| Sat 30/07/22 | Prestwich Heys v Burscough | 3-0 | | | | | |
| Tue 02/08/22 | West Didsbury & Chorlton v Prestwich Heys | 2-1 | | | | |  |
| Sat 06/08/22 | Prestwich Heys v Litherland REMYCA | 1-1 | | | | | |
| Wed 10/08/22 | Litherland REMYCA v Prestwich Heys | 3-4 | | |  | | |
| Sat 13/08/22 | Prestwich Heys v Charnock Richard | 4-1 | | | | | |
| Sat 20/08/22 | Prestwich Heys v Stocksbridge Park Steels | 2-2 | | | | | |
| Mon 29/08/22 | Barnoldswick Town v Prestwich Heys | 3-5 | | | | | |
| Sat 03/09/22 | Prestwich Heys v AFC Liverpool * | 0-2 | | | | | |
| Tue 06/09/22 | Kendal Town v Prestwich Heys | 2-1 | | | | | |
| Sat 17/09/22 | FC Isle of Man v Prestwich Heys | 0-3 | | | | | |
| Sat 01/10/22 | Prestwich Heys v Avro | 1-0 | | | | | |
| Sat 08/10/22 | Ashton Athletic v Prestwich Heys | 0-3 | | | | | |
| Tue 11/10/22 | Prestwich Heys v Padiham | 4-0 | | | | | |
| Sat 22/10/22 | Winterton Rangers v Prestwich Heys | 1-2 | | | | | |
| Tue 25/10/22 | Congleton Town v Prestwich Heys | 1-0 | |  | | | |
| Sat 29/10/22 | Wythenshawe Town v Prestwich Heys | 3-1 | | | | | |
| Sat 12/11/22 | Prestwich Heys v Whitley Bay | 1-1 | | | | | |
| Tue 15/11/22 | Vauxhall Motors v Prestwich Heys | 0-1 | | | | | |
| Sat 19/11/22 | Prestwich Heys v Litherland REMYCA | 1-0 | | | | | |
| Sat 26/11/22 | Burscough v Prestwich Heys | 3-1 | | | |  | |
| Tue 24/01/23 | Prestwich Heys v Kendal Town | 1-1 | | | | | |
| Sat 28/01/23 | Northwich Victoria v Prestwich Heys | 1-0 | | | | | |
| Tue 31/01/23 | Prestwich Heys v Longridge Town | 2-0 |  | | | | |
| Sat 04/02/23 | Prestwich Heys v Vauxhall Motors | 1-0 | | | | | |
| Sat 25/02/23 | Prestwich Heys v FC Isle of Man | 1-0 | | | | | |
| Tue 28/02/23 | Irlam v Prestwich Heys | 0-1 | | | | | |
| Sat 04/03/23 | AFC Liverpool v Prestwich Heys | 5-1 | | | | | |
| Sat 11/03/23 | Avro v Prestwich Heys * | 1-2 | | | | | |
