Two NWCFL Premier Division sides meet in the First Qualifying Round of the FA Cup when Irlam travel to Mossie Park to face Charnock Richard.
Charnock have won their last two, including a replay victory over Longridge Town in the last round of the FA Cup, while Irlam are unbeaten in their opening month of the season.
Premier Division club of the month for August Whitchurch Alport face a home tie against Leek Town after they defeated Coleshill Town in the last round.
After a late turnaround in their midweek replay with Radcliffe Borough, Runcorn Town's reward for their stunning win is a trip to Newcastle Benfield on Saturday.
Northwich Victoria haven't played since their 8-0 victory over Litherland REMYCA on Bank Holiday Monday, and after overcoming Prescot Cables in the last round they face a trip to Lancaster City.
1874 Northwich will welcome Pickering Town on Saturday after beating Handsworth Parramore 6-0 in the last round.