MSB Woolton | The Ginge Power Stadium | |
| 15:00 | Maghull v Bacup Borough | DT Hughes Community Stadium | |
| 15:00 | Maine Road v AFC Blackpool | Brantingham Road | |
| Saturday 15th November 2025 | The Edward Case Cup 2nd Round South | ||
| 15:00 | Barnton v Ashville | Ray Parker Stadium | |
| Played at Ashville | |||
| 15:00 | Runcorn Town v Stafford Town  | Viridor Community Stadium | |
| 15:00 | Sandbach United v Cheadle Heath Nomads | Sandbach Community Football Centre | |
| 15:00 | Telford Town v Stockport Georgians | DRM Aggregate Arena | |
| Saturday 15th November 2025 | Premier Division | ||
| 15:00 | AFC Liverpool v Longridge Town | Berry Street Garage Stadium | |
| 15:00 | Burscough v Glossop North End | The Community Ground | |
| 15:00 | Chadderton v City of Liverpool | Emplas Commercial North Stadium | |
| 15:00 | Charnock Richard v Cheadle Town | Mossie Park | |
| 15:00 | Irlam v Abbey Hey | The Silver St Stadium | |
| 15:00 | Ramsbottom United v Pilkington | Harry Williams Riverside Stadium | |
| 15:00 | Stockport Town v Barnoldswick Town | Stockport Sports Village | |
| 15:00 | Wythenshawe v Euxton Villa | Avensure Community Stadium | |
| 18:00 | FC Isle of Man v West Didsbury & Chorlton | The Bowl | |
| Saturday 15th November 2025 | First Division North | ||
| 15:00 | Ashton Athletic v Garstang | Brocstedes Park | |
| 15:00 | Colne v Thornton Cleveleys | Haffners Eats Stadium | |
| 15:00 | Squires Gate v Steeton | The Skiddle Community Stadium | |
| Saturday 15th November 2025 | First Division South | ||
| 15:00 | Allscott Heath v Market Drayton Town | The Giant Stadium | |
| 15:00 | Foley Meir v Shawbury United | Trentham Foods Stadium | |
| 15:00 | Haughmond v Cammell Laird 1907 | Sundorne Sports Village | |
| Monday 17th November 2025 | Cheshire Senior Cup 2nd Rnd | ||
| 19:45 | Stockport Town v Warrington Town  | Stockport Sports Village | |
| Tuesday 18th November 2025 | Premier Division | ||
| 19:45 | Barnoldswick Town v Abbey Hey | Silentnight Stadium | |
| 19:45 | Cheadle Town v Litherland REMYCA  | The Ground Up Solutions Stadium | |
| 19:45 | City of Liverpool v Ramsbottom United | The Community Ground | |
| 19:45 | Glossop North End v FC St Helens | The Asgard Engineering Stadium | |
| Tuesday 18th November 2025 | First Division South | ||
| 19:45 | Ashville v New Mills | Ray Parker Stadium | |
| 19:45 | Sandbach United v Wolverhampton Casuals | Sandbach Community Football Centre | |
| Tuesday 18th November 2025 | Cheshire Senior Cup 2nd Rnd | ||
| 19:45 | Runcorn Town v Stockport Georgians | Viridor Community Stadium | |
| Tuesday 18th November 2025 | Lancashire Challenge Trophy 2nd Rnd | ||
| 19:45 | Ashton Athletic v Lancaster City  | Brocstedes Park | |
| 19:45 | Fulwood Amateurs v AFC Fylde  | Lightfoot Green Lane | |
| 19:45 | Longridge Town v Daisy Hill | Inglewhite Road | |
| 19:45 | Prestwich Heys v Padiham | Adie Moran Park | |
| 19:45 | Squires Gate v Nelson | The Skiddle Community Stadium | |
| Tuesday 18th November 2025 | Liverpool Senior Cup Prelim Rnd | ||
| 19:45 | MSB Woolton v Bootle  | Berry Street Garage Stadium | |
| Played at Bootle | |||
| Tuesday 18th November 2025 | Manchester Premier Cup Prelim Rnd | ||
| 19:45 |  Ashton United v Chadderton | Hurst Cross | |
| 19:45 |  Radcliffe v Irlam | Stainton Park | |
| Wednesday 19th November 2025 | Lancashire Challenge Trophy 2nd Rnd | ||
| 19:45 | West Didsbury & Chorlton v Clitheroe  | Step Places Stadium | |
| 20:00 | Garstang v Wythenshawe | The Riverside | |
| Friday 21st November 2025 | The Macron Cup 3rd Rnd | ||
| 19:45 | Euxton Villa v Charnock Richard | Jim Fowler Memorial Ground | |
| 19:45 | MSB Woolton v Thornton Cleveleys | Jericho Lane | |
| Saturday 22nd November 2025 | The Macron Cup 3rd Rnd | ||
| 15:00 | Burscough v AFC Blackpool | The Community Ground | |
| 15:00 | Cammell Laird 1907 v AFC Liverpool | The OWS Engineering Ltd Stadium | |
| 15:00 | Cheadle Town v Chadderton | The Ground Up Solutions Stadium | |
| 15:00 | Ramsbottom United v West Didsbury & Chorlton | Harry Williams Riverside Stadium | |
| 15:00 | Sandbach United v Nelson | Sandbach Community Football Centre | |
| 15:00 | Telford Town v Runcorn Town | DRM Aggregate Arena | |
| Saturday 22nd November 2025 | Premier Division | ||
| 13:30 | Longridge Town v FC Isle of Man | Inglewhite Road | |
| 15:00 | Abbey Hey v Atherton LR | The Abbey Stadium | |
| 15:00 | Barnoldswick Town v FC St Helens | Silentnight Stadium | |
| 15:00 | City of Liverpool v Wythenshawe | The Community Ground | |
| 15:00 | Litherland REMYCA v Stockport Town | Litherland Sports Park | |
| 15:00 | Pilkington v Padiham | PSD Stadium | |
| 15:00 | Prestwich Heys v Glossop North End | Adie Moran Park | |
| 15:00 | South Liverpool v Irlam | Jericho Lane | |
| Saturday 22nd November 2025 | First Division North | ||
| 15:00 | Ashton Town v Fulwood Amateurs | The Bartons Group Stadium | |
| 15:00 | Bacup Borough v Squires Gate | Brian Boys West View Stadium | |
| 15:00 | Garstang v Colne | The Riverside | |
| 15:00 | Maghull v Darwen FC | DT Hughes Community Stadium | |
| 15:00 | Maine Road v Daisy Hill | Brantingham Road | |
| Saturday 22nd November 2025 | First Division South | ||
| 15:00 | Alsager Town v Cheadle Heath Nomads | Wood Park | |
| 15:00 | Ashville v Shawbury United | Ray Parker Stadium | |
| 15:00 | Barnton v Eccleshall | The Creative Hut Stadium | |
| 15:00 | New Mills v Foley Meir | Church Lane | |
| 15:00 | Wolverhampton Sporting Community v Market Drayton Town | Pride Park | |
| Monday 24th November 2025 | Manchester Premier Cup 1st Rnd | ||
| 19:45 | Maine Road v Bury  | Brantingham Road | |
| Tuesday 25th November 2025 | Premier Division | ||
| 19:45 | Chadderton v Ramsbottom United | Emplas Commercial North Stadium | |
| 19:45 | Cheadle Town v Longridge Town | The Ground Up Solutions Stadium | |
| 19:45 | Wythenshawe v South Liverpool | Avensure Community Stadium | |
| Tuesday 25th November 2025 | First Division North | ||
| 19:45 | Ashton Athletic v AFC Blackpool | Brocstedes Park | |
| Tuesday 25th November 2025 | First Division South | ||
| 19:45 | Alsager Town v Barnton | Wood Park | |
| 19:45 | Runcorn Town v Allscott Heath | Viridor Community Stadium | |
| 20:00 | Stafford Town v Sandbach United | Evans Park | |
| Tuesday 25th November 2025 | Lancashire Challenge Trophy 2nd Rnd | ||
| 19:45 |  Bamber Bridge v Thornton Cleveleys | Sir Tom Finney Stadium | |
| Tuesday 25th November 2025 | Manchester Premier Cup 1st Rnd | ||
| 19:45 |  FC United of Manchester v Abbey Hey | Broadhurst Park | |
| 19:45 |  Wythenshawe Town v Glossop North End | Ericstan Park | |
| Wednesday 26th November 2025 | Premier Division | ||
| 19:45 | Litherland REMYCA v Prestwich Heys | Litherland Sports Park | |
| Wednesday 26th November 2025 | First Division North | ||
| 19:45 | MSB Woolton v Steeton | Jericho Lane | |
| 20:00 | Nelson v Garstang | The Daisy Arena Little Wembley | |
| Wednesday 26th November 2025 | First Division South | ||
| 19:45 | Telford Town v Wolverhampton Casuals | DRM Aggregate Arena | |
| Wednesday 26th November 2025 | Manchester Premier Cup 1st Rnd | ||
| 19:45 | West Didsbury & Chorlton v Stalybridge Celtic  | Step Places Stadium | |
| Friday 28th November 2025 | Premier Division | ||
| 19:45 | FC St Helens v Litherland REMYCA | SMS PRO SOCCER PARK | |
| Friday 7th November 2025 Premier Division |
| City of Liverpool v AFC Liverpool (19:45) |
| Saturday 8th November 2025 The Isuzu FA Vase 2nd Round |
| Charnock Richard v Nelson (14:00) |
| Albion Sports v Holker Old Boys (15:00) |
| Barnoldswick Town v Winsford United (15:00) |
| Brigg Town v West Didsbury & Chorlton (15:00) |
| Burscough v Ashton Town (15:00) |
| Cheadle Town v North Shields (15:00) |
| Crook Town v Ramsbottom United (15:00) |
| Droylsden v Northwich Victoria (15:00) |
| Liversedge v Atherton LR (15:00) |
| Prestwich Heys v Irlam (15:00) |
| Redcar Town v Chadderton (15:00) |
| South Liverpool v Barton Town (15:00) |
| Yarm & Eaglescliffe v Fulwood Amateurs (15:00) |
| Saturday 8th November 2025 Premier Division |
| Abbey Hey v Wythenshawe (15:00) |
| FC St Helens v Padiham (15:00) |
| Longridge Town v Euxton Villa (15:00) |
| Stockport Town v Glossop North End (15:00) |
| FC Isle of Man v Pilkington (18:00) |
| Saturday 8th November 2025 First Division North |
| AFC Blackpool v Ashton Athletic (15:00) |
| Colne v Darwen FC (15:00) |
| Garstang v Maghull (15:00) |
| Squires Gate v MSB Woolton (15:00) |
| Steeton v Daisy Hill (15:00) |
| Thornton Cleveleys v Bacup Borough (15:00) |
| Saturday 8th November 2025 First Division South |
| Barnton v Foley Meir (15:00) |
| Cammell Laird 1907 v New Mills (15:00) |
| Eccleshall v Ashville (15:00) |
| Market Drayton Town v Cheadle Heath Nomads (15:00) |
| Runcorn Town v Stockport Georgians (15:00) |
| Sandbach United v Allscott Heath (15:00) |
| Shawbury United v Alsager Town (15:00) |
| Telford Town v Wolverhampton Sporting Community (15:00) |
| Wolverhampton Casuals v Haughmond (15:00) |
| Monday 10th November 2025 First Division North |
| Maine Road v Ashton Town (19:45) |
| Tuesday 11th November 2025 Premier Division |
| Atherton LR v Irlam (19:45) |
| Barnoldswick Town v Longridge Town (19:45) |
| Cheadle Town v Chadderton (19:45) |
| Padiham v Charnock Richard (19:45) |
| Prestwich Heys v Abbey Hey (19:45) |
| Wythenshawe v Ramsbottom United (19:45) |
| Euxton Villa v AFC Liverpool (20:00) |
| Tuesday 11th November 2025 First Division North |
| Colne v AFC Blackpool (19:45) |
| Tuesday 11th November 2025 First Division South |
| Wolverhampton Casuals v Shawbury United (19:45) |
| Wednesday 12th November 2025 The Edward Case Cup 1st Round North |
|
| Nelson v MSB Woolton (19:45) | |
| Played at MSB Woolton | |
| Wednesday 12th November 2025 Premier Division |
| West Didsbury & Chorlton v City of Liverpool (19:45) |
| Wednesday 12th November 2025 First Division North |
| Bacup Borough v Holker Old Boys (20:00) |
| Thursday 13th November 2025 Cheshire Senior Cup 1st Round |
| Crewe Alexandra v Barnton (20:00) |
| Friday 14th November 2025 Premier Division |
| Atherton LR v Prestwich Heys (19:45) |
| FC St Helens v South Liverpool (19:45) |
| Saturday 15th November 2025 The Edward Case Cup 2nd Round North |
| Ashton Town v Darwen FC (15:00) |
| Daisy Hill v Nelson or MSB Woolton (15:00) |
| Maghull v Bacup Borough (15:00) |
| Maine Road v AFC Blackpool (15:00) |
| Saturday 15th November 2025 The Edward Case Cup 2nd Round South |
|
| Barnton v Ashville (15:00) | |
| Played at Ashville | |
| Runcorn Town v Stafford Town (15:00) | |
| Sandbach United v Cheadle Heath Nomads (15:00) | |
| Telford Town v Stockport Georgians (15:00) | |
| Saturday 15th November 2025 Premier Division |
| AFC Liverpool v Longridge Town (15:00) |
| Burscough v Glossop North End (15:00) |
| Chadderton v City of Liverpool (15:00) |
| Charnock Richard v Cheadle Town (15:00) |
| Irlam v Abbey Hey (15:00) |
| Ramsbottom United v Pilkington (15:00) |
| Stockport Town v Barnoldswick Town (15:00) |
| Wythenshawe v Euxton Villa (15:00) |
| FC Isle of Man v West Didsbury & Chorlton (18:00) |
| Saturday 15th November 2025 First Division North |
| Ashton Athletic v Garstang (15:00) |
| Colne v Thornton Cleveleys (15:00) |
| Squires Gate v Steeton (15:00) |
| Saturday 15th November 2025 First Division South |
| Allscott Heath v Market Drayton Town (15:00) |
| Foley Meir v Shawbury United (15:00) |
| Haughmond v Cammell Laird 1907 (15:00) |
| Monday 17th November 2025 Cheshire Senior Cup 2nd Round |
| Stockport Town v Warrington Town (19:45) |
| Tuesday 18th November 2025 Premier Division |
| Barnoldswick Town v Abbey Hey (19:45) |
| Cheadle Town v Litherland REMYCA (19:45) |
| City of Liverpool v Ramsbottom United (19:45) |
| Glossop North End v FC St Helens (19:45) |
| Tuesday 18th November 2025 First Division South |
| Ashville v New Mills (19:45) |
| Sandbach United v Wolverhampton Casuals (19:45) |
| Tuesday 18th November 2025 Cheshire Senior Cup 2nd Round |
| Runcorn Town v Stockport Georgians (19:45) |
| Tuesday 18th November 2025 Lancashire Challenge Trophy 2nd Round |
| Ashton Athletic v Lancaster City (19:45) |
| Fulwood Amateurs v AFC Fylde (19:45) |
| Longridge Town v Daisy Hill (19:45) |
| Prestwich Heys v Padiham (19:45) |
| Squires Gate v Nelson (19:45) |
| Tuesday 18th November 2025 Liverpool Senior Cup Preliminary Round |
|
| MSB Woolton v Bootle (19:45) | |
| Played at Bootle | |
| Tuesday 18th November 2025 Manchester Premier Cup Preliminary Round |
| Ashton United v Chadderton (19:45) |
| Radcliffe v Irlam (19:45) |
| Wednesday 19th November 2025 Lancashire Challenge Trophy 2nd Round |
| West Didsbury & Chorlton v Clitheroe (19:45) |
| Garstang v Wythenshawe (20:00) |
| Friday 21st November 2025 The Macron Cup 3rd Round |
| Euxton Villa v Charnock Richard (19:45) |
| MSB Woolton v Thornton Cleveleys (19:45) |
| Saturday 22nd November 2025 The Macron Cup 3rd Round |
| Burscough v AFC Blackpool (15:00) |
| Cammell Laird 1907 v AFC Liverpool (15:00) |
| Cheadle Town v Chadderton (15:00) |
| Ramsbottom United v West Didsbury & Chorlton (15:00) |
| Sandbach United v Nelson (15:00) |
| Telford Town v Runcorn Town (15:00) |
| Saturday 22nd November 2025 Premier Division |
| Longridge Town v FC Isle of Man (13:30) |
| Abbey Hey v Atherton LR (15:00) |
| Barnoldswick Town v FC St Helens (15:00) |
| City of Liverpool v Wythenshawe (15:00) |
| Litherland REMYCA v Stockport Town (15:00) |
| Pilkington v Padiham (15:00) |
| Prestwich Heys v Glossop North End (15:00) |
| South Liverpool v Irlam (15:00) |
| Saturday 22nd November 2025 First Division North |
| Ashton Town v Fulwood Amateurs (15:00) |
| Bacup Borough v Squires Gate (15:00) |
| Garstang v Colne (15:00) |
| Maghull v Darwen FC (15:00) |
| Maine Road v Daisy Hill (15:00) |
| Saturday 22nd November 2025 First Division South |
| Alsager Town v Cheadle Heath Nomads (15:00) |
| Ashville v Shawbury United (15:00) |
| Barnton v Eccleshall (15:00) |
| New Mills v Foley Meir (15:00) |
| Wolverhampton Sporting Community v Market Drayton Town (15:00) |
| Monday 24th November 2025 Manchester Premier Cup 1st Round |
| Maine Road v Bury (19:45) |
| Tuesday 25th November 2025 Premier Division |
| Chadderton v Ramsbottom United (19:45) |
| Cheadle Town v Longridge Town (19:45) |
| Wythenshawe v South Liverpool (19:45) |
| Tuesday 25th November 2025 First Division North |
| Ashton Athletic v AFC Blackpool (19:45) |
| Tuesday 25th November 2025 First Division South |
| Alsager Town v Barnton (19:45) |
| Runcorn Town v Allscott Heath (19:45) |
| Stafford Town v Sandbach United (20:00) |
| Tuesday 25th November 2025 Lancashire Challenge Trophy 2nd Round |
| Bamber Bridge v Thornton Cleveleys (19:45) |
| Tuesday 25th November 2025 Manchester Premier Cup 1st Round |
| FC United of Manchester v Abbey Hey (19:45) |
| Wythenshawe Town v Glossop North End (19:45) |
| Wednesday 26th November 2025 Premier Division |
| Litherland REMYCA v Prestwich Heys (19:45) |
| Wednesday 26th November 2025 First Division North |
| MSB Woolton v Steeton (19:45) |
| Nelson v Garstang (20:00) |
| Wednesday 26th November 2025 First Division South |
| Telford Town v Wolverhampton Casuals (19:45) |
| Wednesday 26th November 2025 Manchester Premier Cup 1st Round |
| West Didsbury & Chorlton v Stalybridge Celtic (19:45) |
| Friday 28th November 2025 Premier Division |
| FC St Helens v Litherland REMYCA (19:45) |
