Premier Division games set for Saturday include Litherland REMYCA looking to bounce back from two straight defeats away at Padiham who exited the FA Cup at the hands of Marine in a midweek replay.
Another NWCFL side who departed the FA Cup after a midweek replay are Winsford United - on the wrong side of a 3-1 result v Ramsbottom United - and they host top of the division Rylands whose last defeat came at the hands of Runcorn Town back on August 10th.
Bootle have recorded back-to-back wins after a slow start and up next is a trip to Squires Gate who advanced in the FA Vase last time out but needed extra time to do so.
Hanley Town also needed extra time to progress in that competition, beating Eccleshall 3-2, but return to league action when they travel to an Ashton Athletic team who broke a four-game losing streak when they beat AFC Darwen in their last game.
FIRST DIVISION NORTH
A chance for Ashton Town to claim the lead in the division if they beat Nelson - losers to Seaham Red Star in the FA Vase on Saturday.
Emley AFC defeated Burscough in an FA Vase replay on Wednesday, and they face a similar journey when they go to Pilkington on Saturday, with Pilks currently second bottom in the league table.
Garstang's new manager Richard Cookney faces his first league game and will be looking to move up the table when they travel to a Chadderton side that have won two of their last six.
Daisy Hill are currently just outside the top four in the table and they host Golcar United on Saturday who haven't been in action since their 4-1 victory over Emley.
Atherton LR and St Helens Town both went out of the FA Vase at the first hurdle in their last games and will be seeking revival when they clash in the league this weekend.
FIRST DIVISION SOUTH
With the top three not in league action this weekend, Stone Old Alleynians have the chance to go top of the league if they can defeat a Cammell Laird team who have lost three of their last six games.
After winning their opening three games, St Martins have since lost their next five, with a trip to Wythenshawe Town set for Saturday. Town have won their last two games 5-2 and 7-0.
Sandbach United won their FA Vase game 13-0 (that's not a typo) but now they return to league action when they go to Cheadle Heath Nomads fresh off a 5-3 win against Ashton Town in the FA Vase.
Lambeth Grove is the venue for Stockport Town v Maine Road after both teams won their respective FA Vase games last time to advance in the competition.