| Tue 24/09/24 | Burscough v Pilkington * | 3-2 | | | | | | |
| Sat 28/09/24 | Pilkington v Charnock Richard | 1-0 | |  | |  | | |
| Sat 05/10/24 | Pilkington v Irlam | 1-3 | | | | | | |
| Wed 09/10/24 | South Liverpool v Pilkington * | 0-0 | | | | | | |
| Sat 12/10/24 | Colne v Pilkington | 2-4 |  | | | | | |
| Sat 19/10/24 | Pilkington v Prestwich Heys | - | | | | | | |
| Sat 02/11/24 | Bury v Pilkington | 2-0 | | | | | | |
| Sat 09/11/24 | Pilkington v Prestwich Heys | 3-2 | | | | | |  |
| Sat 16/11/24 | Ramsbottom United v Pilkington * | 2-0 | | | | | | |
| Sat 23/11/24 | Pilkington v FC Isle of Man | 3-3 | | | | | | |
| Wed 27/11/24 | Pilkington v South Liverpool | 4-3 | | | | | | |
| Sat 30/11/24 | Pilkington v Abbey Hey | 4-1 | | | | | | |
| Tue 03/12/24 | Prescot Cables v Pilkington (CUP) * | 4-1 | | | | | | |
| Sat 14/12/24 | Pilkington v Glossop North End | 1-3 | | | | | | |
| Sat 21/12/24 | Cheadle Town v Pilkington | 4-0 | | | | | | |
| Sat 04/01/25 | Pilkington v Burscough * | 2-2 | | | | | | |
| Tue 07/01/25 | Squires Gate v Pilkington * | 3-4 | | | | | | |
| Sat 18/01/25 | Pilkington v Stockport Town * | 0-3 | | | | | | |
| Thu 23/01/25 | Lower Breck v Pilkington | 5-0 | | | | | | |
| Sat 25/01/25 | Pilkington v Padiham * | 1-3 | | | | | | |
| Sat 01/02/25 | AFC Liverpool v Pilkington | 2-0 | | | | | | |
| Sat 08/02/25 | Pilkington v FC St Helens | 0-1 | | | | | | |
| Sat 15/02/25 | Prestwich Heys v Pilkington * | 2-2 | | | | | | |
| Sat 22/02/25 | West Didsbury & Chorlton v Pilkington | 3-1 | | | | | | |
| Sat 01/03/25 | Pilkington v Barnoldswick Town | 2-0 | | | | | | |
| Sat 08/03/25 | Stockport Town v Pilkington | 2-1 | | | | | | |
| Sat 15/03/25 | FC Isle of Man v Pilkington | 3-3 | | | | | | |
| Sat 22/03/25 | Pilkington v Bury | 0-2 | | | | | | |
| Sat 29/03/25 | Longridge Town v Pilkington | 0-2 | | | | | | |
| Fri 04/04/25 | Chadderton v Pilkington | 4-1 | | | | | | |
| Sat 12/04/25 | Pilkington v Squires Gate | 3-1 | | | | | | |
| Sat 19/04/25 | Glossop North End v Pilkington | 4-0 | | | | | | |
