| Mon 30/08/21 | St Martins v Ellesmere Rangers | 0-8 |  | | | |  |
| Sat 04/09/21 | Ellesmere Rangers v New Mills * | 1-3 | | | | | |
| Sat 11/09/21 | Ellesmere Rangers v Wythenshawe Amateurs | 1-1 | | | | | |
| Sat 18/09/21 | Maine Road v Ellesmere Rangers * | 3-2 | | | | | |
| Sat 02/10/21 | Ellesmere Rangers v FC Isle of Man * | 2-3 | | | | | |
| Sat 09/10/21 | Ellesmere Rangers v Cheadle Heath Nomads | 3-3 | | | | | |
| Sat 16/10/21 | West Didsbury & Chorlton v Ellesmere Rangers | 1-1 | | | | | |
| Sat 23/10/21 | Ellesmere Rangers v Alsager Town | 3-3 | | | | | |
| Sat 30/10/21 | Ellesmere Rangers v Abbey Hulton United | 4-2 | | | | | |
| Sat 06/11/21 | Cheadle Town v Ellesmere Rangers | 7-1 | | | | | |
| Tue 09/11/21 | Ellesmere Rangers v Rocester * | 2-3 | | | | | |
| Sat 13/11/21 | Ellesmere Rangers v Abbey Hey * | 1-2 | | | | | |
| Sat 20/11/21 | Eccleshall v Ellesmere Rangers * | 2-3 | | | | | |
| Sat 27/11/21 | Ellesmere Rangers v Barnton | 0-2 | | | | | |
| Sat 04/12/21 | Wythenshawe Amateurs v Ellesmere Rangers | - | |  | | | |
| Tue 14/12/21 | Wythenshawe Amateurs v Ellesmere Rangers * | 5-0 | | | | | |
| Sat 18/12/21 | Ellesmere Rangers v West Didsbury & Chorlton | 1-0 | | | | | |
| Mon 27/12/21 | Ellesmere Rangers v St Martins | 7-0 | | | | | |
| Sat 15/01/22 | FC Isle of Man v Ellesmere Rangers * | 3-0 | | | | | |
| Sat 05/02/22 | Sandbach United v Ellesmere Rangers | 4-1 | | | | | |
| Sat 12/02/22 | Ellesmere Rangers v Stockport Town | 1-3 | | |  | | |
| Tue 22/02/22 | St Martins v Ellesmere Rangers | 0-5 | | | | | |
| Sat 26/02/22 | Abbey Hulton United v Ellesmere Rangers * | 1-0 | | | | | |
| Sat 12/03/22 | Ellesmere Rangers v Stafford Town * | 1-0 | | | | | |
| Sat 19/03/22 | Cheadle Heath Nomads v Ellesmere Rangers | 1-1 | | | | | |
| Sat 26/03/22 | Abbey Hey v Ellesmere Rangers | 2-1 | | | | | |
| Thu 31/03/22 | Ellesmere Rangers v Maine Road | 3-5 | | | | | |
| Tue 05/04/22 | Ellesmere Rangers v Sandbach United | 2-3 | | | | | |
