| Sat 30/07/22 | FC Isle of Man v Lower Breck | 0-1 | | | | | |
| Thu 04/08/22 | Lower Breck v Vauxhall Motors | 1-2 | | | | | |
| Sat 06/08/22 | Lower Breck v Penistone Church * | 0-2 | | | | | |
| Mon 29/08/22 | Lower Breck v Wythenshawe Town | - | | | | | |
| Thu 08/09/22 | Lower Breck v Bury AFC * | 2-0 | | | | | |
| Wed 14/09/22 | Litherland REMYCA v Lower Breck * | 1-0 | | | | | |
| Tue 04/10/22 | West Didsbury & Chorlton v Lower Breck * | 1-4 | | | | | |
| Sat 08/10/22 | Lower Breck v Northwich Victoria * | 1-3 | | | | | |
| Sat 15/10/22 | Litherland REMYCA v Lower Breck * | 0-4 | | | | | |
| Thu 20/10/22 | Lower Breck v AFC Liverpool | 2-0 | | |  | | |
| Sat 22/10/22 | Congleton Town v Lower Breck | 2-1 | | | | | |
| Sat 29/10/22 | Lower Breck v Barnoldswick Town | 1-0 | | | | |  |
| Thu 03/11/22 | Lower Breck v Wythenshawe Town | 4-0 |  | | | | |
| Sat 05/11/22 | Burscough v Lower Breck | 0-0 | | | | | |
| Sat 12/11/22 | Lower Breck v Winsford United | 1-2 | | | | | |
| Wed 16/11/22 | AFC Liverpool v Lower Breck | 0-0 | | | | | |
| Sat 19/11/22 | Lower Breck v Wythenshawe Amateurs * | 4-0 | | | | | |
| Sat 26/11/22 | Bury AFC v Lower Breck | 3-1 | | | | | |
| Wed 30/11/22 | AFC Liverpool v Lower Breck | 4-3 | | | | | |
| Sat 14/01/23 | Lower Breck v Squires Gate | 3-1 | | | | | |
| Thu 26/01/23 | Lower Breck v Congleton Town | 0-1 | | | | | |
| Sat 28/01/23 | Barnoldswick Town v Lower Breck | 3-3 | | | | | |
| Tue 31/01/23 | Padiham v Lower Breck | 3-1 | | | | | |
| Sat 04/02/23 | Lower Breck v Longridge Town | 2-3 | | | | | |
| Sat 11/02/23 | Kendal Town v Lower Breck | 1-1 | | | | | |
| Sat 25/02/23 | Ashton Athletic v Lower Breck | 0-1 | | | | | |
| Sat 04/03/23 | Vauxhall Motors v Lower Breck | 6-1 | | | | | |
| Sat 11/03/23 | Lower Breck v Charnock Richard * | 3-0 | | | | | |
| Thu 16/03/23 | Lower Breck v Congleton Town * | 1-2 | | | | | |
| Sat 18/03/23 | Irlam v Lower Breck * | 0-0 | | | | | |
