| Sat 16/08/25 | Pilkington v South Liverpool * | 1-6 | | | | | | |
| Sat 06/09/25 | South Liverpool v West Didsbury & Chorlton * | 0-1 | | | | | | |
| Sat 13/09/25 | Prestwich Heys v South Liverpool | 3-0 | | | | | | |
| Wed 17/09/25 | South Liverpool v Abbey Hey | 5-3 | | | | | | |
| Wed 08/10/25 | South Liverpool v FC Isle of Man | 3-1 | | | | | | |
| Sat 18/10/25 | Northallerton Town v South Liverpool (CUP) | 1-2 | | | | | | |
| Tue 28/10/25 | AFC Liverpool v South Liverpool | 1-1 | | | | | | |
| Wed 05/11/25 | South Liverpool v Charnock Richard | 3-0 | |  | | | | |
| Sat 08/11/25 | South Liverpool v Barton Town (CUP) | 4-0 | | | | | | |
| Sat 22/11/25 | South Liverpool v Irlam | 0-3 | | | | | | |
| Wed 10/12/25 | Litherland REMYCA v South Liverpool (CUP) | 1-4 |  | | | | | |
| Sat 13/12/25 | Barnoldswick Town v South Liverpool | 0-0 | | | | | | |
| Wed 17/12/25 | South Liverpool v Cheadle Town | 2-2 | | | | | | |
| Sat 20/12/25 | South Liverpool v Padiham | 1-0 | | | | | | |
| Sat 03/01/26 | South Liverpool v Wythenshawe | 1-3 | | | | | | |
| Tue 13/01/26 | Burscough v South Liverpool | 5-2 | | | | | | |
| Sat 17/01/26 | South Liverpool v Winsford United (CUP) | 2-5 | | | | | | |
| Sat 24/01/26 | FC Isle of Man v South Liverpool | 3-2 | | | | | |  |
| Wed 28/01/26 | South Liverpool v Pilkington | 3-1 | | | | | | |
| Wed 04/02/26 | South Liverpool v Ramsbottom United * | 0-2 | | | | | | |
| Sat 07/02/26 | South Liverpool v Longridge Town | 2-2 | | | | | | |
| Wed 18/02/26 | West Didsbury & Chorlton v South Liverpool | 4-0 | | | | | | |
| Sat 21/02/26 | South Liverpool v Barnoldswick Town * | 3-1 | | | | | | |
| Sat 21/03/26 | South Liverpool v Prestwich Heys * | 0-2 | | | | | | |
