| Sat 30/07/22 | Irlam v Wythenshawe Town * | 1-3 | | | | | |
| Sat 06/08/22 | Wythenshawe Town v Macclesfield | 0-2 | | | | | |
| Sat 13/08/22 | Kendal Town v Wythenshawe Town * | 1-3 | | | | | |
| Wed 17/08/22 | Litherland REMYCA v Wythenshawe Town | 1-3 | | | | | |
| Sat 03/09/22 | Squires Gate v Wythenshawe Town | 1-3 | | | | | |
| Tue 06/09/22 | Wythenshawe Town v Burscough * | 5-0 | | | | | |
| Tue 13/09/22 | Wythenshawe Town v Longridge Town * | 3-1 | | | | | |
| Sat 17/09/22 | Wythenshawe Town v Winsford United | 7-0 | | | | | |
| Sat 24/09/22 | Avro v Wythenshawe Town | 0-2 | | |  | | |
| Tue 27/09/22 | Wythenshawe Town v Charnock Richard * | 3-0 | | | | | |
| Sat 01/10/22 | Vauxhall Motors v Wythenshawe Town * | 0-0 | | | | | |
| Sat 08/10/22 | Wythenshawe Town v Squires Gate * | 6-0 | | | | | |
| Tue 11/10/22 | Wythenshawe Town v Bury AFC | 3-0 |  | | | | |
| Sat 15/10/22 | Wythenshawe Town v Northwich Victoria * | 3-0 | | | | | |
| Tue 18/10/22 | Wythenshawe Town v Congleton Town * | 2-1 | | | | | |
| Sat 22/10/22 | Padiham v Wythenshawe Town * | 2-2 | | | | | |
| Tue 25/10/22 | Wythenshawe Town v FC Isle of Man * | 2-2 | | | | | |
| Thu 03/11/22 | Lower Breck v Wythenshawe Town * | 4-0 | | | | | |
| Sat 05/11/22 | AFC Liverpool v Wythenshawe Town * | 1-3 | | | | | |
| Tue 15/11/22 | Wythenshawe Town v Barnoldswick Town * | 2-3 | | | | | |
| Sat 19/11/22 | Wythenshawe Town v AFC Liverpool * | 5-1 | | | | | |
| Sat 26/11/22 | Ashton Athletic v Wythenshawe Town * | 1-7 | | | | | |
| Tue 06/12/22 | Wythenshawe Town v Irlam * | 1-3 | | | | | |
| Sat 04/02/23 | Winsford United v Wythenshawe Town * | 1-1 | | | | | |
| Tue 07/02/23 | Ashton United v Wythenshawe Town | 0-2 | | | | | |
| Sat 11/02/23 | Wythenshawe Town v Padiham | 0-1 | | | | | |
| Sat 18/02/23 | Wythenshawe Town v Litherland REMYCA | 3-0 | | | | | |
| Sat 25/02/23 | West Didsbury & Chorlton v Wythenshawe Town | 0-2 | | | | | |
| Wed 01/03/23 | Bury AFC v Wythenshawe Town | 1-3 | | | | |  |
| Tue 07/03/23 | Wythenshawe Town v Avro | 1-3 | | | | | |
| Sat 11/03/23 | Burscough v Wythenshawe Town * | 4-5 | | | | | |
| Sat 18/03/23 | Wythenshawe Town v AFC Liverpool * | 4-0 | | | | | |
| Tue 21/03/23 | Wythenshawe Town v Kendal Town * | 5-2 | | | | | |
| Sat 25/03/23 | Wythenshawe Town v Lower Breck * | 2-0 | | | | | |
| Tue 04/04/23 | Prestwich Heys v Wythenshawe Town * | 0-2 | | | | | |
| Tue 18/04/23 | Wythenshawe Town v Radcliffe * | 0-3 | | | | | |
| Sat 22/04/23 | FC Isle of Man v Wythenshawe Town * | 3-1 | | | | | |
