| Sat 30/07/22 | Pilkington v Ashton Town * | 5-1 | | | | | |
| Wed 03/08/22 | Darwen FC v Pilkington * | 0-2 | | | | | |
| Wed 10/08/22 | Pilkington v Daisy Hill * | 4-0 | | | | | |
| Sat 13/08/22 | Atherton LR v Pilkington * | 1-6 | | | | | |
| Sat 20/08/22 | Chadderton v Pilkington * | 0-2 | | | | | |
| Mon 29/08/22 | Pilkington v South Liverpool * | 3-1 |  | | | | |
| Sat 03/09/22 | Runcorn Town v Pilkington | 2-4 | | | | | |
| Sat 17/09/22 | Pilkington v Holker Old Boys | 3-2 | | | | | |
| Sat 01/10/22 | AFC Blackpool v Pilkington | 0-2 | | | | | |
| Sat 08/10/22 | Daisy Hill v Pilkington | 2-3 | | |  | | |
| Sat 15/10/22 | Pilkington v West Didsbury & Chorlton | 3-0 | | | | | |
| Sat 22/10/22 | Thornaby v Pilkington | 2-2 | | | | | |
| Sat 29/10/22 | Steeton v Pilkington | 1-1 | | | | | |
| Wed 02/11/22 | Pilkington v Euxton Villa | 0-1 | | | | | |
| Sat 05/11/22 | Nelson v Pilkington | 0-1 | | | | | |
| Sat 12/11/22 | Pilkington v Cleator Moor Celtic | 4-0 | | | | | |
| Sat 19/11/22 | Pilkington v Irlam | 1-1 | | | | | |
| Tue 22/11/22 | Marine v Pilkington | 4-0 | | | | | |
| Sat 26/11/22 | Pilkington v Ashton Town | 4-2 | | | | | |
| Sat 03/12/22 | Pilkington v Runcorn Town | 4-1 | | | | | |
| Wed 21/12/22 | Pilkington v Bacup Borough | 2-1 | | | | | |
| Mon 26/12/22 | Pilkington v FC St Helens | 1-1 | | | | | |
| Sat 07/01/23 | Pilkington v AFC Blackpool * | 5-1 | | | | | |
| Sat 21/01/23 | Pilkington v Avro | 2-4 | | | | | |
| Tue 24/01/23 | Euxton Villa v Pilkington | 0-1 | | | | | |
| Sat 28/01/23 | Pilkington v Ilkley Town | 2-3 | | | | |  |
| Mon 30/01/23 | Daisy Hill v Pilkington | 0-2 | | | | | |
| Sat 04/02/23 | Pilkington v Steeton | 1-2 | | | | | |
| Tue 07/02/23 | Ashton Town v Pilkington | 0-0 | | | | | |
| Fri 10/02/23 | South Liverpool v Pilkington | 1-2 | | | | | |
| Sat 18/02/23 | Pilkington v Chadderton | 0-0 | |  | | | |
| Tue 21/02/23 | Ilkley Town v Pilkington | 2-3 | | | | | |
| Sat 04/03/23 | Holker Old Boys v Pilkington | 0-1 | | | | | |
| Sat 11/03/23 | Pilkington v Atherton LR | 2-2 | | | | | |
| Sat 18/03/23 | Pilkington v Nelson | 2-0 | | | | | |
