| Tue 03/08/21 | Cammell Laird 1907 v Ellesmere Rangers | 0-1 | | | | | |
| Sat 07/08/21 | Ellesmere Rangers v Sandbach United | 1-1 | | | | | |
| Sat 14/08/21 | Barnton v Ellesmere Rangers | 2-3 | | | | | |
| Tue 17/08/21 | Ellesmere Rangers v Eccleshall | 3-0 | | |  | | |
| Sat 28/08/21 | Stockport Town v Ellesmere Rangers | 1-4 | | | | | |
| Sat 04/09/21 | Ellesmere Rangers v New Mills | 1-3 | | | | | |
| Sat 18/09/21 | Maine Road v Ellesmere Rangers | 3-2 | | | | | |
| Sat 25/09/21 | Wolverhampton Casuals v Ellesmere Rangers | 4-1 | | | | | |
| Tue 28/09/21 | Ellesmere Rangers v Haughmond | 3-4 | | | | | |
| Sat 02/10/21 | Ellesmere Rangers v FC Isle of Man | 2-3 | | | | | |
| Sat 06/11/21 | Cheadle Town v Ellesmere Rangers * | 7-1 | | | | | |
| Tue 09/11/21 | Ellesmere Rangers v Rocester | 2-3 | | | | | |
| Sat 13/11/21 | Ellesmere Rangers v Abbey Hey | 1-2 | | | | | |
| Sat 20/11/21 | Eccleshall v Ellesmere Rangers | 2-3 | | | | |  |
| Sat 27/11/21 | Ellesmere Rangers v Barnton | 0-2 | | | | | |
| Tue 14/12/21 | Wythenshawe Amateurs v Ellesmere Rangers | 5-0 | | | | | |
| Sat 18/12/21 | Ellesmere Rangers v West Didsbury & Chorlton | 1-0 | | | | | |
| Mon 27/12/21 | Ellesmere Rangers v St Martins | 7-0 | | | | | |
| Sat 15/01/22 | FC Isle of Man v Ellesmere Rangers | 3-0 | | | | | |
| Sat 22/01/22 | Brocton v Ellesmere Rangers | 2-1 | | | | | |
| Sat 29/01/22 | Ellesmere Rangers v Cheadle Town | 1-8 | | | | | |
| Tue 08/02/22 | Rocester v Ellesmere Rangers | 2-2 | | | | | |
| Sat 26/02/22 | Abbey Hulton United v Ellesmere Rangers | 1-0 | | | | | |
| Wed 09/03/22 | New Mills v Ellesmere Rangers | 3-1 | | | | | |
| Sat 12/03/22 | Ellesmere Rangers v Stafford Town | 1-0 | | | | | |
| Sat 19/03/22 | Cheadle Heath Nomads v Ellesmere Rangers * | 1-1 | | | | | |
| Sat 26/03/22 | Abbey Hey v Ellesmere Rangers | 2-1 | | | | | |
| Sat 02/04/22 | Ellesmere Rangers v Cammell Laird 1907 | 2-2 | | | | | |
| Tue 05/04/22 | Ellesmere Rangers v Sandbach United * | 2-3 | | | | | |
