| Sat 30/07/22 | Squires Gate v AFC Liverpool * | 1-4 | | | | | |
| Wed 10/08/22 | Squires Gate v Irlam | 3-3 |  | | | | |
| Sat 13/08/22 | Litherland REMYCA v Squires Gate | 0-2 | | | | | |
| Wed 17/08/22 | Squires Gate v Padiham | 0-2 | | | | | |
| Sat 27/08/22 | Squires Gate v Easington Colliery | 2-1 | | | | | |
| Tue 30/08/22 | Bury AFC v Squires Gate | 2-1 | | | | | |
| Sat 03/09/22 | Squires Gate v Wythenshawe Town | 1-3 | | | | | |
| Wed 07/09/22 | Squires Gate v Ashton Athletic | 2-1 | | | | | |
| Wed 14/09/22 | Squires Gate v Barnoldswick Town | 3-0 | | | | | |
| Sat 17/09/22 | Vauxhall Motors v Squires Gate | 3-1 | | | | | |
| Tue 20/09/22 | Prestwich Heys v Squires Gate | 3-1 | | | | | |
| Sat 24/09/22 | West Allotment Celtic v Squires Gate | 2-2 | | | | | |
| Sat 08/10/22 | Wythenshawe Town v Squires Gate | 6-0 | | | | | |
| Sat 15/10/22 | Cleator Moor Celtic v Squires Gate | 1-3 | | | | | |
| Sat 22/10/22 | Squires Gate v Cammell Laird 1907 | 2-1 | | |  | | |
| Wed 26/10/22 | Squires Gate v Avro | 2-1 | | | | | |
| Sat 29/10/22 | Irlam v Squires Gate | 0-3 | | | | | |
| Sat 05/11/22 | Squires Gate v Winsford United | 2-3 | | | | | |
| Wed 09/11/22 | Squires Gate v Charnock Richard * | 3-2 | | | | | |
| Sat 12/11/22 | Emley v Squires Gate | 1-1 | | | | | |
| Sat 26/11/22 | West Didsbury & Chorlton v Squires Gate * | 1-1 | | | | | |
| Wed 30/11/22 | Northwich Victoria v Squires Gate | 5-1 | | | | | |
| Sat 03/12/22 | Holker Old Boys v Squires Gate | 4-2 | | | | | |
| Tue 06/12/22 | Congleton Town v Squires Gate | 2-1 | | | | | |
| Tue 20/12/22 | Squires Gate v Bury AFC | 0-1 | | | | | |
| Mon 26/12/22 | Squires Gate v Burscough | 1-3 | | | | | |
| Wed 04/01/23 | Squires Gate v Kendal Town | 2-2 | | | | | |
| Sat 14/01/23 | Lower Breck v Squires Gate | 3-1 | | | | | |
| Tue 24/01/23 | Wythenshawe Town v Squires Gate | 1-3 | | | | | |
| Sat 28/01/23 | FC Isle of Man v Squires Gate | 1-4 | | | | | |
| Wed 01/02/23 | Squires Gate v Congleton Town | 1-1 | | | | | |
| Wed 15/02/23 | Barnoldswick Town v Squires Gate * | 0-2 | | | | | |
| Sat 18/02/23 | FC St Helens v Squires Gate | 2-0 | | | | | |
| Sat 04/03/23 | Squires Gate v West Didsbury & Chorlton * | 1-3 | | | | | |
| Fri 10/03/23 | AFC Liverpool v Squires Gate | 2-0 | | | | | |
| Tue 21/03/23 | Longridge Town v Squires Gate * | 3-0 | | | | | |
