| 11/09/21 | Winterton Rngers 3-2 Macclesfield |
| 14/09/21 | Macclesfield 1-0 Vauxhall Mtrs |
| 18/09/21 | Macclesfield 4-0 Litherland REMY |
| 20/09/21 | Longridge Town 4-2 Macclesfield |
| 29/09/21 | Avro 2-0 Macclesfield
MoM |
| 02/10/21 | Macclesfield 4-1 Charnock Richard
1 goal |
| 05/10/21 | Macclesfield 2-1 Northwich Vics |
| 09/10/21 | Wythenshawe Town 0-1 Macclesfield |
| 16/10/21 | Squires Gate 0-0 Macclesfield |
| 23/10/21 | Macclesfield 3-0 Padiham |
| 29/10/21 | Lower Breck 1-3 Macclesfield
2 goals , MoM |
| 06/11/21 | Macclesfield 2-2 Runcorn Town
2 goals |
| 09/11/21 | AFC Liverpool 1-2 Macclesfield
1 goal |
| 13/11/21 | Skelmersdale Utd 0-0 Macclesfield
MoM |
| 27/11/21 | Northwich Vics 3-4 Macclesfield
, Yellow Card , MoM |
| 04/12/21 | Macclesfield 2-0 Barnoldswick Town |
| 11/12/21 | Macclesfield 1-0 Squires Gate |
| 27/12/21 | Macclesfield 2-1 Winsford United
1 goal , MoM |
| 03/01/22 | Prestwich Heys 1-0 Macclesfield |
| 08/01/22 | Macclesfield 2-4 Wythenshawe Town |
| 14/01/22 | Litherland REMY 1-2 Macclesfield
1 goal |
| 22/01/22 | Charnock Richard 1-1 Macclesfield
1 goal |
| 29/01/22 | Macclesfield 3-1 Skelmersdale Utd
1 goal |
| 05/02/22 | Padiham - Macclesfield |
| 08/02/22 | Irlam 2-2 Macclesfield
1 goal |
| 12/02/22 | Macclesfield 4-0 Lower Breck
1 goal |
| 19/02/22 | Burscough 0-4 Macclesfield
2 goals , MoM |
| 22/02/22 | Vauxhall Mtrs 0-6 Macclesfield
2 goals , MoM |
| 26/02/22 | Runcorn Town 0-1 Macclesfield |
| 05/03/22 | Macclesfield 3-1 Longridge Town |
| 08/03/22 | Padiham 0-2 Macclesfield
1 goal |
| 12/03/22 | Macclesfield 4-0 Ashton Athletic
1 goal |
| 02/04/22 | Macclesfield 4-2 AFC Liverpool |
| 02/05/22 | Skelmersdale Utd 3-2 Macclesfield
1 goal |
