| Saturday 19th August 2000 | Premier Division | ||
|---|---|---|---|
| Maine Road | 1-2 | St Helens Town | |
| Tuesday 22nd August 2000 | Premier Division | ||
|---|---|---|---|
| Prescot Cables | 0-2 | Maine Road | |
| Saturday 26th August 2000 | Premier Division | ||
|---|---|---|---|
| Glossop North End | 1-4 | Maine Road | |
| Saturday 2nd September 2000 | F.A. Challenge Cup Preliminary Round | ||
|---|---|---|---|
| Maine Road | 2-2 | Easington Colliery | Att: 83 |
|
Tim Crane Anthony Hargreaves |
|||
| Tuesday 5th September 2000 | F.A. Challenge Cup Preliminary Round Replay | ||
|---|---|---|---|
| Easington Colliery | 3-2 | Maine Road | Att: 48 |
|
Jock Russell (43) Jock Russell (74) | |||
| Friday 8th September 2000 | Premier Division | ||
|---|---|---|---|
| Maine Road | 4-2 | Nantwich Town | |
| Saturday 16th September 2000 | Premier Division | ||
|---|---|---|---|
| Abbey Hey | 5-1 | Maine Road | |
| Tuesday 19th September 2000 | Premier Division | ||
|---|---|---|---|
| Maine Road | 0-1 | Rossendale United | |
| Saturday 23rd September 2000 | F.A. Carlsberg Vase 2nd Qualifying Round | ||
|---|---|---|---|
| Maine Road | 1-4 | Newcastle Benfield Saints | Att: 48 |
| Chris Simms | |||
| Tuesday 26th September 2000 | Premier Division | ||
|---|---|---|---|
| Atherton Collieries | 3-2 | Maine Road | |
| Saturday 30th September 2000 | Premier Division | ||
|---|---|---|---|
| Great Harwood Town | 1-6 | Maine Road | |
| Thursday 5th October 2000 | Premier Division | ||
|---|---|---|---|
| Nantwich Town | 3-1 | Maine Road | |
| Saturday 14th October 2000 | Premier Division | ||
|---|---|---|---|
| Maine Road | 3-2 | Cheadle Town | |
| Saturday 21st October 2000 | Premier Division | ||
|---|---|---|---|
| Maine Road | 2-3 | Glossop North End | |
| Tuesday 24th October 2000 | Premier Division | ||
|---|---|---|---|
| Kidsgrove Athletic | 2-1 | Maine Road | |
| Friday 27th October 2000 | Premier Division | ||
|---|---|---|---|
| Maine Road | 3-2 | Great Harwood Town | |
| Thursday 2nd November 2000 | Premier Division | ||
|---|---|---|---|
| Maine Road | 3-3 | Atherton Collieries | |
| Tuesday 28th November 2000 | League Challenge Cup 1st Round | ||
|---|---|---|---|
| Maine Road | 0-4 | Newcastle Town | Att: 35 |
|
Ray Walker (11) Dean Wilson-Cunningham (28) Bostock (40) Ray Walker (67) | |||
| Saturday 2nd December 2000 | Premier Division | ||
|---|---|---|---|
| Maine Road | 3-3 | Clitheroe | |
| Tuesday 5th December 2000 | Premier Division | ||
|---|---|---|---|
| Maine Road | 0-3 | Ramsbottom United | |
| Saturday 9th December 2000 | Premier Division | ||
|---|---|---|---|
| Cheadle Town | 0-2 | Maine Road | |
| Saturday 16th December 2000 | Premier Division | ||
|---|---|---|---|
| Maine Road | 0-1 | Newcastle Town | |
| Saturday 23rd December 2000 | Premier Division | ||
|---|---|---|---|
| Maine Road | 4-1 | Leek CSOB | |
| Tuesday 26th December 2000 | Premier Division | ||
|---|---|---|---|
| Salford City | 3-0 | Maine Road | |
| Saturday 6th January 2001 | Premier Division | ||
|---|---|---|---|
| Maine Road | 0-3 | Salford City | |
| Saturday 13th January 2001 | Premier Division | ||
|---|---|---|---|
| St Helens Town | 2-0 | Maine Road | |
| Friday 26th January 2001 | Premier Division | ||
|---|---|---|---|
| Maine Road | 2-0 | Woodley Sports | |
| Tuesday 30th January 2001 | Premier Division | ||
|---|---|---|---|
| Fleetwood Freeport | 4-3 | Maine Road | |
| Saturday 3rd February 2001 | Premier Division | ||
|---|---|---|---|
| Newcastle Town | 6-0 | Maine Road | |
| Saturday 10th February 2001 | Premier Division | ||
|---|---|---|---|
| Maine Road | 3-2 | Curzon Ashton | |
| Tuesday 13th February 2001 | Premier Division | ||
|---|---|---|---|
| Clitheroe | 3-0 | Maine Road | |
| Saturday 17th February 2001 | Premier Division | ||
|---|---|---|---|
| Maine Road | 5-2 | Abbey Hey | |
| Tuesday 20th February 2001 | Premier Division | ||
|---|---|---|---|
| Maine Road | 1-8 | Skelmersdale United | |
| Saturday 24th February 2001 | Premier Division | ||
|---|---|---|---|
| Mossley | 2-1 | Maine Road | |
| Friday 2nd March 2001 | Premier Division | ||
|---|---|---|---|
| Maine Road | 3-4 | Fleetwood Freeport | |
| Saturday 10th March 2001 | Premier Division | ||
|---|---|---|---|
| Skelmersdale United | 1-2 | Maine Road | |
| Tuesday 13th March 2001 | Premier Division | ||
|---|---|---|---|
| Curzon Ashton | 2-3 | Maine Road | |
| Saturday 17th March 2001 | Premier Division | ||
|---|---|---|---|
| Maine Road | 2-4 | Prescot Cables | |
| Saturday 24th March 2001 | Premier Division | ||
|---|---|---|---|
| Woodley Sports | 3-0 | Maine Road | |
| Monday 2nd April 2001 | Premier Division | ||
|---|---|---|---|
| Maine Road | 1-3 | Kidsgrove Athletic | |
| Tuesday 10th April 2001 | Premier Division | ||
|---|---|---|---|
| Ramsbottom United | 6-1 | Maine Road | |
| Saturday 14th April 2001 | Premier Division | ||
|---|---|---|---|
| Flixton | 3-1 | Maine Road | |
| Saturday 21st April 2001 | Premier Division | ||
|---|---|---|---|
| Rossendale United | 2-0 | Maine Road | |
| Saturday 28th April 2001 | Premier Division | ||
|---|---|---|---|
| Maine Road | 0-0 | Mossley | |
| Tuesday 8th May 2001 | Premier Division | ||
|---|---|---|---|
| Maine Road | 3-0 | Flixton | |
| Monday 14th May 2001 | Premier Division | ||
|---|---|---|---|
| Leek CSOB | 1-2 | Maine Road | |
