| Sat 31/07/21 | Stafford Town v Ellesmere Rangers * | 3-4 | | | | | |
| Tue 17/08/21 | Ellesmere Rangers v Eccleshall * | 3-0 | | | | | |
| Sat 21/08/21 | Ellesmere Rangers v Brocton | 0-3 | | | | | |
| Sat 04/09/21 | Ellesmere Rangers v New Mills | 1-3 | | | | | |
| Sat 11/09/21 | Ellesmere Rangers v Wythenshawe Amateurs | 1-1 | | | | | |
| Sat 25/09/21 | Wolverhampton Casuals v Ellesmere Rangers | 4-1 | | | | | |
| Tue 28/09/21 | Ellesmere Rangers v Haughmond | 3-4 | | | | | |
| Sat 02/10/21 | Ellesmere Rangers v FC Isle of Man * | 2-3 | | | | | |
| Sat 09/10/21 | Ellesmere Rangers v Cheadle Heath Nomads * | 3-3 | | | | | |
| Sat 16/10/21 | West Didsbury & Chorlton v Ellesmere Rangers | 1-1 | | | | | |
| Sat 23/10/21 | Ellesmere Rangers v Alsager Town | 3-3 | | | | |  |
| Sat 30/10/21 | Ellesmere Rangers v Abbey Hulton United | 4-2 | | | | | |
| Sat 06/11/21 | Cheadle Town v Ellesmere Rangers | 7-1 | | | | | |
| Sat 13/11/21 | Ellesmere Rangers v Abbey Hey * | 1-2 | | | | | |
| Sat 20/11/21 | Eccleshall v Ellesmere Rangers * | 2-3 | | | | | |
| Sat 04/12/21 | Wythenshawe Amateurs v Ellesmere Rangers | - | | | | | |
| Sat 11/12/21 | Alsager Town v Ellesmere Rangers | 2-2 | | | | | |
| Mon 27/12/21 | Ellesmere Rangers v St Martins * | 7-0 | | | | | |
| Sat 15/01/22 | FC Isle of Man v Ellesmere Rangers | 3-0 | | | | | |
| Sat 29/01/22 | Ellesmere Rangers v Cheadle Town * | 1-8 | | |  | | |
| Sat 05/02/22 | Sandbach United v Ellesmere Rangers | 4-1 | | | | | |
| Tue 08/02/22 | Rocester v Ellesmere Rangers | 2-2 | | | | | |
| Sat 12/02/22 | Ellesmere Rangers v Stockport Town | 1-3 | | | | | |
| Tue 22/02/22 | St Martins v Ellesmere Rangers | 0-5 | | | | | |
| Sat 12/03/22 | Ellesmere Rangers v Stafford Town | 1-0 | | | | | |
| Thu 31/03/22 | Ellesmere Rangers v Maine Road * | 3-5 | | | | | |
| Sat 02/04/22 | Ellesmere Rangers v Cammell Laird 1907 | 2-2 | | | | | |
| Tue 05/04/22 | Ellesmere Rangers v Sandbach United | 2-3 | | | | | |
