| Sat 31/07/21 | Stafford Town v Ellesmere Rangers | 3-4 | | | | | |
| Tue 03/08/21 | Cammell Laird 1907 v Ellesmere Rangers | 0-1 | | | | |  |
| Sat 14/08/21 | Barnton v Ellesmere Rangers | 2-3 | | | | | |
| Tue 17/08/21 | Ellesmere Rangers v Eccleshall | 3-0 | | | | | |
| Sat 21/08/21 | Ellesmere Rangers v Brocton | 0-3 | | | | | |
| Sat 28/08/21 | Stockport Town v Ellesmere Rangers | 1-4 | | | | | |
| Mon 30/08/21 | St Martins v Ellesmere Rangers | 0-8 | | | | | |
| Sat 11/09/21 | Ellesmere Rangers v Wythenshawe Amateurs | 1-1 | | | | | |
| Sat 25/09/21 | Wolverhampton Casuals v Ellesmere Rangers | 4-1 | | | | | |
| Tue 28/09/21 | Ellesmere Rangers v Haughmond | 3-4 | | | | | |
| Sat 09/10/21 | Ellesmere Rangers v Cheadle Heath Nomads | 3-3 | | | | | |
| Sat 16/10/21 | West Didsbury & Chorlton v Ellesmere Rangers | 1-1 | | |  | | |
| Sat 30/10/21 | Ellesmere Rangers v Abbey Hulton United * | 4-2 | | | | | |
| Sat 06/11/21 | Cheadle Town v Ellesmere Rangers | 7-1 | | | | | |
| Tue 09/11/21 | Ellesmere Rangers v Rocester | 2-3 | | | | | |
| Sat 13/11/21 | Ellesmere Rangers v Abbey Hey | 1-2 | | | | | |
| Sat 20/11/21 | Eccleshall v Ellesmere Rangers | 2-3 | | | | | |
| Sat 27/11/21 | Ellesmere Rangers v Barnton | 0-2 | | | | | |
| Sat 04/12/21 | Wythenshawe Amateurs v Ellesmere Rangers | - | | | | | |
| Sat 11/12/21 | Alsager Town v Ellesmere Rangers | 2-2 | | | | | |
| Tue 14/12/21 | Wythenshawe Amateurs v Ellesmere Rangers | 5-0 | | | | | |
| Sat 18/12/21 | Ellesmere Rangers v West Didsbury & Chorlton | 1-0 |  | | | | |
| Sat 15/01/22 | FC Isle of Man v Ellesmere Rangers | 3-0 | | | | | |
| Sat 22/01/22 | Brocton v Ellesmere Rangers | 2-1 | | | | | |
| Sat 05/02/22 | Sandbach United v Ellesmere Rangers | 4-1 | | | | | |
| Tue 08/02/22 | Rocester v Ellesmere Rangers | 2-2 | | | | | |
| Tue 22/02/22 | St Martins v Ellesmere Rangers | 0-5 | | | | | |
| Wed 09/03/22 | New Mills v Ellesmere Rangers | 3-1 | | | | | |
| Sat 19/03/22 | Cheadle Heath Nomads v Ellesmere Rangers | 1-1 | | | | | |
| Sat 26/03/22 | Abbey Hey v Ellesmere Rangers | 2-1 | | | | | |
| Thu 31/03/22 | Ellesmere Rangers v Maine Road | 3-5 | | | | | |
| Sat 02/04/22 | Ellesmere Rangers v Cammell Laird 1907 | 2-2 | | | | | |
| Tue 05/04/22 | Ellesmere Rangers v Sandbach United | 2-3 | | | | | |
