| Wed 04/08/21 | South Liverpool v Ashton Town | 4-2 | | | | | |
| Sat 07/08/21 | Steeton v South Liverpool | 3-3 |  | | | |  |
| Sat 14/08/21 | South Liverpool v Chadderton | 2-3 | | | | | |
| Sat 28/08/21 | South Liverpool v Ilkley Town | 2-3 | | | | | |
| Mon 30/08/21 | St Helens Town v South Liverpool | 1-3 | | | | | |
| Sat 04/09/21 | Cleator Moor Celtic v South Liverpool | 0-2 | | | | | |
| Sat 11/09/21 | South Liverpool v Atherton LR | 1-1 | | | | | |
| Fri 15/10/21 | South Liverpool v Pilkington | 5-1 | | | | | |
| Sat 23/10/21 | Thornaby v South Liverpool | 4-0 | | |  | | |
| Tue 26/10/21 | Golcar United v South Liverpool | 4-0 | | | | | |
| Sat 06/11/21 | South Liverpool v Garstang | 3-1 | | | | | |
| Tue 09/11/21 | Bacup Borough v South Liverpool | 1-1 | | | | | |
| Tue 16/11/21 | Bury AFC v South Liverpool | 5-0 | | | | | |
| Sat 20/11/21 | South Liverpool v Steeton | - | | | | | |
| Sat 27/11/21 | South Liverpool v Campion | 1-3 | | | | | |
| Sat 04/12/21 | Pilkington v South Liverpool | 2-2 | | | | | |
| Sat 11/12/21 | South Liverpool v Daisy Hill | 1-0 | | | | | |
| Sat 18/12/21 | AFC Blackpool v South Liverpool | 2-1 | | | | | |
| Sat 08/01/22 | South Liverpool v Steeton | 1-3 | | | | | |
| Sat 15/01/22 | Garstang v South Liverpool | 2-2 | | | | | |
| Sat 22/01/22 | South Liverpool v Bury AFC | 0-2 | | | | | |
| Wed 26/01/22 | AFC Darwen v South Liverpool | 2-3 | | | | | |
| Sat 29/01/22 | Ashton Town v South Liverpool | 1-3 | | | | | |
| Fri 04/02/22 | South Liverpool v St Helens Town | 4-1 | | | | | |
| Sat 12/02/22 | Atherton LR v South Liverpool | 3-2 | | | | | |
| Sat 26/02/22 | South Liverpool v Bacup Borough | 2-0 | | | | | |
| Sat 12/03/22 | South Liverpool v Golcar United | 1-0 | | | | | |
| Wed 16/03/22 | South Liverpool v Litherland REMYCA | 2-2 | | | | | |
| Sat 19/03/22 | Nelson v South Liverpool | 0-0 | | | | | |
| Sat 26/03/22 | South Liverpool v Cleator Moor Celtic * | 0-2 | | | | | |
| Sat 02/04/22 | South Liverpool v AFC Darwen | 0-1 | | | | | |
| Sat 09/04/22 | Ashton Town v South Liverpool | 1-1 | | | | | |
| Wed 13/04/22 | Barnton v South Liverpool | 4-4 | | | | | |
