| Sat 30/07/22 | Eccleshall v Cammell Laird 1907 | 1-0 | | | | | |
| Sat 06/08/22 | Cammell Laird 1907 v Cheadle Town | 1-3 |  | |  | | |
| Mon 08/08/22 | Maine Road v Cammell Laird 1907 | 3-3 | | | | | |
| Sat 27/08/22 | Wythenshawe Amateurs v Cammell Laird 1907 * | 1-1 | | | | | |
| Mon 29/08/22 | Stockport Georgians v Cammell Laird 1907 | 3-0 | | | | | |
| Sat 03/09/22 | Cammell Laird 1907 v Stafford Town | 0-3 | | | | | |
| Tue 06/09/22 | Cammell Laird 1907 v Cheadle Heath Nomads | 3-3 | | | | | |
| Tue 13/09/22 | Cammell Laird 1907 v Ellesmere Rangers | 0-5 | | | | | |
| Sat 08/10/22 | Cammell Laird 1907 v Abbey Hey * | 1-2 | | | | | |
| Sat 15/10/22 | Cammell Laird 1907 v Ashville | 2-1 | | | | | |
| Sat 22/10/22 | Squires Gate v Cammell Laird 1907 | 2-1 | | | | | |
| Sat 29/10/22 | Stafford Town v Cammell Laird 1907 | 1-2 | | | | | |
| Sat 05/11/22 | Cammell Laird 1907 v Foley Meir | 5-1 | | | | |  |
| Sat 12/11/22 | Cammell Laird 1907 v Maine Road * | 4-3 | | | | | |
| Sat 19/11/22 | Cammell Laird 1907 v South Liverpool | 1-4 | | | | | |
| Tue 22/11/22 | Cammell Laird 1907 v Sutton Athletic * | 2-0 | | | | | |
| Wed 30/11/22 | Cammell Laird 1907 v Abbey Hey | 0-3 | | | | | |
| Sat 03/12/22 | Cammell Laird 1907 v Alsager Town | 2-0 | | | | | |
| Sat 14/01/23 | Wythenshawe Amateurs v Cammell Laird 1907 | 2-1 | | | | | |
| Tue 24/01/23 | Cammell Laird 1907 v Barnton | 0-2 | | | | | |
| Tue 31/01/23 | Foley Meir v Cammell Laird 1907 * | 2-2 | | | | | |
| Sat 04/02/23 | Cammell Laird 1907 v Stockport Georgians | 1-3 | |  | | | |
| Tue 07/02/23 | Abbey Hulton United v Cammell Laird 1907 | 2-1 | | | | | |
| Tue 14/02/23 | Cammell Laird 1907 v Higher Bebington Kelma | 1-1 | | | | | |
| Sat 25/02/23 | Cammell Laird 1907 v Rocester | 2-1 | | | | | |
| Tue 28/02/23 | Cammell Laird 1907 v Sandbach United | 2-3 | | | | | |
| Sat 04/03/23 | Capenhurst Villa v Cammell Laird 1907 | 2-0 | | | | | |
| Sat 25/03/23 | Cammell Laird 1907 v Abbey Hulton United | 2-2 | | | | | |
| Sat 15/04/23 | Ellesmere Rangers v Cammell Laird 1907 | 4-2 | | | | | |
