| Sat 31/07/21 | Rocester v Eccleshall | 2-1 | | | | | |
| Tue 03/08/21 | Abbey Hulton United v Rocester | 2-1 | | | | | |
| Sat 07/08/21 | Rocester v Cheadle Town | 1-2 | | | | | |
| Sat 14/08/21 | Maine Road v Rocester | 3-1 | | | | | |
| Sat 04/09/21 | Rocester v Sandbach United | 2-1 | | |  | | |
| Tue 07/09/21 | Rocester v Alsager Town * | 0-2 | | | | | |
| Sat 11/09/21 | AFC Bridgnorth v Rocester | 2-1 | | | | | |
| Sat 18/09/21 | Rocester v Barnton * | 0-1 | | | | | |
| Sat 02/10/21 | St Martins v Rocester | 0-4 | | | | | |
| Sat 09/10/21 | Rocester v Wythenshawe Amateurs | 0-4 | | | | | |
| Sat 23/10/21 | Rocester v West Didsbury & Chorlton | 0-2 | | | | |  |
| Sat 06/11/21 | Abbey Hey v Rocester | 2-1 | | | | | |
| Tue 09/11/21 | Ellesmere Rangers v Rocester * | 2-3 | | | | | |
| Sat 13/11/21 | FC Isle of Man v Rocester | 2-1 | | | | | |
| Sat 20/11/21 | Cheadle Town v Rocester | 3-0 | | | | | |
| Tue 30/11/21 | Rocester v New Mills * | 1-4 | | | | | |
| Sat 04/12/21 | Eccleshall v Rocester * | 1-1 | | | | | |
| Sat 11/12/21 | Rocester v FC Isle of Man | 2-2 | | | | | |
| Sat 18/12/21 | Stafford Town v Rocester | 4-0 | | | | | |
| Tue 11/01/22 | Rocester v Cammell Laird 1907 * | 1-5 | | | | | |
| Tue 18/01/22 | Kidsgrove Athletic v Rocester | 5-0 | | | | | |
| Sat 22/01/22 | Barnton v Rocester | 4-1 | | | | | |
| Sat 29/01/22 | Rocester v St Martins | 4-0 | | | | | |
| Tue 08/02/22 | Rocester v Ellesmere Rangers | 2-2 | | | | | |
| Tue 01/03/22 | Rocester v Cheadle Heath Nomads * | 2-0 | | | | | |
| Sat 05/03/22 | Rocester v Abbey Hulton United * | 2-4 | | | | | |
| Tue 08/03/22 | West Didsbury & Chorlton v Rocester | 5-1 | | | | | |
| Sat 12/03/22 | Rocester v Maine Road | 1-4 | | | | | |
| Tue 15/03/22 | Rocester v Abbey Hey | 1-2 | | | | | |
| Thu 17/03/22 | Congleton Town v Rocester | 5-0 | | | | | |
| Sat 19/03/22 | Stockport Town v Rocester | 2-2 | |  | | | |
| Tue 22/03/22 | New Mills v Rocester | 5-0 | | | | | |
| Sat 02/04/22 | Wythenshawe Amateurs v Rocester | 3-1 | | | | | |
| Tue 05/04/22 | Abbey Hulton United v Rocester | 1-0 | | | | | |
