| Sat 31/07/21 | Irlam v Litherland REMYCA | 1-0 | | | | | |
| Tue 03/08/21 | Irlam v Congleton Town | 0-3 | | | | | |
| Sat 07/08/21 | Irlam v Albion Sports | 3-0 | | | | | |
| Wed 18/08/21 | Avro v Irlam | 3-0 | | | | | |
| Sat 28/08/21 | Irlam v Runcorn Town | 2-2 | | | | | |
| Mon 30/08/21 | Winsford United v Irlam * | 1-7 | | | | | |
| Tue 07/09/21 | Irlam v Wythenshawe Town * | 2-0 | | | | | |
| Sat 18/09/21 | Longridge Town v Irlam * | 1-3 | | | | | |
| Tue 21/09/21 | Irlam v Barnoldswick Town * | 0-3 | | | | | |
| Sat 25/09/21 | Burscough v Irlam | 2-0 | | | | | |
| Tue 28/09/21 | Irlam v Skelmersdale United | 1-0 | | | | | |
| Tue 05/10/21 | Prestwich Heys v Irlam * | 0-2 | | | | | |
| Tue 12/10/21 | Squires Gate v Irlam * | 2-5 | | | | | |
| Tue 19/10/21 | Irlam v Mossley | 1-2 | | | | | |
| Sat 23/10/21 | Irlam v Lower Breck | 1-4 | | | | | |
| Sat 30/10/21 | Ashton Athletic v Irlam | 2-0 | | | | | |
| Sat 06/11/21 | Irlam v Charnock Richard * | 0-1 | | | | | |
| Sat 13/11/21 | Irlam v AFC Liverpool | 0-4 | | |  | |  |
| Sat 20/11/21 | Lower Breck v Irlam | 4-0 | | | | | |
| Sat 27/11/21 | Irlam v Winsford United | 3-0 | | | | | |
| Fri 17/12/21 | Irlam v Padiham | 0-1 | | | | | |
| Sat 15/01/22 | Barnoldswick Town v Irlam * | 2-2 | | | | | |
| Sat 22/01/22 | Irlam v Burscough * | 2-1 | | | | | |
| Fri 28/01/22 | Litherland REMYCA v Irlam * | 2-3 | | | | | |
| Tue 01/02/22 | Runcorn Town v Irlam * | 1-2 | | | | | |
| Sat 05/02/22 | Vauxhall Motors v Irlam * | 1-2 | | | | | |
| Tue 08/02/22 | Irlam v Macclesfield * | 2-2 | | | | | |
| Sat 12/02/22 | Irlam v Avro * | 2-1 | | | | | |
| Sat 26/02/22 | Skelmersdale United v Irlam * | 2-0 | | | | | |
| Sat 05/03/22 | Congleton Town v Irlam * | 1-1 | | | | | |
| Tue 15/03/22 | Irlam v Longridge Town | 3-1 |  | | | | |
| Sat 19/03/22 | AFC Liverpool v Irlam | 0-2 | | | | | |
| Tue 22/03/22 | Charnock Richard v Irlam | 2-1 | | | | | |
| Sat 26/03/22 | Irlam v Northwich Victoria | 1-3 | | | | | |
| Wed 30/03/22 | Barnton v Irlam | 2-1 | | | | | |
| Sat 02/04/22 | Irlam v Ashton Athletic | 1-1 | | | | | |
