Sat 07/08/21 | Macclesfield v Burscough | 4-0 | | | | | |
Sat 14/08/21 | Macclesfield v Irlam | 2-1 | | |  | | |
Tue 17/08/21 | Macclesfield v Prestwich Heys | 3-1 | | | | | |
Sat 21/08/21 | Squires Gate v Macclesfield | 6-4 |  | | | | |
Sat 28/08/21 | Barnoldswick Town v Macclesfield | 1-2 | | | | | |
Mon 30/08/21 | Macclesfield v Congleton Town | 1-0 | | | | | |
Sat 04/09/21 | Ashton Athletic v Macclesfield | 1-1 |  | |  | | |
Sat 11/09/21 | Winterton Rangers v Macclesfield | 3-2 |  | | | | |
Tue 14/09/21 | Macclesfield v Vauxhall Motors | 1-0 | | | | | |
Sat 18/09/21 | Macclesfield v Litherland REMYCA * | 4-0 | | | | | |
Mon 20/09/21 | Longridge Town v Macclesfield | 4-2 | | | | | |
Wed 29/09/21 | Avro v Macclesfield | 2-0 | | | | | |
Sat 02/10/21 | Macclesfield v Charnock Richard | 4-1 |  | | | | |
Tue 05/10/21 | Macclesfield v Northwich Victoria | 2-1 | | | | | |
Sat 09/10/21 | Wythenshawe Town v Macclesfield * | 0-1 | | | | | |
Sat 23/10/21 | Macclesfield v Padiham | 3-0 | | | | | |
Fri 29/10/21 | Lower Breck v Macclesfield * | 1-3 |  | | | | |
Sat 06/11/21 | Macclesfield v Runcorn Town | 2-2 | | | | | |
Sat 27/11/21 | Northwich Victoria v Macclesfield * | 3-4 | | | | | |
Sat 04/12/21 | Macclesfield v Barnoldswick Town | 2-0 | | | | |  |
Sat 11/12/21 | Macclesfield v Squires Gate | 1-0 | | | | | |
Mon 03/01/22 | Prestwich Heys v Macclesfield * | 1-0 | | | | | |
Fri 14/01/22 | Litherland REMYCA v Macclesfield | 1-2 | | | | | |
Sat 22/01/22 | Charnock Richard v Macclesfield * | 1-1 | | | | | |
Sat 29/01/22 | Macclesfield v Skelmersdale United * | 3-1 | | | | | |
Sat 12/02/22 | Macclesfield v Lower Breck * | 4-0 | | | | | |
Tue 22/02/22 | Vauxhall Motors v Macclesfield * | 0-6 |  | | | | |
Sat 26/02/22 | Runcorn Town v Macclesfield * | 0-1 | | | | | |
Sat 05/03/22 | Macclesfield v Longridge Town * | 3-1 |  | | | | |