| Saturday 23rd October 2021 | The Buildbase FA Vase 1st Rnd | ||
| 15:00 |  Abbey Hey v Parkgate  |
The Abbey Stadium | |
| 15:00 |  Barton Town v Cleator Moor Celtic  |
The Easy Buy Stadium | |
| 15:00 |  Billingham Synthonia v FC Isle of Man  |
The Motif8 Stadium | |
| 15:00 |  Burscough v Garforth Town  |
The Community Ground | |
| 15:00 |  Consett v Atherton LR  |
Belle Vue Park | |
| 15:00 |  Emley AFC v Longridge Town  |
Fantastic Media Welfare Ground | |
| 15:00 |  Eynesbury Rovers v Sandbach United  |
Alfred Hall Memorial Ground | |
| 15:00 |  Holker Old Boys v Skelmersdale United  |
The Handmark Engineering Stadium | |
| 15:00 |  Newcastle Benfield v Golcar United  |
Sam Smiths Park | |
| 15:00 |  Pilkington v West Allotment Celtic  |
The Arcoframe Stadium | |
| 15:00 |  Prestwich Heys v Penrith  |
Adie Moran Park | |
| 15:00 |  Seaham Red Star v Wythenshawe Town  |
Seaham Town Park | |
| 15:00 |  Sunderland Ryhope CW v Bury AFC  |
||
| 15:00 |  Thornaby v South Liverpool  |
Teesdale Park | |
| 15:00 |  Vauxhall Motors v North Shields  |
The vanEupen Arena | |
| Saturday 23rd October 2021 | Premier Division | ||
| 15:00 |  Charnock Richard v Congleton Town  |
Mossie Park | |
| 15:00 |  Irlam v Lower Breck  |
The RG3 Digital Stadium | |
| 15:00 |  Litherland REMYCA v Avro  |
Litherland Sports Park | |
| 15:00 |  Macclesfield v Padiham  |
The Leasing.com Stadium | |
| 15:00 |  Runcorn Town v Winsford United  |
Viridor Community Stadium | |
| Saturday 23rd October 2021 | First Division North | ||
| 15:00 |  Chadderton v Steeton  |
The Falcon Fire Stadium | |
| 15:00 |  Garstang v Ashton Town  |
The Riverside | |
| 15:00 |  Nelson v AFC Darwen  |
Little Wembley | |
| Saturday 23rd October 2021 | First Division South | ||
| 15:00 |  Brocton v Cheadle Town  |
Silkmore Lane Sports Ground | |
| 15:00 |  Cheadle Heath Nomads v St Martins  |
ProSeal Stadium | |
| 15:00 |  Eccleshall v Abbey Hulton United  |
Pershall Park | |
| 15:00 |  Ellesmere Rangers v Alsager Town  |
Beech Grove Stadium | |
| 15:00 |  Maine Road v Cammell Laird 1907  |
Brantingham Road | |
| 15:00 |  New Mills v Stafford Town  |
Church Lane | |
| 15:00 |  Rocester v West Didsbury & Chorlton  |
Hillsfield | |
| 15:00 |  Stockport Town v Barnton  |
Stockport Sports Village | |
| Sunday 24th October 2021 | The Buildbase FA Vase 1st Rnd | ||
| 14:00 |  AFC Liverpool v Newton Aycliffe  |
The Marine Travel Arena | |
| Tuesday 26th October 2021 | Premier Division | ||
| 19:45 | Charnock Richard v Squires Gate  |
Mossie Park | |
| 19:45 | Longridge Town v Runcorn Town |
The Mike Riding Ground | |
| 19:45 | Prestwich Heys v AFC Liverpool |
Adie Moran Park | |
| 19:45 | Wythenshawe Town v Barnoldswick Town  |
Ericstan Park | |
| 20:00 | Skelmersdale United v Winsford United |
One Call Stadium at JMO Sports Park | |
| Tuesday 26th October 2021 | First Division North | ||
| 19:45 | Atherton LR v Nelson |
Crilly Park | |
| 19:45 | Golcar United v South Liverpool |
Skye Direct Stadium | |
| 19:45 | Holker Old Boys v Daisy Hill  |
The Handmark Engineering Stadium | |
| Tuesday 26th October 2021 | First Division South | ||
| 19:45 |  Wythenshawe Amateurs v Abbey Hey |
Hollyhedge Park | |
| Tuesday 26th October 2021 | Cheshire Senior Cup 1st Rnd | ||
| 19:45 | Congleton Town v Stalybridge Celtic  |
Cheshire Silk 106.9 Stadium | |
| 19:45 |  Crewe Alexandra v Sandbach United |
Gresty Road | |
| Wednesday 27th October 2021 | First Division North | ||
| 19:45 | Garstang v Cleator Moor Celtic |
The Riverside | |
| 19:45 | Pilkington v Bury AFC |
The Arcoframe Stadium | |
| Wednesday 27th October 2021 | First Division South | ||
| 19:45 | Cheadle Town v FC Isle of Man |
Park Road Stadium | |
| Wednesday 27th October 2021 | Cheshire Senior Cup 1st Rnd | ||
| 19:45 |  Northwich Victoria v Tranmere Rovers  |
Wincham Park | |
| Friday 29th October 2021 | Premier Division | ||
| 20:00 | AFC Liverpool v Wythenshawe Town |
The Marine Travel Arena | |
| 20:00 | Lower Breck v Macclesfield |
Anfield Sports Community Centre | |
| Saturday 30th October 2021 | Premier Division | ||
| 15:00 |  Ashton Athletic v Irlam |
Brocstedes Park | |
| 15:00 | Avro v Runcorn Town |
Vestacare Stadium | |
| 15:00 | Barnoldswick Town v Skelmersdale United |
Silentnight Stadium | |
| 15:00 | Congleton Town v Winsford United |
Cheshire Silk 106.9 Stadium | |
| 15:00 | Litherland REMYCA v Padiham |
Litherland Sports Park | |
| 15:00 | Prestwich Heys v Longridge Town |
Adie Moran Park | |
| 15:00 | Squires Gate v Northwich Victoria |
The Brian Addison Stadium | |
| 15:00 | Vauxhall Motors v Burscough |
The vanEupen Arena | |
| Saturday 30th October 2021 | First Division North | ||
| 15:00 | AFC Darwen v AFC Blackpool  |
WEC Group Anchor Ground | |
| 15:00 | Ashton Town v Campion  |
Profiles Park | |
| 15:00 | Bury AFC P-P Chadderton |
Neuven Stadium | |
| Postponed due to Radcliffe in FA Trophy | |||
| 15:00 | Cleator Moor Celtic v Atherton LR |
Inglenorth Park | |
| 15:00 | Daisy Hill v Ilkley Town  |
New Sirs | |
| 15:00 | Golcar United v St Helens Town  |
Skye Direct Stadium | |
| 15:00 | Nelson v Bacup Borough  |
Little Wembley | |
| 15:00 | Pilkington v Garstang |
The Arcoframe Stadium | |
| 15:00 | Steeton v Holker Old Boys |
Marley Stadium | |
| Saturday 30th October 2021 | First Division South | ||
| 15:00 | Alsager Town v Eccleshall |
Woodpark Stadium | |
| 15:00 | Barnton v St Martins |
Townfield | |
| 15:00 | Cammell Laird 1907 v Stockport Town |
Prabhu Ventures Ltd Arena | |
| 15:00 | Cheadle Town v Sandbach United |
Park Road Stadium | |
| 15:00 | Ellesmere Rangers v Abbey Hulton United |
Beech Grove Stadium | |
| 15:00 | FC Isle of Man v Brocton |
The Bowl | |
| 15:00 | Maine Road v Cheadle Heath Nomads |
Brantingham Road | |
| 15:00 | Rocester v New Mills |
Hillsfield | |
| 15:00 | Stafford Town v Abbey Hey |
Evans Park | |
| 15:00 | West Didsbury & Chorlton v Wythenshawe Amateurs |
Step Places Stadium | |
| Tuesday 2nd November 2021 | Premier Division | ||
| 19:45 | Burscough v Northwich Victoria |
The Community Ground | |
| Tuesday 2nd November 2021 | First Division North | ||
| 19:45 | Bury AFC v Chadderton |
Neuven Stadium | |
| 20:00 | Ilkley Town v Atherton LR |
MPM Stadium | |
| Tuesday 2nd November 2021 | First Division South | ||
| 20:00 | St Martins v FC Isle of Man |
Park Hall Stadium | |
| Tuesday 2nd November 2021 | Cheshire Senior Cup 1st Rnd | ||
| 19:45 | Macclesfield v Cheadle Heath Nomads |
The Leasing.com Stadium | |
| Tuesday 2nd November 2021 | West Riding County Cup 1st Rnd | ||
| 19:45 | Golcar United v Steeton |
Skye Direct Stadium | |
| Wednesday 3rd November 2021 | First Division North | ||
| 19:45 | AFC Darwen v Cleator Moor Celtic |
WEC Group Anchor Ground | |
| Saturday 6th November 2021 | Premier Division | ||
| 15:00 | AFC Liverpool v Barnoldswick Town |
The Marine Travel Arena | |
| 15:00 | Burscough v Prestwich Heys |
The Community Ground | |
| 15:00 | Congleton Town v Lower Breck |
Cheshire Silk 106.9 Stadium | |
| 15:00 | Irlam v Charnock Richard |
The RG3 Digital Stadium | |
| 15:00 | Longridge Town v Litherland REMYCA |
The Mike Riding Ground | |
| 15:00 | Macclesfield v Runcorn Town |
The Leasing.com Stadium | |
| 15:00 | Northwich Victoria v Ashton Athletic |
Wincham Park | |
| 15:00 | Padiham v Skelmersdale United |
Ruby Civil Arena | |
| 15:00 | Winsford United v Squires Gate |
Barton Stadium | |
| 15:00 | Wythenshawe Town v Avro |
Ericstan Park | |
| Saturday 6th November 2021 | First Division North | ||
| 15:00 | AFC Blackpool v Golcar United |
Mechanics Ground | |
| 15:00 | Bacup Borough v Atherton LR |
Brian Boys West View Stadium | |
| 15:00 | Campion v Pilkington |
The Players Cars Stadium | |
| 15:00 | Chadderton v Cleator Moor Celtic |
The Falcon Fire Stadium | |
| 15:00 | Daisy Hill v Steeton |
New Sirs | |
| 15:00 | Holker Old Boys v Bury AFC |
The Handmark Engineering Stadium | |
| 15:00 | Nelson v Ashton Town |
Little Wembley | |
| 15:00 | South Liverpool v Garstang |
Jericho Lane | |
| 15:00 | St Helens Town v AFC Darwen |
Arcoframe Stadium | |
| Saturday 6th November 2021 | First Division South | ||
| 15:00 | Abbey Hey v Rocester |
The Abbey Stadium | |
| 15:00 | Alsager Town v Abbey Hulton United |
Woodpark Stadium | |
| 15:00 | Brocton v Maine Road |
Silkmore Lane Sports Ground | |
| 15:00 | Cammell Laird 1907 v New Mills |
Prabhu Ventures Ltd Arena | |
| 15:00 | Cheadle Town v Ellesmere Rangers |
Park Road Stadium | |
| 15:00 | FC Isle of Man v Stafford Town |
The Bowl | |
| 15:00 | Sandbach United v Barnton |
Sandbach Community Football Centre | |
| 15:00 | Stockport Town v St Martins |
Stockport Sports Village | |
| 15:00 | West Didsbury & Chorlton v Eccleshall |
Step Places Stadium | |
| 15:00 | Wythenshawe Amateurs v Cheadle Heath Nomads |
Hollyhedge Park | |
| Tuesday 9th November 2021 | Premier Division | ||
| 19:45 | AFC Liverpool v Macclesfield |
The Marine Travel Arena | |
| 19:45 | Burscough v Avro |
The Community Ground | |
| 19:45 | Congleton Town v Skelmersdale United |
Cheshire Silk 106.9 Stadium | |
| 19:45 | Prestwich Heys v Runcorn Town |
Adie Moran Park | |
| 19:45 | Wythenshawe Town v Charnock Richard |
Ericstan Park | |
| Tuesday 9th November 2021 | First Division North | ||
| 19:45 | Ashton Town v Daisy Hill |
Profiles Park | |
| 19:45 | Bury AFC v AFC Blackpool |
Neuven Stadium | |
| 19:45 | Cleator Moor Celtic v Pilkington |
Inglenorth Park | |
| 19:45 | Golcar United v AFC Darwen |
Skye Direct Stadium | |
| 20:00 | Bacup Borough v South Liverpool |
Brian Boys West View Stadium | |
| Tuesday 9th November 2021 | First Division South | ||
| 19:45 | Alsager Town v New Mills |
Woodpark Stadium | |
| 19:45 | Cammell Laird 1907 v Abbey Hey |
Prabhu Ventures Ltd Arena | |
| 19:45 | Ellesmere Rangers v Rocester |
Beech Grove Stadium | |
| 19:45 | Sandbach United v FC Isle of Man |
Sandbach Community Football Centre | |
| 19:45 | West Didsbury & Chorlton v Cheadle Town |
Step Places Stadium | |
| Wednesday 10th November 2021 | Premier Division | ||
| 19:45 | Barnoldswick Town v Northwich Victoria |
Silentnight Stadium | |
| 19:45 | Litherland REMYCA v Winsford United |
Litherland Sports Park | |
| Wednesday 10th November 2021 | First Division North | ||
| 20:00 | Garstang v Chadderton |
The Riverside | |
| Wednesday 10th November 2021 | First Division South | ||
| 19:45 | Barnton v Maine Road |
Townfield | |
| Wednesday 10th November 2021 | Staffordshire Senior Cup 1st Rnd | ||
| 19:45 | Abbey Hulton United v Stoke City  |
Drayton Beaumont Park | |
| Thursday 11th November 2021 | Premier Division | ||
| 20:00 | Lower Breck v Padiham |
Anfield Sports Community Centre | |
| Thursday 11th November 2021 | First Division North | ||
| 19:45 | St Helens Town v Holker Old Boys |
Arcoframe Stadium | |
| Saturday 23rd October 2021 The Buildbase FA Vase 1st Rnd |
| Abbey Hey v Parkgate (15:00) |
| Barton Town v Cleator Moor (15:00) |
| Billingham Syn v FC Isle of Man (15:00) |
| Burscough v Garforth Town (15:00) |
| Consett v Atherton LR (15:00) |
| Emley AFC v Longridge Town (15:00) |
| Eynesbury Rovers v Sandbach United (15:00) |
| Holker OB v Skelmersdale Utd (15:00) |
| Newcstle Benfld v Golcar United (15:00) |
| Pilkington v West Allotment (15:00) |
| Prestwich Heys v Penrith (15:00) |
| Seaham RS v Wythenshawe Town (15:00) |
| Sunderland RCW v Bury AFC (15:00) |
| Thornaby v South Liverpool (15:00) |
| Vauxhall Mtrs v North Shields (15:00) |
| Saturday 23rd October 2021 Premier Division |
| Charnock Richard v Congleton Town (15:00) |
| Irlam v Lower Breck (15:00) |
| Litherland REMY v Avro (15:00) |
| Macclesfield v Padiham (15:00) |
| Runcorn Town v Winsford United (15:00) |
| Saturday 23rd October 2021 First Division North |
| Chadderton v Steeton (15:00) |
| Garstang v Ashton Town (15:00) |
| Nelson v AFC Darwen (15:00) |
| Saturday 23rd October 2021 First Division South |
| Brocton v Cheadle Town (15:00) |
| Cheadle Heath v St Martins (15:00) |
| Eccleshall v Abbey Hulton Utd (15:00) |
| Ellesmere Rngrs v Alsager Town (15:00) |
| Maine Road v Cammell Laird (15:00) |
| New Mills v Stafford Town (15:00) |
| Rocester v West Didsbury (15:00) |
| Stockport Town v Barnton (15:00) |
| Sunday 24th October 2021 The Buildbase FA Vase 1st Rnd |
| AFC Liverpool v Newton Aycliffe (14:00) |
| Tuesday 26th October 2021 Premier Division |
| Charnock Richard v Squires Gate (19:45) |
| Longridge Town v Runcorn Town (19:45) |
| Prestwich Heys v AFC Liverpool (19:45) |
| Wythenshawe Town v Barnoldswick Town (19:45) |
| Skelmersdale Utd v Winsford United (20:00) |
| Tuesday 26th October 2021 First Division North |
| Atherton LR v Nelson (19:45) |
| Golcar United v South Liverpool (19:45) |
| Holker OB v Daisy Hill (19:45) |
| Tuesday 26th October 2021 First Division South |
| Wythenshawe Am v Abbey Hey (19:45) |
| Tuesday 26th October 2021 Cheshire Senior Cup 1st Rnd |
| Congleton Town v Stalybridge Cel (19:45) |
| Crewe Alexandra v Sandbach United (19:45) |
| Wednesday 27th October 2021 First Division North |
| Garstang v Cleator Moor (19:45) |
| Pilkington v Bury AFC (19:45) |
| Wednesday 27th October 2021 First Division South |
| Cheadle Town v FC Isle of Man (19:45) |
| Wednesday 27th October 2021 Cheshire Senior Cup 1st Rnd |
| Northwich Vics v Tranmere Rovers (19:45) |
| Friday 29th October 2021 Premier Division |
| AFC Liverpool v Wythenshawe Town (20:00) |
| Lower Breck v Macclesfield (20:00) |
| Saturday 30th October 2021 Premier Division |
| Ashton Athletic v Irlam (15:00) |
| Avro v Runcorn Town (15:00) |
| Barnoldswick Town v Skelmersdale Utd (15:00) |
| Congleton Town v Winsford United (15:00) |
| Litherland REMY v Padiham (15:00) |
| Prestwich Heys v Longridge Town (15:00) |
| Squires Gate v Northwich Vics (15:00) |
| Vauxhall Mtrs v Burscough (15:00) |
| Saturday 30th October 2021 First Division North |
|
| AFC Darwen v AFC Blackpool (15:00) | |
| Ashton Town v Campion (15:00) | |
| Bury AFC P-P Chadderton (15:00) | |
| Postponed due to Radcliffe in FA Trophy | |
| Cleator Moor v Atherton LR (15:00) | |
| Daisy Hill v Ilkley Town (15:00) | |
| Golcar United v St Helens Town (15:00) | |
| Nelson v Bacup Borough (15:00) | |
| Pilkington v Garstang (15:00) | |
| Steeton v Holker OB (15:00) | |
| Saturday 30th October 2021 First Division South |
| Alsager Town v Eccleshall (15:00) |
| Barnton v St Martins (15:00) |
| Cammell Laird v Stockport Town (15:00) |
| Cheadle Town v Sandbach United (15:00) |
| Ellesmere Rngrs v Abbey Hulton Utd (15:00) |
| FC Isle of Man v Brocton (15:00) |
| Maine Road v Cheadle Heath (15:00) |
| Rocester v New Mills (15:00) |
| Stafford Town v Abbey Hey (15:00) |
| West Didsbury v Wythenshawe Am (15:00) |
| Tuesday 2nd November 2021 Premier Division |
| Burscough v Northwich Vics (19:45) |
| Tuesday 2nd November 2021 First Division North |
| Bury AFC v Chadderton (19:45) |
| Ilkley Town v Atherton LR (20:00) |
| Tuesday 2nd November 2021 First Division South |
| St Martins v FC Isle of Man (20:00) |
| Tuesday 2nd November 2021 Cheshire Senior Cup 1st Rnd |
| Macclesfield v Cheadle Heath (19:45) |
| Tuesday 2nd November 2021 West Riding County Cup 1st Rnd |
| Golcar United v Steeton (19:45) |
| Wednesday 3rd November 2021 First Division North |
| AFC Darwen v Cleator Moor (19:45) |
| Saturday 6th November 2021 Premier Division |
| AFC Liverpool v Barnoldswick Town (15:00) |
| Burscough v Prestwich Heys (15:00) |
| Congleton Town v Lower Breck (15:00) |
| Irlam v Charnock Richard (15:00) |
| Longridge Town v Litherland REMY (15:00) |
| Macclesfield v Runcorn Town (15:00) |
| Northwich Vics v Ashton Athletic (15:00) |
| Padiham v Skelmersdale Utd (15:00) |
| Winsford United v Squires Gate (15:00) |
| Wythenshawe Town v Avro (15:00) |
| Saturday 6th November 2021 First Division North |
| AFC Blackpool v Golcar United (15:00) |
| Bacup Borough v Atherton LR (15:00) |
| Campion v Pilkington (15:00) |
| Chadderton v Cleator Moor (15:00) |
| Daisy Hill v Steeton (15:00) |
| Holker OB v Bury AFC (15:00) |
| Nelson v Ashton Town (15:00) |
| South Liverpool v Garstang (15:00) |
| St Helens Town v AFC Darwen (15:00) |
| Saturday 6th November 2021 First Division South |
| Abbey Hey v Rocester (15:00) |
| Alsager Town v Abbey Hulton Utd (15:00) |
| Brocton v Maine Road (15:00) |
| Cammell Laird v New Mills (15:00) |
| Cheadle Town v Ellesmere Rngrs (15:00) |
| FC Isle of Man v Stafford Town (15:00) |
| Sandbach United v Barnton (15:00) |
| Stockport Town v St Martins (15:00) |
| West Didsbury v Eccleshall (15:00) |
| Wythenshawe Am v Cheadle Heath (15:00) |
| Tuesday 9th November 2021 Premier Division |
| AFC Liverpool v Macclesfield (19:45) |
| Burscough v Avro (19:45) |
| Congleton Town v Skelmersdale Utd (19:45) |
| Prestwich Heys v Runcorn Town (19:45) |
| Wythenshawe Town v Charnock Richard (19:45) |
| Tuesday 9th November 2021 First Division North |
| Ashton Town v Daisy Hill (19:45) |
| Bury AFC v AFC Blackpool (19:45) |
| Cleator Moor v Pilkington (19:45) |
| Golcar United v AFC Darwen (19:45) |
| Bacup Borough v South Liverpool (20:00) |
| Tuesday 9th November 2021 First Division South |
| Alsager Town v New Mills (19:45) |
| Cammell Laird v Abbey Hey (19:45) |
| Ellesmere Rngrs v Rocester (19:45) |
| Sandbach United v FC Isle of Man (19:45) |
| West Didsbury v Cheadle Town (19:45) |
| Wednesday 10th November 2021 Premier Division |
| Barnoldswick Town v Northwich Vics (19:45) |
| Litherland REMY v Winsford United (19:45) |
| Wednesday 10th November 2021 First Division North |
| Garstang v Chadderton (20:00) |
| Wednesday 10th November 2021 First Division South |
| Barnton v Maine Road (19:45) |
| Wednesday 10th November 2021 Staffordshire Senior Cup 1st Rnd |
| Abbey Hulton Utd v Stoke City (19:45) |
| Thursday 11th November 2021 Premier Division |
| Lower Breck v Padiham (20:00) |
| Thursday 11th November 2021 First Division North |
| St Helens Town v Holker OB (19:45) |
