| Saturday 30th August 2025 | The Emirates F.A Cup 1st Qual Rnd | ||
| 15:00 |  Atherton LR v Atherton Collieries  | Crilly Park | |
| 15:00 |  Bishop Auckland v Chadderton  | Heritage Park | |
| 15:00 |  Hebburn Town v Longridge Town  | Hebburn Sports & Social Ground | |
| 15:00 |  West Auckland Town v Wythenshawe  | Seagraves Stadium | |
| 15:00 |  West Didsbury & Chorlton v Runcorn Linnets  | Step Places Stadium | |
| Saturday 30th August 2025 | Premier Division | ||
| 15:00 |  AFC Liverpool v City of Liverpool  | Berry Street Garage Stadium | |
| 15:00 |  Burscough v FC St Helens  | The Community Ground | |
| 15:00 |  Charnock Richard v Abbey Hey  | Mossie Park | |
| 15:00 |  Glossop North End v South Liverpool  | The Asgard Engineering Stadium | |
| 15:00 |  Litherland REMYCA v Irlam  | Litherland Sports Park | |
| 15:00 |  Pilkington v Barnoldswick Town  | PSD Stadium | |
| 15:00 |  Prestwich Heys v Cheadle Town  | Adie Moran Park | |
| 15:00 |  Stockport Town v Euxton Villa  | Stockport Sports Village | |
| 18:00 |  FC Isle of Man v Padiham  | The Bowl | |
| Saturday 30th August 2025 | First Division North | ||
| 15:00 |  Ashton Athletic v Droylsden  | Brocstedes Park | |
| 15:00 |  Ashton Town v Bacup Borough  | The Bartons Group Stadium | |
| 15:00 |  Colne v Garstang  | Haffners Eats Stadium | |
| 15:00 |  Darwen FC v AFC Blackpool  | Multevo Group Anchor Ground | |
| 15:00 |  Fulwood Amateurs v Daisy Hill  | Lightfoot Green Lane | |
| 15:00 |  MSB Woolton v Holker Old Boys  | Jericho Lane | |
| 15:00 |  Nelson v Thornton Cleveleys  | The Daisy Arena Little Wembley | |
| 15:00 |  Squires Gate v Maine Road  | The Skiddle Community Stadium | |
| 15:00 |  Steeton v Maghull  | Marley Stadium | |
| Saturday 30th August 2025 | First Division South | ||
| 15:00 |  Allscott Heath v Stafford Town  | The Giant Stadium | |
| 15:00 |  Alsager Town v Stockport Georgians  | Wood Park | |
| 15:00 |  Ashville v Telford Town  | Ray Parker Stadium | |
| 15:00 |  Cheadle Heath Nomads v Barnton  | Ideal Building Systems Stadium | |
| 15:00 |  Foley Meir v Haughmond  | Trentham Foods Stadium | |
| 15:00 |  New Mills v Eccleshall  | Church Lane | |
| 15:00 |  Sandbach United v Wolverhampton Sporting Community  | Sandbach Community Football Centre | |
| 15:00 |  Shawbury United v Runcorn Town  | Shawbury Utd Community Sports and Recreational Centre | |
| 15:00 |  Wolverhampton Casuals v Cammell Laird 1907  | Brinsford Stadium | |
| Tuesday 2nd September 2025 | Premier Division | ||
| 19:45 |  Ramsbottom United v Wythenshawe | Harry Williams Riverside Stadium | |
| Wednesday 3rd September 2025 | First Division North | ||
| 20:00 | AFC Blackpool v Ashton Town | Mechanics Ground | |
| Friday 5th September 2025 | Premier Division | ||
| 20:00 | Euxton Villa v FC St Helens | Jim Fowler Memorial Ground | |
| Saturday 6th September 2025 | Premier Division | ||
| 15:00 | Abbey Hey v Padiham | The Abbey Stadium | |
| 15:00 | Burscough v FC Isle of Man | The Community Ground | |
| 15:00 | Chadderton v Longridge Town | Emplas Commercial North Stadium | |
| 15:00 | Charnock Richard v City of Liverpool | Mossie Park | |
| 15:00 | Cheadle Town v Atherton LR | The Ground Up Solutions Stadium | |
| 15:00 | Glossop North End v Pilkington | The Asgard Engineering Stadium | |
| 15:00 | Irlam v Prestwich Heys | The Silver St Stadium | |
| 15:00 | Ramsbottom United v AFC Liverpool | Harry Williams Riverside Stadium | |
| 15:00 | South Liverpool v West Didsbury & Chorlton | Jericho Lane | |
| 15:00 | Stockport Town v Litherland REMYCA | Stockport Sports Village | |
| 15:00 | Wythenshawe v Barnoldswick Town | Avensure Community Stadium | |
| Saturday 6th September 2025 | First Division North | ||
| 15:00 | AFC Blackpool v Maine Road | Mechanics Ground | |
| 15:00 | Ashton Town v Squires Gate | The Bartons Group Stadium | |
| 15:00 | Bacup Borough v Steeton | Brian Boys West View Stadium | |
| 15:00 | Daisy Hill v Nelson | The Ginge Power Stadium | |
| 15:00 | Darwen FC v Fulwood Amateurs | Multevo Group Anchor Ground | |
| 15:00 | Droylsden v Colne | The Butchers Arms | |
| 15:00 | Garstang v MSB Woolton | The Riverside | |
| 15:00 | Holker Old Boys v Ashton Athletic | The Handmark Engineering Stadium | |
| 15:00 | Thornton Cleveleys v Maghull | Gamble Road | |
| Saturday 6th September 2025 | First Division South | ||
| 15:00 | Allscott Heath v Alsager Town | The Giant Stadium | |
| 15:00 | Cammell Laird 1907 v Telford Town | The OWS Engineering Ltd Stadium | |
| 15:00 | Cheadle Heath Nomads v Market Drayton Town  | Ideal Building Systems Stadium | |
| 15:00 | Eccleshall v Barnton | Stoke Signage Stadium | |
| 15:00 | Haughmond v Ashville | Sundorne Sports Village | |
| 15:00 | Runcorn Town v New Mills | Viridor Community Stadium | |
| 15:00 | Sandbach United v Stafford Town | Sandbach Community Football Centre | |
| 15:00 | Stockport Georgians v Shawbury United | Cromley Road | |
| 15:00 | Wolverhampton Casuals v Foley Meir | Brinsford Stadium | |
| Tuesday 9th September 2025 | Premier Division | ||
| 19:45 | AFC Liverpool v Charnock Richard | Berry Street Garage Stadium | |
| 19:45 | Atherton LR v Chadderton | Crilly Park | |
| 19:45 | Barnoldswick Town v Ramsbottom United | Silentnight Stadium | |
| 19:45 | Cheadle Town v FC Isle of Man | The Ground Up Solutions Stadium | |
| 19:45 | City of Liverpool v Irlam | The Community Ground | |
| 19:45 | Longridge Town v Litherland REMYCA | Inglewhite Road | |
| 19:45 | Padiham v Glossop North End | Ruby Civil Arena | |
| 19:45 | Prestwich Heys v West Didsbury & Chorlton | Adie Moran Park | |
| 19:45 | Wythenshawe v Abbey Hey | Avensure Community Stadium | |
| 20:00 | Euxton Villa v Burscough | Jim Fowler Memorial Ground | |
| Tuesday 9th September 2025 | First Division South | ||
| 19:45 | Alsager Town v Stafford Town | Wood Park | |
| 19:45 | Haughmond v Eccleshall | Sundorne Sports Village | |
| 19:45 | Market Drayton Town v Wolverhampton Casuals | Greenfields Sports Ground | |
| 19:45 | New Mills v Cheadle Heath Nomads | Church Lane | |
| 19:45 | Runcorn Town v Cammell Laird 1907 | Viridor Community Stadium | |
| 19:45 | Stockport Georgians v Barnton | Cromley Road | |
| 19:45 | Wolverhampton Sporting Community v Allscott Heath | Pride Park | |
| 20:00 | Foley Meir v Sandbach United | Trentham Foods Stadium | |
| Wednesday 10th September 2025 | Premier Division | ||
| 19:45 | Pilkington v Stockport Town | PSD Stadium | |
| 19:45 | South Liverpool v FC St Helens | Jericho Lane | |
| Wednesday 10th September 2025 | First Division North | ||
| 20:00 | Bacup Borough v Nelson | Brian Boys West View Stadium | |
| Wednesday 10th September 2025 | First Division South | ||
| 19:45 | Telford Town v Shawbury United | DRM Aggregate Arena | |
| Saturday 13th September 2025 | Premier Division | ||
| 15:00 | Abbey Hey v FC St Helens | The Abbey Stadium | |
| 15:00 | Burscough v Cheadle Town | The Community Ground | |
| 15:00 | Euxton Villa v Irlam | Jim Fowler Memorial Ground | |
| 15:00 | Glossop North End v Atherton LR | The Asgard Engineering Stadium | |
| 15:00 | Litherland REMYCA v Chadderton | Litherland Sports Park | |
| 15:00 | Padiham v City of Liverpool | Ruby Civil Arena | |
| 15:00 | Pilkington v Longridge Town | PSD Stadium | |
| 15:00 | Prestwich Heys v South Liverpool | Adie Moran Park | |
| 15:00 | Ramsbottom United v Stockport Town | Harry Williams Riverside Stadium | |
| 15:00 | West Didsbury & Chorlton v Barnoldswick Town | Step Places Stadium | |
| 15:00 | Wythenshawe v AFC Liverpool | Avensure Community Stadium | |
| 18:00 | FC Isle of Man v Charnock Richard | The Bowl | |
| Saturday 13th September 2025 | First Division North | ||
| 15:00 | AFC Blackpool v Garstang | Mechanics Ground | |
| 15:00 | Ashton Athletic v Nelson | Brocstedes Park | |
| 15:00 | Colne v Squires Gate | Haffners Eats Stadium | |
| 15:00 | Droylsden v Bacup Borough | The Butchers Arms | |
| 15:00 | Fulwood Amateurs v MSB Woolton | Lightfoot Green Lane | |
| 15:00 | Holker Old Boys v Ashton Town | The Handmark Engineering Stadium | |
| 15:00 | Maghull v Daisy Hill | DT Hughes Community Stadium | |
| 15:00 | Maine Road v Thornton Cleveleys | Brantingham Road | |
| 15:00 | Steeton v Darwen FC | Marley Stadium | |
| Saturday 13th September 2025 | First Division South | ||
| 15:00 | Barnton v Wolverhampton Sporting Community | The Creative Hut Stadium | |
| 15:00 | Cammell Laird 1907 v Sandbach United | The OWS Engineering Ltd Stadium | |
| 15:00 | Cheadle Heath Nomads v Alsager Town | Ideal Building Systems Stadium | |
| 15:00 | Eccleshall v Runcorn Town | Stoke Signage Stadium | |
| 15:00 | Foley Meir v New Mills | Trentham Foods Stadium | |
| 15:00 | Market Drayton Town v Allscott Heath | Greenfields Sports Ground | |
| 15:00 | Shawbury United v Ashville | Shawbury Utd Community Sports and Recreational Centre | |
| 15:00 | Stafford Town v Haughmond | Evans Park | |
| 15:00 | Wolverhampton Casuals v Stockport Georgians | Brinsford Stadium | |
| Monday 15th September 2025 | First Division South | ||
| 19:45 | Cheadle Heath Nomads v Runcorn Town | Ideal Building Systems Stadium | |
| Tuesday 16th September 2025 | Premier Division | ||
| 19:45 | AFC Liverpool v FC Isle of Man | Berry Street Garage Stadium | |
| 19:45 | Atherton LR v Litherland REMYCA | Crilly Park | |
| 19:45 | Chadderton v Euxton Villa | Emplas Commercial North Stadium | |
| 19:45 | Charnock Richard v Padiham | Mossie Park | |
| 19:45 | City of Liverpool v Pilkington | The Community Ground | |
| 19:45 | FC St Helens v Wythenshawe | SMS PRO SOCCER PARK | |
| 19:45 | Glossop North End v Prestwich Heys | The Asgard Engineering Stadium | |
| 19:45 | Irlam v West Didsbury & Chorlton | The Silver St Stadium | |
| 19:45 | Longridge Town v Barnoldswick Town | Inglewhite Road | |
| 19:45 | Ramsbottom United v Burscough | Harry Williams Riverside Stadium | |
| Tuesday 16th September 2025 | First Division South | ||
| 19:45 | Allscott Heath v Shawbury United | The Giant Stadium | |
| 19:45 | Alsager Town v Eccleshall | Wood Park | |
| 19:45 | Haughmond v Wolverhampton Casuals | Sundorne Sports Village | |
| 19:45 | New Mills v Stockport Georgians | Church Lane | |
| 19:45 | Sandbach United v Market Drayton Town | Sandbach Community Football Centre | |
| 19:45 | Wolverhampton Sporting Community v Foley Meir | Pride Park | |
| 20:00 | Stafford Town v Telford Town | Evans Park | |
| Tuesday 16th September 2025 | Lancashire Challenge Trophy 1st Rnd | ||
| 19:45 | Colne v Nelson | Haffners Eats Stadium | |
| Wednesday 17th September 2025 | Premier Division | ||
| 19:45 | South Liverpool v Abbey Hey | Jericho Lane | |
| Wednesday 17th September 2025 | First Division South | ||
| 19:45 | Barnton v Ashville | The Creative Hut Stadium | |
| Saturday 20th September 2025 | Premier Division | ||
| 15:00 | Atherton LR v FC St Helens | Crilly Park | |
| 15:00 | Litherland REMYCA v South Liverpool | Litherland Sports Park | |
| 15:00 | Pilkington v FC Isle of Man | PSD Stadium | |
| 15:00 | West Didsbury & Chorlton v Glossop North End | Step Places Stadium | |
| Saturday 20th September 2025 | First Division North | ||
| 15:00 | Ashton Athletic v MSB Woolton | Brocstedes Park | |
| 15:00 | Ashton Town v AFC Blackpool | The Bartons Group Stadium | |
| 15:00 | Maine Road v Steeton | Brantingham Road | |
| Saturday 20th September 2025 | First Division South | ||
| 15:00 | Cammell Laird 1907 v Cheadle Heath Nomads | The OWS Engineering Ltd Stadium | |
| 15:00 | Market Drayton Town v Shawbury United | Greenfields Sports Ground | |
| 15:00 | Wolverhampton Casuals v Telford Town | Brinsford Stadium | |
| Saturday 30th August 2025 The Emirates F.A Cup 1st Qualifying Round |
| Atherton LR v Atherton Collieries (15:00) |
| Bishop Auckland v Chadderton (15:00) |
| Hebburn Town v Longridge Town (15:00) |
| West Auckland Town v Wythenshawe (15:00) |
| West Didsbury & Chorlton v Runcorn Linnets (15:00) |
| Saturday 30th August 2025 Premier Division |
| AFC Liverpool v City of Liverpool (15:00) |
| Burscough v FC St Helens (15:00) |
| Charnock Richard v Abbey Hey (15:00) |
| Glossop North End v South Liverpool (15:00) |
| Litherland REMYCA v Irlam (15:00) |
| Pilkington v Barnoldswick Town (15:00) |
| Prestwich Heys v Cheadle Town (15:00) |
| Stockport Town v Euxton Villa (15:00) |
| FC Isle of Man v Padiham (18:00) |
| Saturday 30th August 2025 First Division North |
| Ashton Athletic v Droylsden (15:00) |
| Ashton Town v Bacup Borough (15:00) |
| Colne v Garstang (15:00) |
| Darwen FC v AFC Blackpool (15:00) |
| Fulwood Amateurs v Daisy Hill (15:00) |
| MSB Woolton v Holker Old Boys (15:00) |
| Nelson v Thornton Cleveleys (15:00) |
| Squires Gate v Maine Road (15:00) |
| Steeton v Maghull (15:00) |
| Saturday 30th August 2025 First Division South |
| Allscott Heath v Stafford Town (15:00) |
| Alsager Town v Stockport Georgians (15:00) |
| Ashville v Telford Town (15:00) |
| Cheadle Heath Nomads v Barnton (15:00) |
| Foley Meir v Haughmond (15:00) |
| New Mills v Eccleshall (15:00) |
| Sandbach United v Wolverhampton Sporting Community (15:00) |
| Shawbury United v Runcorn Town (15:00) |
| Wolverhampton Casuals v Cammell Laird 1907 (15:00) |
| Tuesday 2nd September 2025 Premier Division |
| Ramsbottom United v Wythenshawe (19:45) |
| Wednesday 3rd September 2025 First Division North |
| AFC Blackpool v Ashton Town (20:00) |
| Friday 5th September 2025 Premier Division |
| Euxton Villa v FC St Helens (20:00) |
| Saturday 6th September 2025 Premier Division |
| Abbey Hey v Padiham (15:00) |
| Burscough v FC Isle of Man (15:00) |
| Chadderton v Longridge Town (15:00) |
| Charnock Richard v City of Liverpool (15:00) |
| Cheadle Town v Atherton LR (15:00) |
| Glossop North End v Pilkington (15:00) |
| Irlam v Prestwich Heys (15:00) |
| Ramsbottom United v AFC Liverpool (15:00) |
| South Liverpool v West Didsbury & Chorlton (15:00) |
| Stockport Town v Litherland REMYCA (15:00) |
| Wythenshawe v Barnoldswick Town (15:00) |
| Saturday 6th September 2025 First Division North |
| AFC Blackpool v Maine Road (15:00) |
| Ashton Town v Squires Gate (15:00) |
| Bacup Borough v Steeton (15:00) |
| Daisy Hill v Nelson (15:00) |
| Darwen FC v Fulwood Amateurs (15:00) |
| Droylsden v Colne (15:00) |
| Garstang v MSB Woolton (15:00) |
| Holker Old Boys v Ashton Athletic (15:00) |
| Thornton Cleveleys v Maghull (15:00) |
| Saturday 6th September 2025 First Division South |
| Allscott Heath v Alsager Town (15:00) |
| Cammell Laird 1907 v Telford Town (15:00) |
| Cheadle Heath Nomads v Market Drayton Town (15:00) |
| Eccleshall v Barnton (15:00) |
| Haughmond v Ashville (15:00) |
| Runcorn Town v New Mills (15:00) |
| Sandbach United v Stafford Town (15:00) |
| Stockport Georgians v Shawbury United (15:00) |
| Wolverhampton Casuals v Foley Meir (15:00) |
| Tuesday 9th September 2025 Premier Division |
| AFC Liverpool v Charnock Richard (19:45) |
| Atherton LR v Chadderton (19:45) |
| Barnoldswick Town v Ramsbottom United (19:45) |
| Cheadle Town v FC Isle of Man (19:45) |
| City of Liverpool v Irlam (19:45) |
| Longridge Town v Litherland REMYCA (19:45) |
| Padiham v Glossop North End (19:45) |
| Prestwich Heys v West Didsbury & Chorlton (19:45) |
| Wythenshawe v Abbey Hey (19:45) |
| Euxton Villa v Burscough (20:00) |
| Tuesday 9th September 2025 First Division South |
| Alsager Town v Stafford Town (19:45) |
| Haughmond v Eccleshall (19:45) |
| Market Drayton Town v Wolverhampton Casuals (19:45) |
| New Mills v Cheadle Heath Nomads (19:45) |
| Runcorn Town v Cammell Laird 1907 (19:45) |
| Stockport Georgians v Barnton (19:45) |
| Wolverhampton Sporting Community v Allscott Heath (19:45) |
| Foley Meir v Sandbach United (20:00) |
| Wednesday 10th September 2025 Premier Division |
| Pilkington v Stockport Town (19:45) |
| South Liverpool v FC St Helens (19:45) |
| Wednesday 10th September 2025 First Division North |
| Bacup Borough v Nelson (20:00) |
| Wednesday 10th September 2025 First Division South |
| Telford Town v Shawbury United (19:45) |
| Saturday 13th September 2025 Premier Division |
| Abbey Hey v FC St Helens (15:00) |
| Burscough v Cheadle Town (15:00) |
| Euxton Villa v Irlam (15:00) |
| Glossop North End v Atherton LR (15:00) |
| Litherland REMYCA v Chadderton (15:00) |
| Padiham v City of Liverpool (15:00) |
| Pilkington v Longridge Town (15:00) |
| Prestwich Heys v South Liverpool (15:00) |
| Ramsbottom United v Stockport Town (15:00) |
| West Didsbury & Chorlton v Barnoldswick Town (15:00) |
| Wythenshawe v AFC Liverpool (15:00) |
| FC Isle of Man v Charnock Richard (18:00) |
| Saturday 13th September 2025 First Division North |
| AFC Blackpool v Garstang (15:00) |
| Ashton Athletic v Nelson (15:00) |
| Colne v Squires Gate (15:00) |
| Droylsden v Bacup Borough (15:00) |
| Fulwood Amateurs v MSB Woolton (15:00) |
| Holker Old Boys v Ashton Town (15:00) |
| Maghull v Daisy Hill (15:00) |
| Maine Road v Thornton Cleveleys (15:00) |
| Steeton v Darwen FC (15:00) |
| Saturday 13th September 2025 First Division South |
| Barnton v Wolverhampton Sporting Community (15:00) |
| Cammell Laird 1907 v Sandbach United (15:00) |
| Cheadle Heath Nomads v Alsager Town (15:00) |
| Eccleshall v Runcorn Town (15:00) |
| Foley Meir v New Mills (15:00) |
| Market Drayton Town v Allscott Heath (15:00) |
| Shawbury United v Ashville (15:00) |
| Stafford Town v Haughmond (15:00) |
| Wolverhampton Casuals v Stockport Georgians (15:00) |
| Monday 15th September 2025 First Division South |
| Cheadle Heath Nomads v Runcorn Town (19:45) |
| Tuesday 16th September 2025 Premier Division |
| AFC Liverpool v FC Isle of Man (19:45) |
| Atherton LR v Litherland REMYCA (19:45) |
| Chadderton v Euxton Villa (19:45) |
| Charnock Richard v Padiham (19:45) |
| City of Liverpool v Pilkington (19:45) |
| FC St Helens v Wythenshawe (19:45) |
| Glossop North End v Prestwich Heys (19:45) |
| Irlam v West Didsbury & Chorlton (19:45) |
| Longridge Town v Barnoldswick Town (19:45) |
| Ramsbottom United v Burscough (19:45) |
| Tuesday 16th September 2025 First Division South |
| Allscott Heath v Shawbury United (19:45) |
| Alsager Town v Eccleshall (19:45) |
| Haughmond v Wolverhampton Casuals (19:45) |
| New Mills v Stockport Georgians (19:45) |
| Sandbach United v Market Drayton Town (19:45) |
| Wolverhampton Sporting Community v Foley Meir (19:45) |
| Stafford Town v Telford Town (20:00) |
| Tuesday 16th September 2025 Lancashire Challenge Trophy 1st Round |
| Colne v Nelson (19:45) |
| Wednesday 17th September 2025 Premier Division |
| South Liverpool v Abbey Hey (19:45) |
| Wednesday 17th September 2025 First Division South |
| Barnton v Ashville (19:45) |
| Saturday 20th September 2025 Premier Division |
| Atherton LR v FC St Helens (15:00) |
| Litherland REMYCA v South Liverpool (15:00) |
| Pilkington v FC Isle of Man (15:00) |
| West Didsbury & Chorlton v Glossop North End (15:00) |
| Saturday 20th September 2025 First Division North |
| Ashton Athletic v MSB Woolton (15:00) |
| Ashton Town v AFC Blackpool (15:00) |
| Maine Road v Steeton (15:00) |
| Saturday 20th September 2025 First Division South |
| Cammell Laird 1907 v Cheadle Heath Nomads (15:00) |
| Market Drayton Town v Shawbury United (15:00) |
| Wolverhampton Casuals v Telford Town (15:00) |
