| Tue 03/08/21 | Cammell Laird 1907 v Ellesmere Rangers * | 0-1 | | | | | |
| Sat 14/08/21 | Stafford Town v Cammell Laird 1907 * | 2-0 | | | | | |
| Tue 17/08/21 | Cammell Laird 1907 v St Martins * | 4-1 | | | | | |
| Sat 25/09/21 | Cammell Laird 1907 v Rocester * | 2-1 | | | | | |
| Sat 09/10/21 | Cheadle Town v Cammell Laird 1907 * | 1-1 | | | | | |
| Tue 12/10/21 | Cammell Laird 1907 v Stockport Town | 2-1 | | | | | |
| Tue 19/10/21 | Cammell Laird 1907 v Capenhurst Villa | 1-0 | | | | | |
| Sat 23/10/21 | Maine Road v Cammell Laird 1907 | 5-0 | | | | |  |
| Sat 30/10/21 | Cammell Laird 1907 v Stockport Town | 0-4 | | | | | |
| Sat 06/11/21 | Cammell Laird 1907 v New Mills | 3-1 | | | | | |
| Tue 09/11/21 | Cammell Laird 1907 v Abbey Hey | 0-4 | | | | | |
| Sat 13/11/21 | Barnton v Cammell Laird 1907 | 1-2 | | | | | |
| Sat 20/11/21 | Cammell Laird 1907 v Wythenshawe Amateurs | 1-1 | | |  | | |
| Sat 04/12/21 | Cammell Laird 1907 v Barnton | 1-1 | | | | | |
| Sat 18/12/21 | Abbey Hey v Cammell Laird 1907 | 2-1 | | | | | |
| Mon 27/12/21 | West Didsbury & Chorlton v Cammell Laird 1907 | 5-0 | | | | | |
| Tue 04/01/22 | Cammell Laird 1907 v Cheadle Town | 1-4 | | | | | |
| Sat 08/01/22 | St Martins v Cammell Laird 1907 | 0-6 | | | | | |
| Tue 11/01/22 | Rocester v Cammell Laird 1907 | 1-5 | | | | | |
| Sat 15/01/22 | Abbey Hulton United v Cammell Laird 1907 | 0-1 | | | | | |
| Tue 18/01/22 | Cammell Laird 1907 v Tranmere Rovers | 1-4 | | | | | |
| Sat 22/01/22 | Cammell Laird 1907 v Stafford Town | 2-1 | | | | | |
| Sat 29/01/22 | Cheadle Heath Nomads v Cammell Laird 1907 | 6-0 | | | | | |
| Sat 05/02/22 | Cammell Laird 1907 v Maine Road | 2-7 | | | | | |
| Sat 12/02/22 | FC Isle of Man v Cammell Laird 1907 * | 0-0 | | | | | |
| Sat 19/02/22 | Stockport Town v Cammell Laird 1907 * | 4-0 | | | | | |
| Sat 26/02/22 | Cammell Laird 1907 v Alsager Town | 5-1 | | | | | |
| Sat 05/03/22 | Cammell Laird 1907 v Brocton | 0-0 | | | | | |
| Wed 09/03/22 | Cammell Laird 1907 v Ellesmere Port Town * | 3-1 | | | | | |
| Sat 12/03/22 | New Mills v Cammell Laird 1907 * | 4-2 | | | | | |
| Tue 15/03/22 | Cammell Laird 1907 v Stockport Town * | 3-2 | | | | | |
| Sat 19/03/22 | Cammell Laird 1907 v Sandbach United | 0-1 | | | | | |
| Sat 26/03/22 | Cammell Laird 1907 v Eccleshall | 1-2 | | | | | |
| Sat 02/04/22 | Ellesmere Rangers v Cammell Laird 1907 | 2-2 | | | | | |
| Tue 12/04/22 | Vauxhall Motors v Cammell Laird 1907 | 1-2 |  | | | | |
| Sat 23/04/22 | Cammell Laird 1907 v Heswall | 3-0 | | | | | |
| Tue 26/04/22 | Cammell Laird 1907 v Wythenshawe Amateurs | 3-2 | | | | | |
| Sat 30/04/22 | Cammell Laird 1907 v Barnton | 1-0 | | | | | |
| Mon 02/05/22 | Wythenshawe Amateurs v Cammell Laird 1907 | 2-4 | | | | | |
| Sat 07/05/22 | Cammell Laird 1907 v Ilkley Town | 2-2 | | | | | |
