| Sat 30/07/22 | South Liverpool v Daisy Hill * | 2-4 | | | | | |
| Wed 10/08/22 | South Liverpool v Chadderton * | 2-3 | | | | | |
| Sat 13/08/22 | South Liverpool v Euxton Villa * | 1-3 | | | | | |
| Sat 20/08/22 | Cleator Moor Celtic v South Liverpool | 1-8 | | | | |  |
| Mon 29/08/22 | Pilkington v South Liverpool | 3-1 | | | | | |
| Sat 24/09/22 | South Liverpool v Hallam * | 1-2 | | | | | |
| Sat 08/10/22 | South Liverpool v Holker Old Boys * | 1-1 | | | | | |
| Sat 15/10/22 | Vauxhall Motors v South Liverpool * | 1-1 | | | | | |
| Sat 22/10/22 | Nelson v South Liverpool * | 1-4 | | | | | |
| Sat 29/10/22 | South Liverpool v Holker Old Boys | 1-2 | | | | | |
| Wed 02/11/22 | South Liverpool v Skelmersdale United | 3-3 | | | | | |
| Sat 05/11/22 | South Liverpool v AFC Blackpool * | 5-1 | | | | | |
| Sat 12/11/22 | Atherton LR v South Liverpool * | 1-3 | | | | | |
| Sat 19/11/22 | Cammell Laird 1907 v South Liverpool * | 1-4 | | | | | |
| Wed 23/11/22 | South Liverpool v Atherton LR * | 2-3 | | |  | | |
| Sat 26/11/22 | South Liverpool v AFC Blackpool * | 2-2 | | | | | |
| Wed 30/11/22 | South Liverpool v Litherland REMYCA * | 2-3 | | | | | |
| Fri 02/12/22 | South Liverpool v Ashton Town | 2-1 |  | | | | |
| Wed 07/12/22 | Darwen FC v South Liverpool | 2-2 | | | | | |
| Wed 28/12/22 | South Liverpool v Runcorn Town | 5-0 | | | | | |
| Sat 07/01/23 | South Liverpool v Darwen FC | 1-4 | | | | | |
| Tue 17/01/23 | Steeton v South Liverpool | 1-1 | | | | | |
| Sat 21/01/23 | South Liverpool v Abbey Hulton United | 4-1 | | | | | |
| Sat 28/01/23 | South Liverpool v Nelson | 2-1 | | | | | |
| Sat 18/02/23 | South Liverpool v Bacup Borough * | 2-4 | | | | | |
| Sat 25/02/23 | South Liverpool v Abbey Hulton United * | 1-1 | | | | | |
| Wed 01/03/23 | South Liverpool v Bacup Borough * | 4-1 | | | | | |
| Sat 04/03/23 | Daisy Hill v South Liverpool * | 0-4 | | | | | |
| Tue 07/03/23 | AFC Blackpool v South Liverpool | 2-0 | | | | | |
| Wed 29/03/23 | South Liverpool v FC St Helens * | 1-2 | | | |  | |
