| Sat 18/09/21 | Cheadle Town v Stafford Town * | 3-0 | | | | | |
| Sat 25/09/21 | Stafford Town v Studley * | 0-2 | | | | | |
| Tue 28/09/21 | Stafford Town v Brocton * | 4-1 |  | | | | |
| Sat 02/10/21 | Wythenshawe Amateurs v Stafford Town | 5-0 | | | | | |
| Sat 09/10/21 | Stafford Town v Sandbach United * | 4-2 | | | | | |
| Sat 16/10/21 | Stafford Town v Stockport Town * | 1-0 | | | | | |
| Sat 23/10/21 | New Mills v Stafford Town * | 5-1 | | | | | |
| Sat 30/10/21 | Stafford Town v Abbey Hey * | 2-1 | | | | | |
| Sat 13/11/21 | Cheadle Heath Nomads v Stafford Town * | 1-1 | | | | | |
| Sat 27/11/21 | Stockport Town v Stafford Town * | 3-0 | | | | | |
| Tue 30/11/21 | Stafford Town v Stafford Rangers * | 0-1 | | | | | |
| Sat 04/12/21 | Stafford Town v Cheadle Heath Nomads * | 3-3 | | |  | | |
| Sat 11/12/21 | West Didsbury & Chorlton v Stafford Town * | 0-0 | | | | | |
| Sat 18/12/21 | Stafford Town v Rocester | 4-0 | | | | | |
| Sat 15/01/22 | Stafford Town v Eccleshall | 1-1 | | | | | |
| Sat 22/01/22 | Cammell Laird 1907 v Stafford Town | 2-1 | | | | | |
| Sat 29/01/22 | Stafford Town v Wythenshawe Amateurs * | 0-6 | | | | | |
| Tue 01/02/22 | Stafford Town v Maine Road * | 0-2 | | | | | |
| Sat 05/02/22 | Barnton v Stafford Town * | 1-2 | | | | | |
| Sat 12/02/22 | Abbey Hulton United v Stafford Town | - | | | | | |
| Sat 19/02/22 | Stafford Town v FC Isle of Man | 1-5 | | | | | |
| Tue 22/02/22 | Stafford Town v Brocton | 4-1 | | | | | |
| Sat 26/02/22 | Abbey Hey v Stafford Town | 6-0 | | | | | |
| Sat 05/03/22 | Stafford Town v New Mills | 1-3 | | | | | |
| Sat 12/03/22 | Ellesmere Rangers v Stafford Town | 1-0 | | | | | |
| Sat 19/03/22 | Alsager Town v Stafford Town | 0-1 | | | | | |
| Sat 26/03/22 | Stafford Town v Cheadle Town * | 4-3 | | | | | |
| Sat 02/04/22 | Brocton v Stafford Town * | 1-0 | | | | | |
| Tue 05/04/22 | Stafford Town v Eccleshall | 2-0 | | | | | |
| Sat 09/04/22 | Congleton Town v Stafford Town | 4-0 | | | | | |
