| Tue 03/08/21 | Cammell Laird 1907 v Ellesmere Rangers * | 0-1 | | | | | |
| Sat 07/08/21 | Brocton v Cammell Laird 1907 | 3-2 | | | | | |
| Sat 14/08/21 | Stafford Town v Cammell Laird 1907 | 2-0 | | | | |  |
| Sat 28/08/21 | Cammell Laird 1907 v Abbey Hulton United | 0-2 | | | | | |
| Sat 04/09/21 | Cammell Laird 1907 v FC Isle of Man * | 1-6 |  | | | | |
| Tue 07/09/21 | Cammell Laird 1907 v West Didsbury & Chorlton * | 0-5 | | | | | |
| Sat 11/09/21 | Brigg Town v Cammell Laird 1907 | 3-2 | | | | | |
| Sat 18/09/21 | Sandbach United v Cammell Laird 1907 | 3-3 | | | | | |
| Tue 21/09/21 | Cammell Laird 1907 v Shaftesbury Youth Club | 4-4 | | | | | |
| Sat 25/09/21 | Cammell Laird 1907 v Rocester | 2-1 | | | | | |
| Sat 09/10/21 | Cheadle Town v Cammell Laird 1907 * | 1-1 | | | | | |
| Tue 12/10/21 | Cammell Laird 1907 v Stockport Town | 2-1 | | | | | |
| Tue 19/10/21 | Cammell Laird 1907 v Capenhurst Villa | 1-0 | | | | | |
| Sat 23/10/21 | Maine Road v Cammell Laird 1907 * | 5-0 | | | | | |
| Sat 30/10/21 | Cammell Laird 1907 v Stockport Town * | 0-4 | | | | | |
| Sat 06/11/21 | Cammell Laird 1907 v New Mills | 3-1 | | | | | |
| Tue 09/11/21 | Cammell Laird 1907 v Abbey Hey | 0-4 | | | | | |
| Sat 13/11/21 | Barnton v Cammell Laird 1907 | 1-2 | | |  | | |
| Sat 20/11/21 | Cammell Laird 1907 v Wythenshawe Amateurs | 1-1 | | | | | |
| Sat 04/12/21 | Cammell Laird 1907 v Barnton | 1-1 | | | | | |
| Sat 18/12/21 | Abbey Hey v Cammell Laird 1907 | 2-1 | | | | | |
| Mon 27/12/21 | West Didsbury & Chorlton v Cammell Laird 1907 | 5-0 | | | | | |
| Tue 04/01/22 | Cammell Laird 1907 v Cheadle Town | 1-4 | | | | | |
| Sat 08/01/22 | St Martins v Cammell Laird 1907 * | 0-6 | | | | | |
| Tue 11/01/22 | Rocester v Cammell Laird 1907 | 1-5 | | | | | |
| Sat 15/01/22 | Abbey Hulton United v Cammell Laird 1907 | 0-1 | | | | | |
| Tue 18/01/22 | Cammell Laird 1907 v Tranmere Rovers | 1-4 | | | | | |
| Sat 05/02/22 | Cammell Laird 1907 v Maine Road | 2-7 | | | | | |
| Sat 30/04/22 | Cammell Laird 1907 v Barnton * | 1-0 | | | | | |
| Mon 02/05/22 | Wythenshawe Amateurs v Cammell Laird 1907 | 2-4 | | | | | |
| Sat 07/05/22 | Cammell Laird 1907 v Ilkley Town | 2-2 | | | | | |
| Tue 10/05/22 | Cammell Laird 1907 v Congleton Town * | 3-2 | | | | | |
| Sat 14/05/22 | Charnock Richard v Cammell Laird 1907 * | 5-0 | | | | | |
| Sat 21/05/22 | FC Isle of Man v Cammell Laird 1907 | 1-0 | | | | | |
