| Friday 14th November 2025 | Premier Division | ||
| 19:45 |  Atherton LR v Prestwich Heys  | Crilly Park | |
| 19:45 |  FC St Helens v South Liverpool  | SMS PRO SOCCER PARK | |
| Saturday 15th November 2025 | The Edward Case Cup 2nd Round North | ||
| 15:00 |  Ashton Town v Darwen FC  | The Bartons Group Stadium | |
| 15:00 |  Daisy Hill v Nelson  | The Ginge Power Stadium | |
| 15:00 | Daisy Hill v Nelson | The Ginge Power Stadium | |
| 15:00 |  Maghull v Bacup Borough  | DT Hughes Community Stadium | |
| 15:00 |  Maine Road v AFC Blackpool  | Brantingham Road | |
| Saturday 15th November 2025 | The Edward Case Cup 2nd Round South | ||
| 15:00 |  Barnton v Ashville  | Ray Parker Stadium | |
| Played at Ashville | |||
| 15:00 |  Runcorn Town v Stafford Town  | Viridor Community Stadium | |
| 15:00 |  Sandbach United v Cheadle Heath Nomads  | Sandbach Community Football Centre | |
| 15:00 |  Telford Town v Stockport Georgians  | DRM Aggregate Arena | |
| Saturday 15th November 2025 | Premier Division | ||
| 15:00 |  AFC Liverpool v Longridge Town  | Berry Street Garage Stadium | |
| 15:00 |  Burscough v Glossop North End  | The Community Ground | |
| 15:00 |  Chadderton v City of Liverpool  | Emplas Commercial North Stadium | |
| 15:00 |  Charnock Richard v Cheadle Town  | Mossie Park | |
| 15:00 |  Irlam v Abbey Hey  | The Silver St Stadium | |
| 15:00 |  Ramsbottom United v Pilkington  | Harry Williams Riverside Stadium | |
| 15:00 |  Stockport Town v Barnoldswick Town  | Stockport Sports Village | |
| 15:00 |  Wythenshawe v Euxton Villa  | Avensure Community Stadium | |
| 18:00 |  FC Isle of Man v West Didsbury & Chorlton  | The Bowl | |
| Saturday 15th November 2025 | First Division North | ||
| 15:00 |  Ashton Athletic v Garstang  | Brocstedes Park | |
| 15:00 |  Colne v Thornton Cleveleys  | Haffners Eats Stadium | |
| 15:00 |  Squires Gate v Steeton  | The Skiddle Community Stadium | |
| Saturday 15th November 2025 | First Division South | ||
| 15:00 |  Allscott Heath v Market Drayton Town  | The Giant Stadium | |
| 15:00 |  Foley Meir v Shawbury United  | Trentham Foods Stadium | |
| 15:00 |  Haughmond v Cammell Laird 1907  | Sundorne Sports Village | |
| Monday 17th November 2025 | Cheshire Senior Cup 2nd Rnd | ||
| 19:45 | Stockport Town v Warrington Town  | Stockport Sports Village | |
| Tuesday 18th November 2025 | Premier Division | ||
| 19:45 | Barnoldswick Town v Abbey Hey | Silentnight Stadium | |
| 19:45 | Cheadle Town v Litherland REMYCA  | The Ground Up Solutions Stadium | |
| 19:45 | City of Liverpool v Ramsbottom United | The Community Ground | |
| 19:45 | Glossop North End v FC St Helens | The Asgard Engineering Stadium | |
| Tuesday 18th November 2025 | First Division North | ||
| 20:00 |  Holker Old Boys v AFC Blackpool | The Handmark Engineering Stadium | |
| Tuesday 18th November 2025 | First Division South | ||
| 19:45 | Ashville v New Mills  | Ray Parker Stadium | |
| 19:45 | Sandbach United v Wolverhampton Casuals  | Sandbach Community Football Centre | |
| Tuesday 18th November 2025 | Cheshire Senior Cup 2nd Rnd | ||
| 19:45 | Runcorn Town v Stockport Georgians | Viridor Community Stadium | |
| Tuesday 18th November 2025 | Lancashire Challenge Trophy 2nd Rnd | ||
| 19:45 | Ashton Athletic v Lancaster City  | Brocstedes Park | |
| 19:45 |  Fulwood Amateurs v AFC Fylde  | Lightfoot Green Lane | |
| 19:45 | Longridge Town v Daisy Hill | Inglewhite Road | |
| 19:45 | Prestwich Heys v Padiham  | Adie Moran Park | |
| 19:45 | Squires Gate v Nelson | The Skiddle Community Stadium | |
| Tuesday 18th November 2025 | Liverpool Senior Cup Prelim Rnd | ||
| 19:45 |  MSB Woolton v Bootle  | Berry Street Garage Stadium | |
| Played at Bootle | |||
| Tuesday 18th November 2025 | Manchester Premier Cup Prelim Rnd | ||
| 19:45 |  Ashton United v Chadderton | Hurst Cross | |
| 19:45 |  Radcliffe v Irlam | Stainton Park | |
| Wednesday 19th November 2025 | The Macron Cup 3rd Rnd | ||
| 19:45 | Cammell Laird 1907 v AFC Liverpool | The OWS Engineering Ltd Stadium | |
| Wednesday 19th November 2025 | First Division North | ||
| 19:45 | Darwen FC v Bacup Borough | Multevo Group Anchor Ground | |
| Wednesday 19th November 2025 | Lancashire Challenge Trophy 2nd Rnd | ||
| 19:45 | West Didsbury & Chorlton v Clitheroe  | Step Places Stadium | |
| 20:00 | Garstang v Wythenshawe | The Riverside | |
| Friday 21st November 2025 | The Macron Cup 3rd Rnd | ||
| 19:45 | Euxton Villa v Charnock Richard | Jim Fowler Memorial Ground | |
| 19:45 | MSB Woolton v Thornton Cleveleys | Jericho Lane | |
| Saturday 22nd November 2025 | The Macron Cup 3rd Rnd | ||
| 15:00 | Burscough v AFC Blackpool | The Community Ground | |
| 15:00 | Cheadle Town v Chadderton | The Ground Up Solutions Stadium | |
| 15:00 | Ramsbottom United v West Didsbury & Chorlton | Harry Williams Riverside Stadium | |
| 15:00 | Sandbach United v Nelson | Sandbach Community Football Centre | |
| 15:00 | Telford Town v Runcorn Town | DRM Aggregate Arena | |
| Saturday 22nd November 2025 | Premier Division | ||
| 13:30 | Longridge Town v FC Isle of Man | Inglewhite Road | |
| 15:00 | Abbey Hey v Atherton LR | The Abbey Stadium | |
| 15:00 | Barnoldswick Town v FC St Helens | Silentnight Stadium | |
| 15:00 | City of Liverpool v Wythenshawe | The Community Ground | |
| 15:00 | Litherland REMYCA v Stockport Town | Litherland Sports Park | |
| 15:00 | Pilkington v Padiham | PSD Stadium | |
| 15:00 | Prestwich Heys v Glossop North End | Adie Moran Park | |
| 15:00 | South Liverpool v Irlam | Jericho Lane | |
| Saturday 22nd November 2025 | First Division North | ||
| 15:00 | Ashton Town v Fulwood Amateurs | The Bartons Group Stadium | |
| 15:00 | Bacup Borough v Squires Gate | Brian Boys West View Stadium | |
| 15:00 | Garstang v Colne | The Riverside | |
| 15:00 | Maghull v Darwen FC | DT Hughes Community Stadium | |
| 15:00 | Maine Road v Daisy Hill | Brantingham Road | |
| Saturday 22nd November 2025 | First Division South | ||
| 15:00 |  Alsager Town v Cheadle Heath Nomads | Wood Park | |
| 15:00 | Ashville v Shawbury United | Ray Parker Stadium | |
| 15:00 | Barnton v Eccleshall  | The Creative Hut Stadium | |
| 15:00 | New Mills v Foley Meir | Church Lane | |
| 15:00 |  Wolverhampton Sporting Community v Market Drayton Town | Pride Park | |
| Monday 24th November 2025 | Manchester Premier Cup 1st Rnd | ||
| 19:45 | Maine Road v Bury  | Brantingham Road | |
| Tuesday 25th November 2025 | Premier Division | ||
| 19:45 | Chadderton v Ramsbottom United | Emplas Commercial North Stadium | |
| 19:45 | Cheadle Town v Longridge Town | The Ground Up Solutions Stadium | |
| 19:45 | Wythenshawe v South Liverpool | Avensure Community Stadium | |
| Tuesday 25th November 2025 | First Division North | ||
| 19:45 | Ashton Athletic v AFC Blackpool | Brocstedes Park | |
| Tuesday 25th November 2025 | First Division South | ||
| 19:45 | Alsager Town v Barnton | Wood Park | |
| 19:45 | Runcorn Town v Allscott Heath | Viridor Community Stadium | |
| 20:00 | Stafford Town v Sandbach United | Evans Park | |
| Tuesday 25th November 2025 | Lancashire Challenge Trophy 2nd Rnd | ||
| 19:45 |  Bamber Bridge v Thornton Cleveleys | Sir Tom Finney Stadium | |
| Tuesday 25th November 2025 | Manchester Premier Cup 1st Rnd | ||
| 19:45 |  FC United of Manchester v Abbey Hey | Broadhurst Park | |
| 19:45 |  Wythenshawe Town v Glossop North End | Ericstan Park | |
| Wednesday 26th November 2025 | Premier Division | ||
| 19:45 | Litherland REMYCA v Prestwich Heys | Litherland Sports Park | |
| Wednesday 26th November 2025 | First Division North | ||
| 19:45 | MSB Woolton v Steeton | Jericho Lane | |
| 20:00 | Nelson v Garstang | The Daisy Arena Little Wembley | |
| Wednesday 26th November 2025 | First Division South | ||
| 19:45 | Telford Town v Wolverhampton Casuals | DRM Aggregate Arena | |
| Wednesday 26th November 2025 | Manchester Premier Cup 1st Rnd | ||
| 19:45 | West Didsbury & Chorlton v Stalybridge Celtic  | Step Places Stadium | |
| Friday 28th November 2025 | Premier Division | ||
| 19:45 | FC St Helens v Litherland REMYCA | SMS PRO SOCCER PARK | |
| Saturday 29th November 2025 | Premier Division | ||
| 14:00 | Prestwich Heys v FC Isle of Man | Adie Moran Park | |
| 15:00 | AFC Liverpool v Cheadle Town | Berry Street Garage Stadium | |
| 15:00 | Atherton LR v Abbey Hey | Crilly Park | |
| 15:00 | Barnoldswick Town v City of Liverpool | Silentnight Stadium | |
| 15:00 | Burscough v Padiham | The Community Ground | |
| 15:00 | Euxton Villa v Glossop North End | Jim Fowler Memorial Ground | |
| 15:00 | Ramsbottom United v Irlam | Harry Williams Riverside Stadium | |
| 15:00 | South Liverpool v Chadderton | Jericho Lane | |
| 15:00 | Stockport Town v Longridge Town | Stockport Sports Village | |
| 15:00 | West Didsbury & Chorlton v Charnock Richard | Step Places Stadium | |
| 15:00 | Wythenshawe v Pilkington | Avensure Community Stadium | |
| Saturday 29th November 2025 | First Division North | ||
| 15:00 | AFC Blackpool v Colne | Mechanics Ground | |
| 15:00 | Ashton Athletic v Steeton | Brocstedes Park | |
| 15:00 | Daisy Hill v Thornton Cleveleys | The Ginge Power Stadium | |
| 15:00 | Darwen FC v Ashton Town | Multevo Group Anchor Ground | |
| 15:00 |  Droylsden v Fulwood Amateurs | The Butchers Arms | |
| 15:00 | Garstang v Maine Road | The Riverside | |
| 15:00 | Holker Old Boys v Squires Gate | The Handmark Engineering Stadium | |
| 15:00 | Nelson v Maghull | The Daisy Arena Little Wembley | |
| Saturday 29th November 2025 | First Division South | ||
| 15:00 | Allscott Heath v New Mills | The Giant Stadium | |
| 15:00 | Cammell Laird 1907 v Wolverhampton Sporting Community | The OWS Engineering Ltd Stadium | |
| 15:00 | Eccleshall v Haughmond | Stoke Signage Stadium | |
| 15:00 | Foley Meir v Cheadle Heath Nomads | Trentham Foods Stadium | |
| 15:00 | Market Drayton Town v Barnton | Greenfields Sports Ground | |
| 15:00 | Sandbach United v Stockport Georgians | Sandbach Community Football Centre | |
| 15:00 | Shawbury United v Telford Town | Shawbury Utd Community Sports and Recreational Centre | |
| 15:00 | Stafford Town v Alsager Town | Evans Park | |
| 15:00 | Wolverhampton Casuals v Runcorn Town | Brinsford Stadium | |
| Monday 1st December 2025 | First Division North | ||
| 19:45 | Daisy Hill v AFC Blackpool | The Ginge Power Stadium | |
| Tuesday 2nd December 2025 | Premier Division | ||
| 19:45 | Abbey Hey v Burscough | The Abbey Stadium | |
| 19:45 | Barnoldswick Town v Longridge Town | Silentnight Stadium | |
| 19:45 | Charnock Richard v Atherton LR | Mossie Park | |
| 19:45 | Irlam v Chadderton | The Silver St Stadium | |
| 19:45 | Wythenshawe v Ramsbottom United | Avensure Community Stadium | |
| Tuesday 2nd December 2025 | First Division North | ||
| 19:45 | Ashton Athletic v Fulwood Amateurs | Brocstedes Park | |
| 19:45 | Droylsden v Nelson | The Butchers Arms | |
| Tuesday 2nd December 2025 | First Division South | ||
| 19:45 | Stockport Georgians v Telford Town | Cromley Road | |
| 20:00 | Wolverhampton Sporting Community v Runcorn Town | Pride Park | |
| Tuesday 2nd December 2025 | Derbyshire Senior Cup 3rd Rnd | ||
| 19:45 | Glossop North End v Matlock Town  | The Asgard Engineering Stadium | |
| Tuesday 2nd December 2025 | Staffordshire Senior Cup 2nd Rnd | ||
| 19:45 | Foley Meir v Wolverhampton Casuals | Trentham Foods Stadium | |
| 20:00 | Stafford Town v Hanley Town  | Evans Park | |
| Wednesday 3rd December 2025 | Premier Division | ||
| 19:45 | Litherland REMYCA v Cheadle Town | Litherland Sports Park | |
| 19:45 | West Didsbury & Chorlton v Stockport Town | Step Places Stadium | |
| Friday 14th November 2025 Premier Division |
| Atherton LR v Prestwich Heys (19:45) |
| FC St Helens v South Liverpool (19:45) |
| Saturday 15th November 2025 The Edward Case Cup 2nd Round North |
| Ashton Town v Darwen FC (15:00) |
| Daisy Hill v Nelson (15:00) |
| Daisy Hill v Nelson (15:00) |
| Maghull v Bacup Borough (15:00) |
| Maine Road v AFC Blackpool (15:00) |
| Saturday 15th November 2025 The Edward Case Cup 2nd Round South |
|
| Barnton v Ashville (15:00) | |
| Played at Ashville | |
| Runcorn Town v Stafford Town (15:00) | |
| Sandbach United v Cheadle Heath Nomads (15:00) | |
| Telford Town v Stockport Georgians (15:00) | |
| Saturday 15th November 2025 Premier Division |
| AFC Liverpool v Longridge Town (15:00) |
| Burscough v Glossop North End (15:00) |
| Chadderton v City of Liverpool (15:00) |
| Charnock Richard v Cheadle Town (15:00) |
| Irlam v Abbey Hey (15:00) |
| Ramsbottom United v Pilkington (15:00) |
| Stockport Town v Barnoldswick Town (15:00) |
| Wythenshawe v Euxton Villa (15:00) |
| FC Isle of Man v West Didsbury & Chorlton (18:00) |
| Saturday 15th November 2025 First Division North |
| Ashton Athletic v Garstang (15:00) |
| Colne v Thornton Cleveleys (15:00) |
| Squires Gate v Steeton (15:00) |
| Saturday 15th November 2025 First Division South |
| Allscott Heath v Market Drayton Town (15:00) |
| Foley Meir v Shawbury United (15:00) |
| Haughmond v Cammell Laird 1907 (15:00) |
| Monday 17th November 2025 Cheshire Senior Cup 2nd Round |
| Stockport Town v Warrington Town (19:45) |
| Tuesday 18th November 2025 Premier Division |
| Barnoldswick Town v Abbey Hey (19:45) |
| Cheadle Town v Litherland REMYCA (19:45) |
| City of Liverpool v Ramsbottom United (19:45) |
| Glossop North End v FC St Helens (19:45) |
| Tuesday 18th November 2025 First Division North |
| Holker Old Boys v AFC Blackpool (20:00) |
| Tuesday 18th November 2025 First Division South |
| Ashville v New Mills (19:45) |
| Sandbach United v Wolverhampton Casuals (19:45) |
| Tuesday 18th November 2025 Cheshire Senior Cup 2nd Round |
| Runcorn Town v Stockport Georgians (19:45) |
| Tuesday 18th November 2025 Lancashire Challenge Trophy 2nd Round |
| Ashton Athletic v Lancaster City (19:45) |
| Fulwood Amateurs v AFC Fylde (19:45) |
| Longridge Town v Daisy Hill (19:45) |
| Prestwich Heys v Padiham (19:45) |
| Squires Gate v Nelson (19:45) |
| Tuesday 18th November 2025 Liverpool Senior Cup Preliminary Round |
|
| MSB Woolton v Bootle (19:45) | |
| Played at Bootle | |
| Tuesday 18th November 2025 Manchester Premier Cup Preliminary Round |
| Ashton United v Chadderton (19:45) |
| Radcliffe v Irlam (19:45) |
| Wednesday 19th November 2025 The Macron Cup 3rd Round |
| Cammell Laird 1907 v AFC Liverpool (19:45) |
| Wednesday 19th November 2025 First Division North |
| Darwen FC v Bacup Borough (19:45) |
| Wednesday 19th November 2025 Lancashire Challenge Trophy 2nd Round |
| West Didsbury & Chorlton v Clitheroe (19:45) |
| Garstang v Wythenshawe (20:00) |
| Friday 21st November 2025 The Macron Cup 3rd Round |
| Euxton Villa v Charnock Richard (19:45) |
| MSB Woolton v Thornton Cleveleys (19:45) |
| Saturday 22nd November 2025 The Macron Cup 3rd Round |
| Burscough v AFC Blackpool (15:00) |
| Cheadle Town v Chadderton (15:00) |
| Ramsbottom United v West Didsbury & Chorlton (15:00) |
| Sandbach United v Nelson (15:00) |
| Telford Town v Runcorn Town (15:00) |
| Saturday 22nd November 2025 Premier Division |
| Longridge Town v FC Isle of Man (13:30) |
| Abbey Hey v Atherton LR (15:00) |
| Barnoldswick Town v FC St Helens (15:00) |
| City of Liverpool v Wythenshawe (15:00) |
| Litherland REMYCA v Stockport Town (15:00) |
| Pilkington v Padiham (15:00) |
| Prestwich Heys v Glossop North End (15:00) |
| South Liverpool v Irlam (15:00) |
| Saturday 22nd November 2025 First Division North |
| Ashton Town v Fulwood Amateurs (15:00) |
| Bacup Borough v Squires Gate (15:00) |
| Garstang v Colne (15:00) |
| Maghull v Darwen FC (15:00) |
| Maine Road v Daisy Hill (15:00) |
| Saturday 22nd November 2025 First Division South |
| Alsager Town v Cheadle Heath Nomads (15:00) |
| Ashville v Shawbury United (15:00) |
| Barnton v Eccleshall (15:00) |
| New Mills v Foley Meir (15:00) |
| Wolverhampton Sporting Community v Market Drayton Town (15:00) |
| Monday 24th November 2025 Manchester Premier Cup 1st Round |
| Maine Road v Bury (19:45) |
| Tuesday 25th November 2025 Premier Division |
| Chadderton v Ramsbottom United (19:45) |
| Cheadle Town v Longridge Town (19:45) |
| Wythenshawe v South Liverpool (19:45) |
| Tuesday 25th November 2025 First Division North |
| Ashton Athletic v AFC Blackpool (19:45) |
| Tuesday 25th November 2025 First Division South |
| Alsager Town v Barnton (19:45) |
| Runcorn Town v Allscott Heath (19:45) |
| Stafford Town v Sandbach United (20:00) |
| Tuesday 25th November 2025 Lancashire Challenge Trophy 2nd Round |
| Bamber Bridge v Thornton Cleveleys (19:45) |
| Tuesday 25th November 2025 Manchester Premier Cup 1st Round |
| FC United of Manchester v Abbey Hey (19:45) |
| Wythenshawe Town v Glossop North End (19:45) |
| Wednesday 26th November 2025 Premier Division |
| Litherland REMYCA v Prestwich Heys (19:45) |
| Wednesday 26th November 2025 First Division North |
| MSB Woolton v Steeton (19:45) |
| Nelson v Garstang (20:00) |
| Wednesday 26th November 2025 First Division South |
| Telford Town v Wolverhampton Casuals (19:45) |
| Wednesday 26th November 2025 Manchester Premier Cup 1st Round |
| West Didsbury & Chorlton v Stalybridge Celtic (19:45) |
| Friday 28th November 2025 Premier Division |
| FC St Helens v Litherland REMYCA (19:45) |
| Saturday 29th November 2025 Premier Division |
| Prestwich Heys v FC Isle of Man (14:00) |
| AFC Liverpool v Cheadle Town (15:00) |
| Atherton LR v Abbey Hey (15:00) |
| Barnoldswick Town v City of Liverpool (15:00) |
| Burscough v Padiham (15:00) |
| Euxton Villa v Glossop North End (15:00) |
| Ramsbottom United v Irlam (15:00) |
| South Liverpool v Chadderton (15:00) |
| Stockport Town v Longridge Town (15:00) |
| West Didsbury & Chorlton v Charnock Richard (15:00) |
| Wythenshawe v Pilkington (15:00) |
| Saturday 29th November 2025 First Division North |
| AFC Blackpool v Colne (15:00) |
| Ashton Athletic v Steeton (15:00) |
| Daisy Hill v Thornton Cleveleys (15:00) |
| Darwen FC v Ashton Town (15:00) |
| Droylsden v Fulwood Amateurs (15:00) |
| Garstang v Maine Road (15:00) |
| Holker Old Boys v Squires Gate (15:00) |
| Nelson v Maghull (15:00) |
| Saturday 29th November 2025 First Division South |
| Allscott Heath v New Mills (15:00) |
| Cammell Laird 1907 v Wolverhampton Sporting Community (15:00) |
| Eccleshall v Haughmond (15:00) |
| Foley Meir v Cheadle Heath Nomads (15:00) |
| Market Drayton Town v Barnton (15:00) |
| Sandbach United v Stockport Georgians (15:00) |
| Shawbury United v Telford Town (15:00) |
| Stafford Town v Alsager Town (15:00) |
| Wolverhampton Casuals v Runcorn Town (15:00) |
| Monday 1st December 2025 First Division North |
| Daisy Hill v AFC Blackpool (19:45) |
| Tuesday 2nd December 2025 Premier Division |
| Abbey Hey v Burscough (19:45) |
| Barnoldswick Town v Longridge Town (19:45) |
| Charnock Richard v Atherton LR (19:45) |
| Irlam v Chadderton (19:45) |
| Wythenshawe v Ramsbottom United (19:45) |
| Tuesday 2nd December 2025 First Division North |
| Ashton Athletic v Fulwood Amateurs (19:45) |
| Droylsden v Nelson (19:45) |
| Tuesday 2nd December 2025 First Division South |
| Stockport Georgians v Telford Town (19:45) |
| Wolverhampton Sporting Community v Runcorn Town (20:00) |
| Tuesday 2nd December 2025 Derbyshire Senior Cup 3rd Round |
| Glossop North End v Matlock Town (19:45) |
| Tuesday 2nd December 2025 Staffordshire Senior Cup 2nd Round |
| Foley Meir v Wolverhampton Casuals (19:45) |
| Stafford Town v Hanley Town (20:00) |
| Wednesday 3rd December 2025 Premier Division |
| Litherland REMYCA v Cheadle Town (19:45) |
| West Didsbury & Chorlton v Stockport Town (19:45) |
