| Sat 06/08/22 | Silsden v Burscough | 1-0 | | | | | |
| Tue 09/08/22 | Burscough v AFC Liverpool | 1-6 | | | | | |
| Sat 13/08/22 | Padiham v Burscough | 0-2 |  | | | | |
| Thu 18/08/22 | Lower Breck v Burscough | 2-0 | | | | | |
| Sun 21/08/22 | Burscough v Barnoldswick Town | 2-3 | | | | |  |
| Wed 24/08/22 | Burscough v Kendal Town | 2-4 | | |  | | |
| Sat 27/08/22 | Burscough v Bacup Borough | 3-3 | | | | | |
| Mon 29/08/22 | Vauxhall Motors v Burscough | 5-0 | | | | | |
| Tue 06/09/22 | Wythenshawe Town v Burscough | 5-0 | | | | | |
| Thu 08/09/22 | Burscough v Longridge Town | 3-1 | | | | | |
| Tue 13/09/22 | Burscough v Avro | 1-3 | | | | | |
| Sat 24/09/22 | Northwich Victoria v Burscough | 3-1 | | | | | |
| Tue 27/09/22 | Burscough v West Didsbury & Chorlton | 1-6 | | | | | |
| Sat 01/10/22 | Burscough v Irlam | 2-3 | | | | | |
| Tue 04/10/22 | Burscough v FC Isle of Man | 4-7 | | | | | |
| Sat 08/10/22 | Winsford United v Burscough | 3-2 | | | | | |
| Tue 11/10/22 | Congleton Town v Burscough | 2-0 | | | | | |
| Sat 15/10/22 | Holker Old Boys v Burscough | 1-1 | | | | | |
| Tue 25/10/22 | Burscough v City of Liverpool | 2-2 | | | | | |
| Sat 05/11/22 | Burscough v Lower Breck * | 0-0 | | | | | |
| Tue 08/11/22 | Burscough v Ashton Athletic * | 1-1 | | | | | |
| Sat 26/11/22 | Burscough v Prestwich Heys * | 3-1 | | | | | |
| Mon 26/12/22 | Squires Gate v Burscough | 1-3 | | | | | |
| Mon 02/01/23 | FC Isle of Man v Burscough | 3-4 | | | | | |
| Sat 07/01/23 | Litherland REMYCA v Burscough | 2-1 | | | | | |
| Sat 14/01/23 | Burscough v Charnock Richard | 3-2 | | | | | |
| Tue 24/01/23 | Burscough v Winsford United | 0-0 | | | | | |
| Sat 28/01/23 | Burscough v Padiham | 0-2 | | | | | |
| Wed 01/02/23 | Avro v Burscough | 3-0 | | | | | |
| Sat 04/02/23 | West Didsbury & Chorlton v Burscough | 3-1 | | | | | |
| Sat 11/02/23 | Burscough v Litherland REMYCA | 2-3 | | | | | |
| Sat 18/02/23 | Irlam v Burscough | 1-2 | | | | | |
| Sat 25/02/23 | Burscough v Bury AFC | 0-1 | | | | | |
| Sat 04/03/23 | Barnoldswick Town v Burscough | 1-1 | | | | | |
| Sat 11/03/23 | Burscough v Wythenshawe Town | 4-5 | | | | | |
| Sat 18/03/23 | Burscough v Vauxhall Motors | 0-1 | | | | | |
