| Saturday 9th August 2025 | Premier Division | ||
| 15:00 |  Chadderton v South Liverpool  | Emplas Commercial North Stadium | |
| 15:00 |  Charnock Richard v Irlam  | Mossie Park | |
| 15:00 |  Cheadle Town v AFC Liverpool  | The Ground Up Solutions Stadium | |
| 15:00 |  City of Liverpool v Atherton LR  | The Community Ground | |
| 15:00 |  Litherland REMYCA v Barnoldswick Town  | Litherland Sports Park | |
| 15:00 |  Longridge Town v Wythenshawe  | Inglewhite Road | |
| 15:00 |  Pilkington v Abbey Hey  | PSD Stadium | |
| 15:00 |  Ramsbottom United v FC St Helens  | Harry Williams Riverside Stadium | |
| 15:00 |  Stockport Town v Padiham  | Stockport Sports Village | |
| 15:00 |  West Didsbury & Chorlton v Euxton Villa  | Step Places Stadium | |
| 18:00 |  FC Isle of Man v Glossop North End  | The Bowl | |
| Saturday 9th August 2025 | First Division North | ||
| 15:00 |  AFC Blackpool v Maghull  | Mechanics Ground | |
| 15:00 |  Ashton Town v Daisy Hill  | The Bartons Group Stadium | |
| 15:00 |  Colne v Fulwood Amateurs  | Haffners Eats Stadium | |
| 15:00 |  Garstang v Droylsden  | The Riverside | |
| 15:00 |  Holker Old Boys v Steeton  | The Handmark Engineering Stadium | |
| 15:00 |  Maine Road v MSB Woolton  | Brantingham Road | |
| 15:00 |  Squires Gate v Darwen FC  | The Skiddle Community Stadium | |
| 15:00 |  Thornton Cleveleys v Ashton Athletic  | Gamble Road | |
| Saturday 9th August 2025 | First Division South | ||
| 15:00 |  Ashville v Stockport Georgians  | Ray Parker Stadium | |
| 15:00 |  Cheadle Heath Nomads v Cammell Laird 1907  | Ideal Building Systems Stadium | |
| 15:00 |  Eccleshall v Allscott Heath  | Stoke Signage Stadium | |
| 15:00 |  Foley Meir v Market Drayton Town  | Trentham Foods Stadium | |
| 15:00 |  Haughmond v New Mills  | Sundorne Sports Village | |
| 15:00 |  Runcorn Town v Wolverhampton Sporting Community  | Viridor Community Stadium | |
| 15:00 |  Stafford Town v Barnton  | Evans Park | |
| 15:00 |  Telford Town v Sandbach United  | DRM Aggregate Arena | |
| 15:00 |  Wolverhampton Casuals v Alsager Town  | Brinsford Stadium | |
| Monday 11th August 2025 | Premier Division | ||
| 19:45 | Stockport Town v Prestwich Heys  | Stockport Sports Village | |
| Tuesday 12th August 2025 | Premier Division | ||
| 19:45 | Abbey Hey v Ramsbottom United | The Abbey Stadium | |
| 19:45 | AFC Liverpool v FC St Helens | Berry Street Garage Stadium | |
| 19:45 | Barnoldswick Town v Chadderton | Silentnight Stadium | |
| 19:45 |  Burscough v Longridge Town | The Community Ground | |
| 19:45 | Charnock Richard v Pilkington | Mossie Park | |
| 19:45 | Cheadle Town v City of Liverpool | The Ground Up Solutions Stadium | |
| 19:45 | Glossop North End v Wythenshawe | The Asgard Engineering Stadium | |
| 19:45 | Irlam v FC Isle of Man | The Silver St Stadium | |
| 19:45 | Padiham v Euxton Villa | Ruby Civil Arena | |
| Wednesday 13th August 2025 | Premier Division | ||
| 19:45 | South Liverpool v Litherland REMYCA | Jericho Lane | |
| 19:45 | West Didsbury & Chorlton v Atherton LR | Step Places Stadium | |
| Friday 15th August 2025 | The Emirates F.A Cup Prelim Rnd | ||
| 19:45 |  Atherton Collieries v Prestwich Heys | The Kensite Stadium | |
| Saturday 16th August 2025 | The Emirates F.A Cup Prelim Rnd | ||
| 15:00 |  Congleton Town v Padiham | The Cleric Stadium | |
| 15:00 | FC St Helens v Atherton LR | SMS PRO SOCCER PARK | |
| 15:00 | Irlam v Chadderton | The Silver St Stadium | |
| 15:00 | Longridge Town v Emley  | Inglewhite Road | |
| 15:00 |  Nantwich Town v Charnock Richard | The Weaver Stadium | |
| 15:00 |  Silsden v Ramsbottom United | The Regal Interiors Stadium | |
| 15:00 | West Didsbury & Chorlton v Brighouse Town  | Step Places Stadium | |
| 15:00 |  Witton Albion v AFC Liverpool | Wincham Park | |
| 15:00 | Wythenshawe v Vauxhall Motors  | Hollyhedge Park Community Stadium | |
| Saturday 16th August 2025 | Premier Division | ||
| 15:00 | Abbey Hey v FC Isle of Man | The Abbey Stadium | |
| 15:00 | Burscough v Litherland REMYCA | The Community Ground | |
| 15:00 | Euxton Villa v Barnoldswick Town | Jim Fowler Memorial Ground | |
| 15:00 | Pilkington v South Liverpool | PSD Stadium | |
| 15:00 | Stockport Town v Cheadle Town | Stockport Sports Village | |
| Saturday 16th August 2025 | First Division North | ||
| 15:00 | AFC Blackpool v Ashton Town | Mechanics Ground | |
| 15:00 | Droylsden v Squires Gate | The Butchers Arms | |
| 15:00 | Garstang v Fulwood Amateurs | The Riverside | |
| 15:00 | Holker Old Boys v Darwen FC | The Handmark Engineering Stadium | |
| 15:00 | Maghull v Nelson  | DT Hughes Community Stadium | |
| 15:00 | Maine Road v Ashton Athletic | Brantingham Road | |
| 15:00 | MSB Woolton v Daisy Hill | Jericho Lane | |
| 15:00 | Thornton Cleveleys v Steeton | Gamble Road | |
| Saturday 16th August 2025 | First Division South | ||
| 15:00 | Alsager Town v Haughmond | Wood Park | |
| 15:00 | Barnton v Wolverhampton Casuals | The Creative Hut Stadium | |
| 15:00 | Cammell Laird 1907 v Foley Meir | The OWS Engineering Ltd Stadium | |
| 15:00 | Market Drayton Town v Ashville | Greenfields Sports Ground | |
| 15:00 | Runcorn Town v Sandbach United | Viridor Community Stadium | |
| 15:00 |  Shawbury United v Eccleshall | Shawbury Utd Community Sports and Recreational Centre | |
| 15:00 | Stockport Georgians v Allscott Heath | Cromley Road | |
| 15:00 | Telford Town v Cheadle Heath Nomads | DRM Aggregate Arena | |
| 15:00 | Wolverhampton Sporting Community v New Mills | Pride Park | |
| Sunday 17th August 2025 | The Emirates F.A Cup Prelim Rnd | ||
| 14:00 |  Hallam v City of Liverpool | Sandygate | |
| Friday 22nd August 2025 | The Isuzu FA Vase 1st Qual Rnd | ||
| 19:45 | Wythenshawe v Cheadle Heath Nomads | Hollyhedge Park Community Stadium | |
| Saturday 23rd August 2025 | Premier Division | ||
| 15:00 | AFC Liverpool v South Liverpool | Berry Street Garage Stadium | |
| 15:00 | Cheadle Town v Chadderton | The Ground Up Solutions Stadium | |
| 15:00 | Longridge Town v Atherton LR | Inglewhite Road | |
| 15:00 | Ramsbottom United v FC Isle of Man | Harry Williams Riverside Stadium | |
| 15:00 | West Didsbury & Chorlton v Irlam | Step Places Stadium | |
| Saturday 23rd August 2025 | First Division North | ||
| 15:00 | Ashton Town v Darwen FC | The Bartons Group Stadium | |
| 15:00 | Daisy Hill v Droylsden | The Ginge Power Stadium | |
| Saturday 23rd August 2025 | First Division South | ||
| 15:00 | Eccleshall v Sandbach United | Stoke Signage Stadium | |
| 15:00 | New Mills v Allscott Heath | Church Lane | |
| 15:00 | Runcorn Town v Ashville | Viridor Community Stadium | |
| Monday 25th August 2025 | Premier Division | ||
| 15:00 | Abbey Hey v Glossop North End | The Abbey Stadium | |
| 15:00 | Atherton LR v Stockport Town | Crilly Park | |
| 15:00 | Barnoldswick Town v Prestwich Heys | Silentnight Stadium | |
| 15:00 | Cheadle Town v Irlam | The Ground Up Solutions Stadium | |
| 15:00 | City of Liverpool v West Didsbury & Chorlton | The Community Ground | |
| 15:00 | Euxton Villa v Litherland REMYCA | Jim Fowler Memorial Ground | |
| 15:00 | FC St Helens v Chadderton | SMS PRO SOCCER PARK | |
| 15:00 | Longridge Town v Charnock Richard | Inglewhite Road | |
| 15:00 | Padiham v Ramsbottom United | Ruby Civil Arena | |
| 15:00 | Pilkington v AFC Liverpool | PSD Stadium | |
| 15:00 | South Liverpool v Burscough | Jericho Lane | |
| 15:00 | Wythenshawe v FC Isle of Man | Hollyhedge Park Community Stadium | |
| Tuesday 26th August 2025 | The Edward Case Cup Preliminary Round North | ||
| 19:45 | Steeton v Fulwood Amateurs | Marley Stadium | |
| Tuesday 26th August 2025 | The Edward Case Cup Preliminary Round South | ||
| 19:45 | Shawbury United v Wolverhampton Sporting Community | Shawbury Utd Community Sports and Recreational Centre | |
| 20:00 | Foley Meir v Allscott Heath | Trentham Foods Stadium | |
| Wednesday 27th August 2025 | The Edward Case Cup Preliminary Round North | ||
| 19:45 | MSB Woolton v Garstang | Jericho Lane | |
| Wednesday 27th August 2025 | The Edward Case Cup Preliminary Round South | ||
| 19:45 | Telford Town v Haughmond | DRM Aggregate Arena | |
| Saturday 30th August 2025 | Premier Division | ||
| 15:00 | Atherton LR v FC St Helens | Crilly Park | |
| 15:00 | Chadderton v Burscough | Emplas Commercial North Stadium | |
| 15:00 | Charnock Richard v Abbey Hey | Mossie Park | |
| 15:00 | City of Liverpool v Longridge Town | The Community Ground | |
| 15:00 | Glossop North End v South Liverpool | The Asgard Engineering Stadium | |
| 15:00 | Litherland REMYCA v Irlam | Litherland Sports Park | |
| 15:00 | Pilkington v Barnoldswick Town | PSD Stadium | |
| 15:00 | Prestwich Heys v Cheadle Town | Adie Moran Park | |
| 15:00 | Ramsbottom United v Wythenshawe | Harry Williams Riverside Stadium | |
| 15:00 | Stockport Town v Euxton Villa | Stockport Sports Village | |
| 15:00 | West Didsbury & Chorlton v AFC Liverpool | Step Places Stadium | |
| 18:00 | FC Isle of Man v Padiham | The Bowl | |
| Saturday 30th August 2025 | First Division North | ||
| 15:00 | Ashton Athletic v Droylsden | Brocstedes Park | |
| 15:00 | Ashton Town v Bacup Borough  | The Bartons Group Stadium | |
| 15:00 | Colne v Garstang | Haffners Eats Stadium | |
| 15:00 | Darwen FC v AFC Blackpool | Multevo Group Anchor Ground | |
| 15:00 | Fulwood Amateurs v Daisy Hill | Lightfoot Green Lane | |
| 15:00 | MSB Woolton v Holker Old Boys | Jericho Lane | |
| 15:00 | Nelson v Thornton Cleveleys | The Daisy Arena Little Wembley | |
| 15:00 | Squires Gate v Maine Road | The Skiddle Community Stadium | |
| 15:00 | Steeton v Maghull | Marley Stadium | |
| Saturday 30th August 2025 | First Division South | ||
| 15:00 | Allscott Heath v Stafford Town | The Giant Stadium | |
| 15:00 | Alsager Town v Stockport Georgians | Wood Park | |
| 15:00 | Ashville v Telford Town | Ray Parker Stadium | |
| 15:00 | Cheadle Heath Nomads v Barnton | Ideal Building Systems Stadium | |
| 15:00 | Foley Meir v Haughmond | Trentham Foods Stadium | |
| 15:00 | New Mills v Eccleshall | Church Lane | |
| 15:00 | Sandbach United v Wolverhampton Sporting Community | Sandbach Community Football Centre | |
| 15:00 | Shawbury United v Runcorn Town | Shawbury Utd Community Sports and Recreational Centre | |
| 15:00 | Wolverhampton Casuals v Cammell Laird 1907 | Brinsford Stadium | |
| Saturday 9th August 2025 Premier Division |
| Chadderton v South Liverpool (15:00) |
| Charnock Richard v Irlam (15:00) |
| Cheadle Town v AFC Liverpool (15:00) |
| City of Liverpool v Atherton LR (15:00) |
| Litherland REMYCA v Barnoldswick Town (15:00) |
| Longridge Town v Wythenshawe (15:00) |
| Pilkington v Abbey Hey (15:00) |
| Ramsbottom United v FC St Helens (15:00) |
| Stockport Town v Padiham (15:00) |
| West Didsbury & Chorlton v Euxton Villa (15:00) |
| FC Isle of Man v Glossop North End (18:00) |
| Saturday 9th August 2025 First Division North |
| AFC Blackpool v Maghull (15:00) |
| Ashton Town v Daisy Hill (15:00) |
| Colne v Fulwood Amateurs (15:00) |
| Garstang v Droylsden (15:00) |
| Holker Old Boys v Steeton (15:00) |
| Maine Road v MSB Woolton (15:00) |
| Squires Gate v Darwen FC (15:00) |
| Thornton Cleveleys v Ashton Athletic (15:00) |
| Saturday 9th August 2025 First Division South |
| Ashville v Stockport Georgians (15:00) |
| Cheadle Heath Nomads v Cammell Laird 1907 (15:00) |
| Eccleshall v Allscott Heath (15:00) |
| Foley Meir v Market Drayton Town (15:00) |
| Haughmond v New Mills (15:00) |
| Runcorn Town v Wolverhampton Sporting Community (15:00) |
| Stafford Town v Barnton (15:00) |
| Telford Town v Sandbach United (15:00) |
| Wolverhampton Casuals v Alsager Town (15:00) |
| Monday 11th August 2025 Premier Division |
| Stockport Town v Prestwich Heys (19:45) |
| Tuesday 12th August 2025 Premier Division |
| Abbey Hey v Ramsbottom United (19:45) |
| AFC Liverpool v FC St Helens (19:45) |
| Barnoldswick Town v Chadderton (19:45) |
| Burscough v Longridge Town (19:45) |
| Charnock Richard v Pilkington (19:45) |
| Cheadle Town v City of Liverpool (19:45) |
| Glossop North End v Wythenshawe (19:45) |
| Irlam v FC Isle of Man (19:45) |
| Padiham v Euxton Villa (19:45) |
| Wednesday 13th August 2025 Premier Division |
| South Liverpool v Litherland REMYCA (19:45) |
| West Didsbury & Chorlton v Atherton LR (19:45) |
| Friday 15th August 2025 The Emirates F.A Cup Preliminary Round |
| Atherton Collieries v Prestwich Heys (19:45) |
| Saturday 16th August 2025 The Emirates F.A Cup Preliminary Round |
| Congleton Town v Padiham (15:00) |
| FC St Helens v Atherton LR (15:00) |
| Irlam v Chadderton (15:00) |
| Longridge Town v Emley (15:00) |
| Nantwich Town v Charnock Richard (15:00) |
| Silsden v Ramsbottom United (15:00) |
| West Didsbury & Chorlton v Brighouse Town (15:00) |
| Witton Albion v AFC Liverpool (15:00) |
| Wythenshawe v Vauxhall Motors (15:00) |
| Saturday 16th August 2025 Premier Division |
| Abbey Hey v FC Isle of Man (15:00) |
| Burscough v Litherland REMYCA (15:00) |
| Euxton Villa v Barnoldswick Town (15:00) |
| Pilkington v South Liverpool (15:00) |
| Stockport Town v Cheadle Town (15:00) |
| Saturday 16th August 2025 First Division North |
| AFC Blackpool v Ashton Town (15:00) |
| Droylsden v Squires Gate (15:00) |
| Garstang v Fulwood Amateurs (15:00) |
| Holker Old Boys v Darwen FC (15:00) |
| Maghull v Nelson (15:00) |
| Maine Road v Ashton Athletic (15:00) |
| MSB Woolton v Daisy Hill (15:00) |
| Thornton Cleveleys v Steeton (15:00) |
| Saturday 16th August 2025 First Division South |
| Alsager Town v Haughmond (15:00) |
| Barnton v Wolverhampton Casuals (15:00) |
| Cammell Laird 1907 v Foley Meir (15:00) |
| Market Drayton Town v Ashville (15:00) |
| Runcorn Town v Sandbach United (15:00) |
| Shawbury United v Eccleshall (15:00) |
| Stockport Georgians v Allscott Heath (15:00) |
| Telford Town v Cheadle Heath Nomads (15:00) |
| Wolverhampton Sporting Community v New Mills (15:00) |
| Sunday 17th August 2025 The Emirates F.A Cup Preliminary Round |
| Hallam v City of Liverpool (14:00) |
| Friday 22nd August 2025 The Isuzu FA Vase 1st Qualifying Round |
| Wythenshawe v Cheadle Heath Nomads (19:45) |
| Saturday 23rd August 2025 Premier Division |
| AFC Liverpool v South Liverpool (15:00) |
| Cheadle Town v Chadderton (15:00) |
| Longridge Town v Atherton LR (15:00) |
| Ramsbottom United v FC Isle of Man (15:00) |
| West Didsbury & Chorlton v Irlam (15:00) |
| Saturday 23rd August 2025 First Division North |
| Ashton Town v Darwen FC (15:00) |
| Daisy Hill v Droylsden (15:00) |
| Saturday 23rd August 2025 First Division South |
| Eccleshall v Sandbach United (15:00) |
| New Mills v Allscott Heath (15:00) |
| Runcorn Town v Ashville (15:00) |
| Monday 25th August 2025 Premier Division |
| Abbey Hey v Glossop North End (15:00) |
| Atherton LR v Stockport Town (15:00) |
| Barnoldswick Town v Prestwich Heys (15:00) |
| Cheadle Town v Irlam (15:00) |
| City of Liverpool v West Didsbury & Chorlton (15:00) |
| Euxton Villa v Litherland REMYCA (15:00) |
| FC St Helens v Chadderton (15:00) |
| Longridge Town v Charnock Richard (15:00) |
| Padiham v Ramsbottom United (15:00) |
| Pilkington v AFC Liverpool (15:00) |
| South Liverpool v Burscough (15:00) |
| Wythenshawe v FC Isle of Man (15:00) |
| Tuesday 26th August 2025 The Edward Case Cup Preliminary Round North |
| Steeton v Fulwood Amateurs (19:45) |
| Tuesday 26th August 2025 The Edward Case Cup Preliminary Round South |
| Shawbury United v Wolverhampton Sporting Community (19:45) |
| Foley Meir v Allscott Heath (20:00) |
| Wednesday 27th August 2025 The Edward Case Cup Preliminary Round North |
| MSB Woolton v Garstang (19:45) |
| Wednesday 27th August 2025 The Edward Case Cup Preliminary Round South |
| Telford Town v Haughmond (19:45) |
| Saturday 30th August 2025 Premier Division |
| Atherton LR v FC St Helens (15:00) |
| Chadderton v Burscough (15:00) |
| Charnock Richard v Abbey Hey (15:00) |
| City of Liverpool v Longridge Town (15:00) |
| Glossop North End v South Liverpool (15:00) |
| Litherland REMYCA v Irlam (15:00) |
| Pilkington v Barnoldswick Town (15:00) |
| Prestwich Heys v Cheadle Town (15:00) |
| Ramsbottom United v Wythenshawe (15:00) |
| Stockport Town v Euxton Villa (15:00) |
| West Didsbury & Chorlton v AFC Liverpool (15:00) |
| FC Isle of Man v Padiham (18:00) |
| Saturday 30th August 2025 First Division North |
| Ashton Athletic v Droylsden (15:00) |
| Ashton Town v Bacup Borough (15:00) |
| Colne v Garstang (15:00) |
| Darwen FC v AFC Blackpool (15:00) |
| Fulwood Amateurs v Daisy Hill (15:00) |
| MSB Woolton v Holker Old Boys (15:00) |
| Nelson v Thornton Cleveleys (15:00) |
| Squires Gate v Maine Road (15:00) |
| Steeton v Maghull (15:00) |
| Saturday 30th August 2025 First Division South |
| Allscott Heath v Stafford Town (15:00) |
| Alsager Town v Stockport Georgians (15:00) |
| Ashville v Telford Town (15:00) |
| Cheadle Heath Nomads v Barnton (15:00) |
| Foley Meir v Haughmond (15:00) |
| New Mills v Eccleshall (15:00) |
| Sandbach United v Wolverhampton Sporting Community (15:00) |
| Shawbury United v Runcorn Town (15:00) |
| Wolverhampton Casuals v Cammell Laird 1907 (15:00) |
