| Saturday 4th October 2025 | Premier Division | ||
| 15:00 |  Abbey Hey v Euxton Villa  | The Abbey Stadium | |
| 15:00 |  Atherton LR v AFC Liverpool  | Crilly Park | |
| 15:00 |  Burscough v City of Liverpool  | The Community Ground | |
| 15:00 |  Charnock Richard v FC St Helens  | Mossie Park | |
| 15:00 |  Glossop North End v Chadderton  | The Asgard Engineering Stadium | |
| 15:00 |  Litherland REMYCA v Padiham  | Litherland Sports Park | |
| 15:00 |  Pilkington v Cheadle Town  | PSD Stadium | |
| 15:00 |  Ramsbottom United v Prestwich Heys  | Harry Williams Riverside Stadium | |
| 15:00 |  Stockport Town v Irlam  | Stockport Sports Village | |
| 15:00 |  West Didsbury & Chorlton v Longridge Town  | Step Places Stadium | |
| 15:00 |  Wythenshawe v South Liverpool  | Avensure Community Stadium | |
| 18:00 |  FC Isle of Man v Barnoldswick Town  | The Bowl | |
| Saturday 4th October 2025 | First Division North | ||
| 15:00 |  Ashton Athletic v AFC Blackpool  | Brocstedes Park | |
| 15:00 |  Daisy Hill v Colne  | The Ginge Power Stadium | |
| 15:00 |  Darwen FC v Maghull  | Multevo Group Anchor Ground | |
| 15:00 |  Garstang v Ashton Town  | The Riverside | |
| 15:00 |  Maine Road v Bacup Borough  | Brantingham Road | |
| 15:00 |  MSB Woolton v Steeton  | Jericho Lane | |
| 15:00 |  Nelson v Fulwood Amateurs  | The Daisy Arena Little Wembley | |
| 15:00 |  Squires Gate v Holker Old Boys  | The Skiddle Community Stadium | |
| 15:00 |  Thornton Cleveleys v Droylsden  | Gamble Road | |
| Saturday 4th October 2025 | First Division South | ||
| 15:00 |  Allscott Heath v Haughmond  | The Giant Stadium | |
| 15:00 |  Ashville v Cheadle Heath Nomads  | Ray Parker Stadium | |
| 15:00 |  Eccleshall v Telford Town  | Stoke Signage Stadium | |
| 15:00 |  Market Drayton Town v Stafford Town  | Greenfields Sports Ground | |
| 15:00 |  New Mills v Cammell Laird 1907  | Church Lane | |
| 15:00 |  Runcorn Town v Foley Meir  | Viridor Community Stadium | |
| 15:00 |  Shawbury United v Barnton  | Shawbury Utd Community Sports and Recreational Centre | |
| 15:00 |  Stockport Georgians v Sandbach United  | Cromley Road | |
| 15:00 |  Wolverhampton Sporting Community v Alsager Town  | Pride Park | |
| Tuesday 7th October 2025 | Premier Division | ||
| 19:45 | Burscough v Pilkington | The Community Ground | |
| 19:45 | Chadderton v Abbey Hey | Emplas Commercial North Stadium | |
| 19:45 | FC St Helens v Prestwich Heys | SMS PRO SOCCER PARK | |
| 19:45 | Glossop North End v Stockport Town | The Asgard Engineering Stadium | |
| 19:45 | Irlam v Atherton LR | The Silver St Stadium | |
| 19:45 | Padiham v Longridge Town | Ruby Civil Arena | |
| 19:45 | Ramsbottom United v Charnock Richard | Harry Williams Riverside Stadium | |
| 19:45 | Wythenshawe v Cheadle Town | Avensure Community Stadium | |
| Tuesday 7th October 2025 | First Division North | ||
| 19:45 | Ashton Town v Maghull | The Bartons Group Stadium | |
| 19:45 | Droylsden v MSB Woolton | The Butchers Arms | |
| Tuesday 7th October 2025 | Cheshire Senior Cup 1st Rnd | ||
| 19:45 | Ashville v Cheadle Heath Nomads | Ray Parker Stadium | |
| 19:45 |  Chester FC v Alsager Town | Swansway Chester Stadium | |
| Tuesday 7th October 2025 | Liverpool Senior Cup Prelim Rnd | ||
| 19:45 | AFC Liverpool v Runcorn Town | Berry Street Garage Stadium | |
| Tuesday 7th October 2025 | Staffordshire Senior Cup 1st Rnd | ||
| 19:45 | Stafford Town v Stoke City  | Evans Park | |
| Tuesday 7th October 2025 | TJ Vickers Premier Cup QF | ||
| 19:45 | Haughmond v Telford Town | Sundorne Sports Village | |
| 19:45 | Shawbury United v Market Drayton Town | Shawbury Utd Community Sports and Recreational Centre | |
| Wednesday 8th October 2025 | Premier Division | ||
| 19:45 | South Liverpool v FC Isle of Man | Jericho Lane | |
| 19:45 | West Didsbury & Chorlton v Litherland REMYCA | Step Places Stadium | |
| Wednesday 8th October 2025 | First Division North | ||
| 20:00 | Bacup Borough v Fulwood Amateurs | Brian Boys West View Stadium | |
| Wednesday 8th October 2025 | TJ Vickers Premier Cup QF | ||
| 19:45 | Allscott Heath v Whitchurch Alport  | The Giant Stadium | |
| Friday 10th October 2025 | The Macron Cup 2nd Rnd | ||
| 19:45 | AFC Liverpool v Maghull | Berry Street Garage Stadium | |
| Saturday 11th October 2025 | The Macron Cup 2nd Rnd | ||
| 15:00 | AFC Blackpool v Barnoldswick Town | Mechanics Ground | |
| 15:00 | Atherton LR v Burscough | Crilly Park | |
| 15:00 | Cammell Laird 1907 v Wolverhampton Casuals  | The OWS Engineering Ltd Stadium | |
| 15:00 | City of Liverpool v Charnock Richard | The Community Ground | |
| 15:00 | Colne v Euxton Villa | Haffners Eats Stadium | |
| 15:00 | Eccleshall v Telford Town | Stoke Signage Stadium | |
| 15:00 | FC St Helens v MSB Woolton | SMS PRO SOCCER PARK | |
| 15:00 | Foley Meir v Sandbach United | Trentham Foods Stadium | |
| 15:00 | Garstang v Thornton Cleveleys | The Riverside | |
| 15:00 | Maine Road v Cheadle Town | Brantingham Road | |
| 15:00 | New Mills v Chadderton | Church Lane | |
| 15:00 | Padiham v Nelson | Ruby Civil Arena | |
| 15:00 | Ramsbottom United v Prestwich Heys | Harry Williams Riverside Stadium | |
| 15:00 | Runcorn Town v Allscott Heath | Viridor Community Stadium | |
| 15:00 | West Didsbury & Chorlton v Abbey Hey | Step Places Stadium | |
| Saturday 11th October 2025 | Premier Division | ||
| 15:00 | Litherland REMYCA v FC Isle of Man | Litherland Sports Park | |
| 15:00 | Longridge Town v South Liverpool | Inglewhite Road | |
| 15:00 | Pilkington v Glossop North End | PSD Stadium | |
| 15:00 | Wythenshawe v Stockport Town | Avensure Community Stadium | |
| Saturday 11th October 2025 | First Division North | ||
| 15:00 | Ashton Athletic v Bacup Borough | Brocstedes Park | |
| 15:00 | Ashton Town v Steeton | The Bartons Group Stadium | |
| 15:00 | Daisy Hill v Darwen FC | The Ginge Power Stadium | |
| 15:00 | Droylsden v Holker Old Boys | The Butchers Arms | |
| 15:00 | Squires Gate v Fulwood Amateurs | The Skiddle Community Stadium | |
| Saturday 11th October 2025 | First Division South | ||
| 15:00 | Cheadle Heath Nomads v Shawbury United | Ideal Building Systems Stadium | |
| 15:00 | Haughmond v Barnton | Sundorne Sports Village | |
| 15:00 | Market Drayton Town v Alsager Town | Greenfields Sports Ground | |
| 15:00 | Stafford Town v Ashville | Evans Park | |
| 15:00 | Stockport Georgians v Wolverhampton Sporting Community | Cromley Road | |
| Monday 13th October 2025 | Cheshire Senior Cup 1st Rnd | ||
| 19:45 | Stockport Town v Hyde United  | Stockport Sports Village | |
| Tuesday 14th October 2025 | Premier Division | ||
| 19:45 | Atherton LR v Wythenshawe | Crilly Park | |
| 19:45 | Barnoldswick Town v Ramsbottom United | Silentnight Stadium | |
| 19:45 | Charnock Richard v West Didsbury & Chorlton | Mossie Park | |
| 19:45 | FC St Helens v Irlam | SMS PRO SOCCER PARK | |
| 19:45 | Prestwich Heys v Pilkington | Adie Moran Park | |
| Tuesday 14th October 2025 | First Division South | ||
| 19:45 | Alsager Town v Runcorn Town | Wood Park | |
| Tuesday 14th October 2025 | Cheshire Senior Cup 1st Rnd | ||
| 19:45 |  1874 Northwich v Cheadle Town | Townfield Stadium | |
| Tuesday 14th October 2025 | Liverpool Senior Cup Prelim Rnd | ||
| 19:45 | Burscough v Ashton Town | The Community Ground | |
| 19:45 | Maghull v Warrington Rylands 1906  | DT Hughes Community Stadium | |
| Wednesday 15th October 2025 | Premier Division | ||
| 19:45 | Litherland REMYCA v Chadderton | Litherland Sports Park | |
| 19:45 | South Liverpool v Euxton Villa | Jericho Lane | |
| Wednesday 15th October 2025 | First Division North | ||
| 20:00 | Bacup Borough v Colne | Brian Boys West View Stadium | |
| Saturday 18th October 2025 | The Edward Case Cup 1st Round South | ||
| 15:00 | Ashville v Wolverhampton Casuals | Ray Parker Stadium | |
| Saturday 18th October 2025 | Premier Division | ||
| 15:00 | Atherton LR v West Didsbury & Chorlton | Crilly Park | |
| 15:00 | Longridge Town v Glossop North End | Inglewhite Road | |
| 15:00 | Padiham v Litherland REMYCA | Ruby Civil Arena | |
| 15:00 | Pilkington v City of Liverpool | PSD Stadium | |
| 15:00 | Stockport Town v Abbey Hey | Stockport Sports Village | |
| 18:00 | FC Isle of Man v FC St Helens | The Bowl | |
| Saturday 18th October 2025 | First Division North | ||
| 15:00 | Bacup Borough v MSB Woolton | Brian Boys West View Stadium | |
| 15:00 | Daisy Hill v Maine Road | The Ginge Power Stadium | |
| 15:00 | Garstang v Thornton Cleveleys | The Riverside | |
| 15:00 | Maghull v Steeton | DT Hughes Community Stadium | |
| 15:00 | Squires Gate v Ashton Athletic | The Skiddle Community Stadium | |
| Saturday 18th October 2025 | First Division South | ||
| 15:00 | Cammell Laird 1907 v Allscott Heath | The OWS Engineering Ltd Stadium | |
| 15:00 | Cheadle Heath Nomads v Eccleshall | Ideal Building Systems Stadium | |
| 15:00 | Foley Meir v Stockport Georgians | Trentham Foods Stadium | |
| 15:00 | Haughmond v Wolverhampton Sporting Community | Sundorne Sports Village | |
| 15:00 | Sandbach United v Barnton | Sandbach Community Football Centre | |
| 15:00 | Telford Town v Market Drayton Town | DRM Aggregate Arena | |
| Monday 20th October 2025 | Premier Division | ||
| 19:45 | Stockport Town v City of Liverpool | Stockport Sports Village | |
| Monday 20th October 2025 | First Division South | ||
| 19:45 | Cheadle Heath Nomads v New Mills | Ideal Building Systems Stadium | |
| Tuesday 21st October 2025 | Premier Division | ||
| 19:45 | Abbey Hey v Prestwich Heys | The Abbey Stadium | |
| 19:45 | Burscough v Euxton Villa | The Community Ground | |
| 19:45 | Chadderton v Padiham | Emplas Commercial North Stadium | |
| 19:45 | Charnock Richard v AFC Liverpool | Mossie Park | |
| 19:45 | Cheadle Town v Longridge Town | The Ground Up Solutions Stadium | |
| 19:45 | Irlam v Barnoldswick Town | The Silver St Stadium | |
| 19:45 | Ramsbottom United v Glossop North End | Harry Williams Riverside Stadium | |
| 19:45 | Wythenshawe v FC St Helens | Avensure Community Stadium | |
| Tuesday 21st October 2025 | First Division North | ||
| 19:45 | Steeton v Nelson | Marley Stadium | |
| Tuesday 21st October 2025 | First Division South | ||
| 19:45 | Allscott Heath v Wolverhampton Sporting Community | The Giant Stadium | |
| 19:45 | Cammell Laird 1907 v Barnton | The OWS Engineering Ltd Stadium | |
| 19:45 | Market Drayton Town v Haughmond | Greenfields Sports Ground | |
| 19:45 | Runcorn Town v Ashville | Viridor Community Stadium | |
| 19:45 | Shawbury United v Stafford Town | Shawbury Utd Community Sports and Recreational Centre | |
| 20:00 | Foley Meir v Alsager Town | Trentham Foods Stadium | |
| Wednesday 22nd October 2025 | First Division South | ||
| 19:45 | Eccleshall v Sandbach United | Stoke Signage Stadium | |
| Saturday 4th October 2025 Premier Division |
| Abbey Hey v Euxton Villa (15:00) |
| Atherton LR v AFC Liverpool (15:00) |
| Burscough v City of Liverpool (15:00) |
| Charnock Richard v FC St Helens (15:00) |
| Glossop North End v Chadderton (15:00) |
| Litherland REMYCA v Padiham (15:00) |
| Pilkington v Cheadle Town (15:00) |
| Ramsbottom United v Prestwich Heys (15:00) |
| Stockport Town v Irlam (15:00) |
| West Didsbury & Chorlton v Longridge Town (15:00) |
| Wythenshawe v South Liverpool (15:00) |
| FC Isle of Man v Barnoldswick Town (18:00) |
| Saturday 4th October 2025 First Division North |
| Ashton Athletic v AFC Blackpool (15:00) |
| Daisy Hill v Colne (15:00) |
| Darwen FC v Maghull (15:00) |
| Garstang v Ashton Town (15:00) |
| Maine Road v Bacup Borough (15:00) |
| MSB Woolton v Steeton (15:00) |
| Nelson v Fulwood Amateurs (15:00) |
| Squires Gate v Holker Old Boys (15:00) |
| Thornton Cleveleys v Droylsden (15:00) |
| Saturday 4th October 2025 First Division South |
| Allscott Heath v Haughmond (15:00) |
| Ashville v Cheadle Heath Nomads (15:00) |
| Eccleshall v Telford Town (15:00) |
| Market Drayton Town v Stafford Town (15:00) |
| New Mills v Cammell Laird 1907 (15:00) |
| Runcorn Town v Foley Meir (15:00) |
| Shawbury United v Barnton (15:00) |
| Stockport Georgians v Sandbach United (15:00) |
| Wolverhampton Sporting Community v Alsager Town (15:00) |
| Tuesday 7th October 2025 Premier Division |
| Burscough v Pilkington (19:45) |
| Chadderton v Abbey Hey (19:45) |
| FC St Helens v Prestwich Heys (19:45) |
| Glossop North End v Stockport Town (19:45) |
| Irlam v Atherton LR (19:45) |
| Padiham v Longridge Town (19:45) |
| Ramsbottom United v Charnock Richard (19:45) |
| Wythenshawe v Cheadle Town (19:45) |
| Tuesday 7th October 2025 First Division North |
| Ashton Town v Maghull (19:45) |
| Droylsden v MSB Woolton (19:45) |
| Tuesday 7th October 2025 Cheshire Senior Cup 1st Round |
| Ashville v Cheadle Heath Nomads (19:45) |
| Chester FC v Alsager Town (19:45) |
| Tuesday 7th October 2025 Liverpool Senior Cup Preliminary Round |
| AFC Liverpool v Runcorn Town (19:45) |
| Tuesday 7th October 2025 Staffordshire Senior Cup 1st Round |
| Stafford Town v Stoke City (19:45) |
| Tuesday 7th October 2025 TJ Vickers Premier Cup Quarter Finals |
| Haughmond v Telford Town (19:45) |
| Shawbury United v Market Drayton Town (19:45) |
| Wednesday 8th October 2025 Premier Division |
| South Liverpool v FC Isle of Man (19:45) |
| West Didsbury & Chorlton v Litherland REMYCA (19:45) |
| Wednesday 8th October 2025 First Division North |
| Bacup Borough v Fulwood Amateurs (20:00) |
| Wednesday 8th October 2025 TJ Vickers Premier Cup Quarter Finals |
| Allscott Heath v Whitchurch Alport (19:45) |
| Friday 10th October 2025 The Macron Cup 2nd Round |
| AFC Liverpool v Maghull (19:45) |
| Saturday 11th October 2025 The Macron Cup 2nd Round |
| AFC Blackpool v Barnoldswick Town (15:00) |
| Atherton LR v Burscough (15:00) |
| Cammell Laird 1907 v Wolverhampton Casuals (15:00) |
| City of Liverpool v Charnock Richard (15:00) |
| Colne v Euxton Villa (15:00) |
| Eccleshall v Telford Town (15:00) |
| FC St Helens v MSB Woolton (15:00) |
| Foley Meir v Sandbach United (15:00) |
| Garstang v Thornton Cleveleys (15:00) |
| Maine Road v Cheadle Town (15:00) |
| New Mills v Chadderton (15:00) |
| Padiham v Nelson (15:00) |
| Ramsbottom United v Prestwich Heys (15:00) |
| Runcorn Town v Allscott Heath (15:00) |
| West Didsbury & Chorlton v Abbey Hey (15:00) |
| Saturday 11th October 2025 Premier Division |
| Litherland REMYCA v FC Isle of Man (15:00) |
| Longridge Town v South Liverpool (15:00) |
| Pilkington v Glossop North End (15:00) |
| Wythenshawe v Stockport Town (15:00) |
| Saturday 11th October 2025 First Division North |
| Ashton Athletic v Bacup Borough (15:00) |
| Ashton Town v Steeton (15:00) |
| Daisy Hill v Darwen FC (15:00) |
| Droylsden v Holker Old Boys (15:00) |
| Squires Gate v Fulwood Amateurs (15:00) |
| Saturday 11th October 2025 First Division South |
| Cheadle Heath Nomads v Shawbury United (15:00) |
| Haughmond v Barnton (15:00) |
| Market Drayton Town v Alsager Town (15:00) |
| Stafford Town v Ashville (15:00) |
| Stockport Georgians v Wolverhampton Sporting Community (15:00) |
| Monday 13th October 2025 Cheshire Senior Cup 1st Round |
| Stockport Town v Hyde United (19:45) |
| Tuesday 14th October 2025 Premier Division |
| Atherton LR v Wythenshawe (19:45) |
| Barnoldswick Town v Ramsbottom United (19:45) |
| Charnock Richard v West Didsbury & Chorlton (19:45) |
| FC St Helens v Irlam (19:45) |
| Prestwich Heys v Pilkington (19:45) |
| Tuesday 14th October 2025 First Division South |
| Alsager Town v Runcorn Town (19:45) |
| Tuesday 14th October 2025 Cheshire Senior Cup 1st Round |
| 1874 Northwich v Cheadle Town (19:45) |
| Tuesday 14th October 2025 Liverpool Senior Cup Preliminary Round |
| Burscough v Ashton Town (19:45) |
| Maghull v Warrington Rylands 1906 (19:45) |
| Wednesday 15th October 2025 Premier Division |
| Litherland REMYCA v Chadderton (19:45) |
| South Liverpool v Euxton Villa (19:45) |
| Wednesday 15th October 2025 First Division North |
| Bacup Borough v Colne (20:00) |
| Saturday 18th October 2025 The Isuzu FA Vase 1st Round |
| Ashton Town v Darwen FC (15:00) |
| Barnoldswick Town v AFC Liverpool (15:00) |
| Burscough v Billingham Synthonia (15:00) |
| Eccleshill United v Chadderton (15:00) |
| Euxton Villa v Carlisle City (15:00) |
| Horbury Town v Charnock Richard (15:00) |
| Irlam v Shildon (15:00) |
| Nelson v Harrogate Railway Athletic (15:00) |
| Northallerton Town v South Liverpool (15:00) |
| Penistone Church v Droylsden (15:00) |
| Prestwich Heys v Maltby Main (15:00) |
| Ramsbottom United v Jarrow FC (15:00) |
| Runcorn Town v Fulwood Amateurs (15:00) |
| Stafford Town v Nuneaton Town (15:00) |
| West Allotment Celtic v Cheadle Town (15:00) |
| Wythenshawe v Holker Old Boys (15:00) |
| Yarm & Eaglescliffe v Colne (15:00) |
| Saturday 18th October 2025 The Edward Case Cup 1st Round South |
| Ashville v Wolverhampton Casuals (15:00) |
| Saturday 18th October 2025 Premier Division |
| Atherton LR v West Didsbury & Chorlton (15:00) |
| Longridge Town v Glossop North End (15:00) |
| Padiham v Litherland REMYCA (15:00) |
| Pilkington v City of Liverpool (15:00) |
| Stockport Town v Abbey Hey (15:00) |
| FC Isle of Man v FC St Helens (18:00) |
| Saturday 18th October 2025 First Division North |
| Bacup Borough v MSB Woolton (15:00) |
| Daisy Hill v Maine Road (15:00) |
| Garstang v Thornton Cleveleys (15:00) |
| Maghull v Steeton (15:00) |
| Squires Gate v Ashton Athletic (15:00) |
| Saturday 18th October 2025 First Division South |
| Cammell Laird 1907 v Allscott Heath (15:00) |
| Cheadle Heath Nomads v Eccleshall (15:00) |
| Foley Meir v Stockport Georgians (15:00) |
| Haughmond v Wolverhampton Sporting Community (15:00) |
| Sandbach United v Barnton (15:00) |
| Telford Town v Market Drayton Town (15:00) |
| Monday 20th October 2025 Premier Division |
| Stockport Town v City of Liverpool (19:45) |
| Monday 20th October 2025 First Division South |
| Cheadle Heath Nomads v New Mills (19:45) |
| Tuesday 21st October 2025 Premier Division |
| Abbey Hey v Prestwich Heys (19:45) |
| Burscough v Euxton Villa (19:45) |
| Chadderton v Padiham (19:45) |
| Charnock Richard v AFC Liverpool (19:45) |
| Cheadle Town v Longridge Town (19:45) |
| Irlam v Barnoldswick Town (19:45) |
| Ramsbottom United v Glossop North End (19:45) |
| Wythenshawe v FC St Helens (19:45) |
| Tuesday 21st October 2025 First Division North |
| Steeton v Nelson (19:45) |
| Tuesday 21st October 2025 First Division South |
| Allscott Heath v Wolverhampton Sporting Community (19:45) |
| Cammell Laird 1907 v Barnton (19:45) |
| Market Drayton Town v Haughmond (19:45) |
| Runcorn Town v Ashville (19:45) |
| Shawbury United v Stafford Town (19:45) |
| Foley Meir v Alsager Town (20:00) |
| Wednesday 22nd October 2025 First Division South |
| Eccleshall v Sandbach United (19:45) |
