There were 26 registrations between 1/3/2022 and 7/3/2022. There were also 10 deregistrations. These have been coordinated by the NWCFL League Registrations Secretary, Rob Goodwin-Davey.
| Club | Player Name | Date Registered | Reg Type | Role |
| AFC Liverpool | Adam Garner | Thursday 3rd March 2022 | Non Contract | |
| AFC Liverpool | Finlay Heath | Friday 4th March 2022 | Non Contract | |
| Alsager Town | Michael Brennan | Friday 4th March 2022 | Non Contract | |
| Alsager Town | Daniel Moli | Tuesday 1st March 2022 | Non Contract | |
| Alsager Town | Charles Wilson | Wednesday 2nd March 2022 | Non Contract | |
| Atherton LR | Lewis Bradley | Friday 4th March 2022 | Non Contract | |
| Atherton LR | Connor Daly | Friday 4th March 2022 | Staff | Coach |
| Atherton LR | Craig Jones | Friday 4th March 2022 | Staff | Manager |
| Atherton LR | David Moore | Tuesday 1st March 2022 | Non Contract | |
| Atherton LR | Fenton Reeves | Wednesday 2nd March 2022 | Non Contract | |
| Avro | Oliver Froggatt | Friday 4th March 2022 | Non Contract | |
| Bacup Borough | Dennis Sherriff | Friday 4th March 2022 | Non Contract | |
| Barnton | Lukas Jacobsen-Murpy | Friday 4th March 2022 | Non Contract | |
| Brocton | Ethan Harris | Friday 4th March 2022 | Non Contract | |
| Brocton | Sam Hollinsworth | Thursday 3rd March 2022 | Non Contract | |
| Chadderton | Connor Seymour | Friday 4th March 2022 | Non Contract | |
| Congleton Town | Ryan Read | Friday 4th March 2022 | Non Contract | |
| Irlam | Shaquille Taylor-Alcide | Saturday 5th March 2022 | Non Contract | |
| Litherland REMYCA | Kieran Halligan | Friday 4th March 2022 | Non Contract | |
| Longridge Town | Justeace Holness | Tuesday 1st March 2022 | Non Contract | |
| Pilkington | James Farr | Tuesday 1st March 2022 | Non Contract | |
| Prestwich Heys | Keane Joyce | Friday 4th March 2022 | Non Contract | |
| Rocester | Michael Allen | Tuesday 1st March 2022 | Non Contract | |
| Rocester | Mawgan Blight | Friday 4th March 2022 | Non Contract | |
| Squires Gate | Kevin Burca | Tuesday 1st March 2022 | Non Contract | |
| Winsford United | Christopher Bradshaw | Tuesday 1st March 2022 | Non Contract |
| Club | Player Name | Date De-Registered | Reg Type | Role |
| Abbey Hey | Jake Parker | Saturday 5th March 2022 | Short Loan | |
| Alsager Town | Lewis Bradley | Saturday 5th March 2022 | Non Contract | |
| Alsager Town | Fenton Reeves | Wednesday 2nd March 2022 | Non Contract | |
| Ashton Athletic | Edward Servuts | Wednesday 2nd March 2022 | Non Contract | |
| Ashton Town | David Moore | Tuesday 1st March 2022 | Non Contract | |
| Daisy Hill | Connor Daly | Saturday 5th March 2022 | Staff | Coach |
| Lower Breck | Kieran Halligan | Saturday 5th March 2022 | Non Contract | |
| Sandbach United | Justeace Holness | Tuesday 1st March 2022 | Non Contract | |
| St Helens Town | Michael Brennan | Saturday 5th March 2022 | Non Contract | |
| Winsford United | Lukas Jacobsen-Murpy | Saturday 5th March 2022 | Non Contract |
