| Sat 25/09/21 | South Liverpool v Dronfield Town | 4-1 | | | | | |
| Sat 02/10/21 | Campion v South Liverpool | 6-1 | | | | | |
| Fri 15/10/21 | South Liverpool v Pilkington | 5-1 |  | | | | |
| Sat 23/10/21 | Thornaby v South Liverpool | 4-0 | | | | | |
| Sat 06/11/21 | South Liverpool v Garstang | 3-1 | | | | | |
| Tue 09/11/21 | Bacup Borough v South Liverpool | 1-1 | | | | | |
| Tue 16/11/21 | Bury AFC v South Liverpool | 5-0 | | | | | |
| Sat 20/11/21 | South Liverpool v Steeton | - | | | | | |
| Sat 27/11/21 | South Liverpool v Campion | 1-3 | | | | | |
| Sat 04/12/21 | Pilkington v South Liverpool | 2-2 | | | | | |
| Sat 11/12/21 | South Liverpool v Daisy Hill | 1-0 | | | | | |
| Sat 18/12/21 | AFC Blackpool v South Liverpool | 2-1 | | |  | | |
| Sat 15/01/22 | Garstang v South Liverpool | 2-2 | | | | | |
| Sat 22/01/22 | South Liverpool v Bury AFC | 0-2 | | | | | |
| Wed 26/01/22 | AFC Darwen v South Liverpool | 2-3 | | | | |  |
| Sat 29/01/22 | Ashton Town v South Liverpool | 1-3 | | | | | |
| Fri 04/02/22 | South Liverpool v St Helens Town | 4-1 | | | | | |
| Sat 12/02/22 | Atherton LR v South Liverpool | 3-2 | | | | | |
| Sat 26/02/22 | South Liverpool v Bacup Borough | 2-0 | | | | | |
| Tue 01/03/22 | Chadderton v South Liverpool | 1-0 | | | | | |
| Sat 12/03/22 | South Liverpool v Golcar United | 1-0 | | | | | |
| Wed 16/03/22 | South Liverpool v Litherland REMYCA | 2-2 | | | | | |
| Sat 19/03/22 | Nelson v South Liverpool | 0-0 | | | | | |
| Tue 22/03/22 | Holker Old Boys v South Liverpool * | 0-0 | | | | | |
| Sat 26/03/22 | South Liverpool v Cleator Moor Celtic | 0-2 | | | | | |
| Sat 02/04/22 | South Liverpool v AFC Darwen | 0-1 | | | | | |
| Sat 09/04/22 | Ashton Town v South Liverpool | 1-1 | | | | | |
