| Saturday 7th August 2021 | The Emirates F.A Cup Ex Prelim Rd | ||
| 15:00 |  Ashton Athletic v Squires Gate  |
Brocstedes Park | |
| 15:00 |  Athersley Recreation v Campion  |
Sheerien Park | |
| 15:00 |  Barnoldswick Town v Runcorn Town  |
Silentnight Stadium | |
| 15:00 |  Irlam v Albion Sports  |
The RG3 Digital Stadium | |
| 15:00 |  Longridge Town v Northwich Victoria  |
The Mike Riding Ground | |
| 15:00 |  Lower Breck v Penistone Church  |
Anfield Sports Community Centre | |
| 15:00 |  Macclesfield v Burscough  |
The Leasing.com Stadium | |
| 15:00 |  Padiham v AFC Liverpool  |
Ruby Civil Arena | |
| 15:00 |  Prestwich Heys v Litherland REMYCA  |
Adie Moran Park | |
| 15:00 |  Thackley v Wythenshawe Town  |
The Dennyfield | |
| 15:00 |  Vauxhall Motors v Skelmersdale United  |
The vanEupen Arena | |
| 15:00 |  West Didsbury & Chorlton v Avro  |
Step Places Stadium | |
| 15:00 |  Winsford United v Charnock Richard  |
Barton Stadium | |
| Saturday 7th August 2021 | First Division North | ||
| 15:00 |  AFC Blackpool v Cleator Moor Celtic  |
Mechanics Ground | |
| 15:00 |  Ashton Town v Ilkley Town  |
Profiles Park | |
| 15:00 |  Bury AFC v Bacup Borough  |
Neuven Stadium | |
| 15:00 |  Chadderton v Atherton LR  |
The Falcon Fire Stadium | |
| 15:00 |  Daisy Hill v Garstang  |
New Sirs | |
| 15:00 |  Golcar United v Nelson  |
Skye Direct Stadium | |
| 15:00 |  Holker Old Boys v AFC Darwen  |
The Handmark Engineering Stadium | |
| 15:00 |  St Helens Town v Pilkington  |
Arcoframe Stadium | |
| 15:00 |  Steeton v South Liverpool  |
Marley Stadium | |
| Saturday 7th August 2021 | First Division South | ||
| 14:00 |  Wythenshawe Amateurs v FC Isle of Man  |
Hollyhedge Park | |
| 15:00 |  Abbey Hulton United v Barnton  |
Drayton Beaumont Park | |
| 15:00 |  Alsager Town v Maine Road  |
Woodpark Stadium | |
| 15:00 |  Brocton v Cammell Laird 1907  |
Silkmore Lane Sports Ground | |
| 15:00 |  Cheadle Heath Nomads v Abbey Hey  |
ProSeal Stadium | |
| 15:00 |  Eccleshall v Stockport Town  |
Pershall Park | |
| 15:00 |  Ellesmere Rangers v Sandbach United  |
Beech Grove Stadium | |
| 15:00 |  Rocester v Cheadle Town  |
Hillsfield | |
| 15:00 |  St Martins v Stafford Town  |
Park Hall Stadium | |
| Sunday 8th August 2021 | The Emirates F.A Cup Ex Prelim Rd | ||
| 13:30 |  Emley AFC v Congleton Town  |
Fantastic Media Welfare Ground | |
| Tuesday 10th August 2021 | Premier Division | ||
| 19:45 | Prestwich Heys v Charnock Richard |
Adie Moran Park | |
| Tuesday 10th August 2021 | First Division South | ||
| 19:45 | West Didsbury & Chorlton v New Mills  |
Step Places Stadium | |
| Wednesday 11th August 2021 | Premier Division | ||
| 19:45 | Northwich Victoria v Wythenshawe Town |
Wincham Park | |
| Thursday 12th August 2021 | Premier Division | ||
| 20:00 | Lower Breck v Vauxhall Motors |
Anfield Sports Community Centre | |
| Saturday 14th August 2021 | Premier Division | ||
| 15:00 | AFC Liverpool v Avro |
The Marine Travel Arena | |
| 15:00 | Barnoldswick Town v Prestwich Heys |
Silentnight Stadium | |
| 15:00 | Charnock Richard v Ashton Athletic |
Mossie Park | |
| 15:00 | Lower Breck v Litherland REMYCA |
Anfield Sports Community Centre | |
| 15:00 | Macclesfield v Irlam |
The Leasing.com Stadium | |
| 15:00 | Northwich Victoria v Longridge Town |
Wincham Park | |
| 15:00 | Padiham v Squires Gate |
Ruby Civil Arena | |
| 15:00 | Runcorn Town v Skelmersdale United |
Viridor Community Stadium | |
| 15:00 | Winsford United v Burscough |
Barton Stadium | |
| 15:00 | Wythenshawe Town v Vauxhall Motors |
Ericstan Park | |
| Saturday 14th August 2021 | First Division North | ||
| 15:00 | AFC Blackpool v Nelson |
Mechanics Ground | |
| 15:00 | AFC Darwen v Daisy Hill |
WEC Group Anchor Ground | |
| 15:00 | Atherton LR v Ashton Town |
Crilly Park | |
| 15:00 | Cleator Moor Celtic v St Helens Town |
Inglenorth Park | |
| 15:00 | Ilkley Town v Holker Old Boys |
MPM Stadium | |
| 15:00 | Pilkington v Bacup Borough |
The Arcoframe Stadium | |
| 15:00 | South Liverpool v Chadderton |
Jericho Lane | |
| 15:00 | Steeton v Golcar United |
Marley Stadium | |
| Saturday 14th August 2021 | First Division South | ||
| 14:00 | Alsager Town v FC Isle of Man |
Woodpark Stadium | |
| 15:00 | Abbey Hey v Brocton |
The Abbey Stadium | |
| 15:00 | Barnton v Ellesmere Rangers |
Townfield | |
| 15:00 | Cheadle Heath Nomads v West Didsbury & Chorlton |
ProSeal Stadium | |
| 15:00 | Maine Road v Rocester |
Brantingham Road | |
| 15:00 | New Mills v Abbey Hulton United |
Church Lane | |
| 15:00 | Sandbach United v Eccleshall |
Sandbach Community Football Centre | |
| 15:00 | St Martins v Cheadle Town |
Park Hall Stadium | |
| 15:00 | Stafford Town v Cammell Laird 1907 |
Evans Park | |
| 15:00 | Stockport Town v Wythenshawe Amateurs |
Stockport Sports Village | |
| Sunday 15th August 2021 | First Division North | ||
| 15:00 | Bury AFC v Campion |
Neuven Stadium | |
| Monday 16th August 2021 | First Division North | ||
| 19:45 | Daisy Hill v South Liverpool |
New Sirs | |
| Monday 16th August 2021 | First Division South | ||
| 19:45 | Stockport Town v Cheadle Heath Nomads |
Stockport Sports Village | |
| Tuesday 17th August 2021 | Premier Division | ||
| 19:45 | AFC Liverpool v Lower Breck |
The Marine Travel Arena | |
| 19:45 | Ashton Athletic v Winsford United |
Brocstedes Park | |
| 19:45 | Charnock Richard v Skelmersdale United |
Mossie Park | |
| 19:45 | Congleton Town v Northwich Victoria |
Cheshire Silk 106.9 Stadium | |
| 19:45 | Macclesfield v Prestwich Heys |
The Leasing.com Stadium | |
| 19:45 | Runcorn Town v Wythenshawe Town |
Viridor Community Stadium | |
| 19:45 | Squires Gate v Burscough |
The Brian Addison Stadium | |
| 19:45 | Vauxhall Motors v Litherland REMYCA |
The vanEupen Arena | |
| Tuesday 17th August 2021 | First Division North | ||
| 19:45 | Ashton Town v Pilkington |
Profiles Park | |
| 19:45 | Campion v Cleator Moor Celtic |
The Players Cars Stadium | |
| 19:45 | Chadderton v Ilkley Town |
The Falcon Fire Stadium | |
| 19:45 | Golcar United v Atherton LR |
Skye Direct Stadium | |
| 19:45 | Nelson v Bury AFC |
Little Wembley | |
| 20:00 | Bacup Borough v Steeton |
Brian Boys West View Stadium | |
| Tuesday 17th August 2021 | First Division South | ||
| 19:45 | Abbey Hey v Maine Road |
The Abbey Stadium | |
| 19:45 | Alsager Town v Sandbach United |
Woodpark Stadium | |
| 19:45 | Brocton v Abbey Hulton United |
Silkmore Lane Sports Ground | |
| 19:45 | Cammell Laird 1907 v St Martins |
Prabhu Ventures Ltd Arena | |
| 19:45 | Ellesmere Rangers v Eccleshall |
Beech Grove Stadium | |
| 19:45 | Rocester v Stafford Town |
Hillsfield | |
| 19:45 | West Didsbury & Chorlton v Barnton |
Step Places Stadium | |
| 19:45 | Wythenshawe Amateurs v New Mills |
Hollyhedge Park | |
| Wednesday 18th August 2021 | Premier Division | ||
| 19:45 | Longridge Town v Barnoldswick Town |
The Mike Riding Ground | |
| 20:00 | Avro v Irlam |
Vestacare Stadium | |
| Wednesday 18th August 2021 | First Division North | ||
| 20:00 | Garstang v AFC Darwen |
The Riverside | |
| Wednesday 18th August 2021 | First Division South | ||
| 19:45 | Cheadle Town P-P FC Isle of Man |
Park Road Stadium | |
| Postponed due to Isle of Man isolation issues | |||
| Thursday 19th August 2021 | First Division North | ||
| 19:45 | St Helens Town v AFC Blackpool |
Arcoframe Stadium | |
| Friday 20th August 2021 | First Division South | ||
| 20:00 | St Martins v Alsager Town |
Park Hall Stadium | |
| Saturday 21st August 2021 | Premier Division | ||
| 15:00 | Ashton Athletic v Vauxhall Motors |
Brocstedes Park | |
| 15:00 | Burscough v Padiham |
The Community Ground | |
| 15:00 | Irlam v Barnoldswick Town |
The RG3 Digital Stadium | |
| 15:00 | Litherland REMYCA v Northwich Victoria |
Litherland Sports Park | |
| 15:00 | Longridge Town v Macclesfield |
The Mike Riding Ground | |
| 15:00 | Lower Breck v Charnock Richard |
Anfield Sports Community Centre | |
| 15:00 | Prestwich Heys v Congleton Town |
Adie Moran Park | |
| 15:00 | Skelmersdale United v AFC Liverpool |
JMO Sports Park | |
| 15:00 | Squires Gate v Avro |
The Brian Addison Stadium | |
| 15:00 | Winsford United v Runcorn Town |
Barton Stadium | |
| Saturday 21st August 2021 | First Division North | ||
| 15:00 | Ashton Town v Holker Old Boys |
Profiles Park | |
| 15:00 | Bacup Borough v AFC Blackpool |
Brian Boys West View Stadium | |
| 15:00 | Cleator Moor Celtic v Bury AFC |
Inglenorth Park | |
| 15:00 | Daisy Hill v Campion |
New Sirs | |
| 15:00 | Ilkley Town v AFC Darwen |
MPM Stadium | |
| 15:00 | Pilkington v Chadderton |
The Arcoframe Stadium | |
| 15:00 | South Liverpool v Nelson |
Jericho Lane | |
| 15:00 | Steeton v St Helens Town |
Marley Stadium | |
| Saturday 21st August 2021 | First Division South | ||
| 14:00 | Cheadle Heath Nomads v FC Isle of Man |
ProSeal Stadium | |
| 15:00 | Abbey Hulton United v Abbey Hey |
Drayton Beaumont Park | |
| 15:00 | Barnton v New Mills |
Townfield | |
| 15:00 | Cheadle Town v Wythenshawe Amateurs |
Park Road Stadium | |
| 15:00 | Eccleshall v Cammell Laird 1907 |
Pershall Park | |
| 15:00 | Ellesmere Rangers v Brocton |
Beech Grove Stadium | |
| 15:00 | Maine Road v Sandbach United |
Brantingham Road | |
| 15:00 | Rocester v Stockport Town |
Hillsfield | |
| 15:00 | Stafford Town v West Didsbury & Chorlton |
Evans Park | |
| Tuesday 24th August 2021 | First Division North | ||
| 19:45 | Garstang v Golcar United |
The Riverside | |
| Saturday 7th August 2021 The Emirates F.A Cup Ex Prelim Rd |
| Ashton Athletic v Squires Gate (15:00) |
| Athersley Rec v Campion (15:00) |
| Barnoldswick Town v Runcorn Town (15:00) |
| Irlam v Albion Sports (15:00) |
| Longridge Town v Northwich Vics (15:00) |
| Lower Breck v Penistone Chrch (15:00) |
| Macclesfield v Burscough (15:00) |
| Padiham v AFC Liverpool (15:00) |
| Prestwich Heys v Lith REMYCA (15:00) |
| Thackley v Wythenshawe Town (15:00) |
| Vauxhall Mtrs v Skelmersdale Utd (15:00) |
| West Didsbury v Avro (15:00) |
| Winsford United v Charnock Rich (15:00) |
| Saturday 7th August 2021 First Division North |
| AFC Blackpool v Cleator Moor (15:00) |
| Ashton Town v Ilkley Town (15:00) |
| Bury AFC v Bacup Borough (15:00) |
| Chadderton v Atherton LR (15:00) |
| Daisy Hill v Garstang (15:00) |
| Golcar United v Nelson (15:00) |
| Holker OB v AFC Darwen (15:00) |
| St Helens Town v Pilkington (15:00) |
| Steeton v South Liverpool (15:00) |
| Saturday 7th August 2021 First Division South |
| Wythenshawe Am v FC Isle of Man (14:00) |
| Abbey Hulton Utd v Barnton (15:00) |
| Alsager Town v Maine Road (15:00) |
| Brocton v Cammell Laird (15:00) |
| Cheadle Heath v Abbey Hey (15:00) |
| Eccleshall v Stockport Town (15:00) |
| Ellesmere Rngrs v Sandbach United (15:00) |
| Rocester v Cheadle Town (15:00) |
| St Martins v Stafford Town (15:00) |
| Sunday 8th August 2021 The Emirates F.A Cup Ex Prelim Rd |
| Emley AFC v Congleton Town (13:30) |
| Tuesday 10th August 2021 Premier Division |
| Prestwich Heys v Charnock Rich (19:45) |
| Tuesday 10th August 2021 First Division South |
| West Didsbury v New Mills (19:45) |
| Wednesday 11th August 2021 Premier Division |
| Northwich Vics v Wythenshawe Town (19:45) |
| Thursday 12th August 2021 Premier Division |
| Lower Breck v Vauxhall Mtrs (20:00) |
| Saturday 14th August 2021 Premier Division |
| AFC Liverpool v Avro (15:00) |
| Barnoldswick Town v Prestwich Heys (15:00) |
| Charnock Rich v Ashton Athletic (15:00) |
| Lower Breck v Lith REMYCA (15:00) |
| Macclesfield v Irlam (15:00) |
| Northwich Vics v Longridge Town (15:00) |
| Padiham v Squires Gate (15:00) |
| Runcorn Town v Skelmersdale Utd (15:00) |
| Winsford United v Burscough (15:00) |
| Wythenshawe Town v Vauxhall Mtrs (15:00) |
| Saturday 14th August 2021 First Division North |
| AFC Blackpool v Nelson (15:00) |
| AFC Darwen v Daisy Hill (15:00) |
| Atherton LR v Ashton Town (15:00) |
| Cleator Moor v St Helens Town (15:00) |
| Ilkley Town v Holker OB (15:00) |
| Pilkington v Bacup Borough (15:00) |
| South Liverpool v Chadderton (15:00) |
| Steeton v Golcar United (15:00) |
| Saturday 14th August 2021 First Division South |
| Alsager Town v FC Isle of Man (14:00) |
| Abbey Hey v Brocton (15:00) |
| Barnton v Ellesmere Rngrs (15:00) |
| Cheadle Heath v West Didsbury (15:00) |
| Maine Road v Rocester (15:00) |
| New Mills v Abbey Hulton Utd (15:00) |
| Sandbach United v Eccleshall (15:00) |
| St Martins v Cheadle Town (15:00) |
| Stafford Town v Cammell Laird (15:00) |
| Stockport Town v Wythenshawe Am (15:00) |
| Sunday 15th August 2021 First Division North |
| Bury AFC v Campion (15:00) |
| Monday 16th August 2021 First Division North |
| Daisy Hill v South Liverpool (19:45) |
| Monday 16th August 2021 First Division South |
| Stockport Town v Cheadle Heath (19:45) |
| Tuesday 17th August 2021 Premier Division |
| AFC Liverpool v Lower Breck (19:45) |
| Ashton Athletic v Winsford United (19:45) |
| Charnock Rich v Skelmersdale Utd (19:45) |
| Congleton Town v Northwich Vics (19:45) |
| Macclesfield v Prestwich Heys (19:45) |
| Runcorn Town v Wythenshawe Town (19:45) |
| Squires Gate v Burscough (19:45) |
| Vauxhall Mtrs v Lith REMYCA (19:45) |
| Tuesday 17th August 2021 First Division North |
| Ashton Town v Pilkington (19:45) |
| Campion v Cleator Moor (19:45) |
| Chadderton v Ilkley Town (19:45) |
| Golcar United v Atherton LR (19:45) |
| Nelson v Bury AFC (19:45) |
| Bacup Borough v Steeton (20:00) |
| Tuesday 17th August 2021 First Division South |
| Abbey Hey v Maine Road (19:45) |
| Alsager Town v Sandbach United (19:45) |
| Brocton v Abbey Hulton Utd (19:45) |
| Cammell Laird v St Martins (19:45) |
| Ellesmere Rngrs v Eccleshall (19:45) |
| Rocester v Stafford Town (19:45) |
| West Didsbury v Barnton (19:45) |
| Wythenshawe Am v New Mills (19:45) |
| Wednesday 18th August 2021 Premier Division |
| Longridge Town v Barnoldswick Town (19:45) |
| Avro v Irlam (20:00) |
| Wednesday 18th August 2021 First Division North |
| Garstang v AFC Darwen (20:00) |
| Wednesday 18th August 2021 First Division South |
|
| Cheadle Town P-P FC Isle of Man (19:45) | |
| Postponed due to Isle of Man isolation issues | |
| Thursday 19th August 2021 First Division North |
| St Helens Town v AFC Blackpool (19:45) |
| Friday 20th August 2021 First Division South |
| St Martins v Alsager Town (20:00) |
| Saturday 21st August 2021 Premier Division |
| Ashton Athletic v Vauxhall Mtrs (15:00) |
| Burscough v Padiham (15:00) |
| Irlam v Barnoldswick Town (15:00) |
| Lith REMYCA v Northwich Vics (15:00) |
| Longridge Town v Macclesfield (15:00) |
| Lower Breck v Charnock Rich (15:00) |
| Prestwich Heys v Congleton Town (15:00) |
| Skelmersdale Utd v AFC Liverpool (15:00) |
| Squires Gate v Avro (15:00) |
| Winsford United v Runcorn Town (15:00) |
| Saturday 21st August 2021 First Division North |
| Ashton Town v Holker OB (15:00) |
| Bacup Borough v AFC Blackpool (15:00) |
| Cleator Moor v Bury AFC (15:00) |
| Daisy Hill v Campion (15:00) |
| Ilkley Town v AFC Darwen (15:00) |
| Pilkington v Chadderton (15:00) |
| South Liverpool v Nelson (15:00) |
| Steeton v St Helens Town (15:00) |
| Saturday 21st August 2021 First Division South |
| Cheadle Heath v FC Isle of Man (14:00) |
| Abbey Hulton Utd v Abbey Hey (15:00) |
| Barnton v New Mills (15:00) |
| Cheadle Town v Wythenshawe Am (15:00) |
| Eccleshall v Cammell Laird (15:00) |
| Ellesmere Rngrs v Brocton (15:00) |
| Maine Road v Sandbach United (15:00) |
| Rocester v Stockport Town (15:00) |
| Stafford Town v West Didsbury (15:00) |
| Tuesday 24th August 2021 First Division North |
| Garstang v Golcar United (19:45) |
