| Sat 26/07/25 | Glossop North End v City of Liverpool | 2-2 |  | | |  | | |
| Tue 29/07/25 | Glossop North End v West Didsbury & Chorlton | 1-2 | | | | | | |
| Sat 02/08/25 | Glossop North End v FC St Helens (CUP) | 1-1 | | | | | | |
| Tue 05/08/25 | FC St Helens v Glossop North End (CUP) | 3-1 | | | | | | |
| Sat 09/08/25 | FC Isle of Man v Glossop North End | 2-3 | | | | | | |
| Tue 12/08/25 | Glossop North End v Wythenshawe | 2-2 | | | | | | |
| Sat 23/08/25 | Glossop North End v Bacup Borough (CUP) | 1-1 | | | | | | |
| Mon 25/08/25 | Abbey Hey v Glossop North End | 2-0 | | | | | | |
| Sat 30/08/25 | Glossop North End v South Liverpool | 0-1 | | | | | | |
| Sat 06/09/25 | Glossop North End v Pilkington | 0-4 | | | | | | |
| Sat 13/09/25 | Litherland REMYCA v Glossop North End * | 1-2 | | | | | | |
| Tue 16/09/25 | Glossop North End v Prestwich Heys * | 1-2 | | | | | | |
| Sat 20/09/25 | West Didsbury & Chorlton v Glossop North End | 1-2 | | | | | | |
| Tue 23/09/25 | Cheadle Town v Glossop North End | 0-1 | |  | | | | |
| Sat 27/09/25 | Cheadle Town v Glossop North End (CUP) | 3-2 | | | | | | |
| Tue 30/09/25 | Glossop North End v Atherton LR | 0-2 | | | | | | |
| Sat 04/10/25 | Glossop North End v Chadderton | 0-3 | | | | | | |
| Tue 07/10/25 | Glossop North End v Stockport Town | 1-2 | | | | | | |
| Sat 11/10/25 | Pilkington v Glossop North End | 2-0 | | | | | | |
| Sat 18/10/25 | Longridge Town v Glossop North End | 2-1 | | | | |  | |
| Tue 21/10/25 | Ramsbottom United v Glossop North End | 1-0 | | | | | | |
| Sat 08/11/25 | Stockport Town v Glossop North End * | 1-2 | | | | | | |
| Sat 29/11/25 | Euxton Villa v Glossop North End * | 3-2 | | | | | | |
| Sat 20/12/25 | Glossop North End v FC Isle of Man * | 2-3 | | | | | | |
| Fri 26/12/25 | Irlam v Glossop North End | 0-1 | | | | | | |
| Tue 13/01/26 | New Mills v Glossop North End (CUP) | 0-0 | | | | | | |
| Sat 17/01/26 | Glossop North End v Ramsbottom United | 1-2 | | | | | | |
| Sat 24/01/26 | Glossop North End v Padiham | 3-1 | | | | | | |
