| Sat 30/07/22 | FC Isle of Man v Lower Breck | 0-1 | | | | | |
| Tue 23/08/22 | Padiham v FC Isle of Man * | 0-1 | | | | | |
| Sat 27/08/22 | Congleton Town v FC Isle of Man * | 5-1 | | | | | |
| Sat 03/09/22 | FC Isle of Man v Barnoldswick Town * | 3-3 | | | | | |
| Tue 13/09/22 | Bury AFC v FC Isle of Man | 4-0 | | | | | |
| Sat 17/09/22 | FC Isle of Man v Prestwich Heys * | 0-3 | | | | | |
| Tue 20/09/22 | Irlam v FC Isle of Man * | 3-1 | | | | | |
| Tue 25/10/22 | Wythenshawe Town v FC Isle of Man * | 2-2 |  | | | | |
| Sat 29/10/22 | FC Isle of Man v Congleton Town * | 3-2 | | | | | |
| Sat 05/11/22 | FC Isle of Man v Northwich Victoria * | 1-3 | | | | | |
| Sat 26/11/22 | FC Isle of Man v Charnock Richard * | 2-1 | | | | | |
| Sat 03/12/22 | Barnoldswick Town v FC Isle of Man * | 0-1 | | |  | | |
| Sat 10/12/22 | FC Isle of Man v Litherland REMYCA * | 2-3 | | | | | |
| Sat 17/12/22 | FC Isle of Man v AFC Liverpool * | 0-2 | | | | | |
| Wed 28/12/22 | Avro v FC Isle of Man | 0-1 | | | | | |
| Mon 02/01/23 | FC Isle of Man v Burscough | 3-4 | | | | | |
| Sat 07/01/23 | FC Isle of Man v Kendal Town | 1-3 | | | | | |
| Sat 21/01/23 | FC Isle of Man v Vauxhall Motors | 0-3 | | | | | |
| Sat 04/02/23 | Kendal Town v FC Isle of Man * | 3-2 | | | | | |
| Sat 11/02/23 | FC Isle of Man v Irlam * | 4-1 | | | |  |  |
| Sun 12/03/23 | Northwich Victoria v FC Isle of Man * | 1-1 | | | | | |
| Sat 18/03/23 | FC Isle of Man v Longridge Town * | 3-5 | | | | | |
| Sat 25/03/23 | FC Isle of Man v West Didsbury & Chorlton * | 2-2 | | | | | |
| Sat 08/04/23 | FC Isle of Man v Avro * | 1-0 | | | | | |
| Sat 22/04/23 | FC Isle of Man v Wythenshawe Town | 3-1 | | | | | |
