| Sat 14/08/21 | Cleator Moor Celtic v St Helens Town | 10-0 | | | | | |
| Wed 18/08/21 | Campion v Cleator Moor Celtic | 3-1 |  | | | | |
| Sat 21/08/21 | Cleator Moor Celtic v Bury AFC | 2-2 | | | | | |
| Mon 30/08/21 | Cleator Moor Celtic v Holker Old Boys | 1-2 | | |  | | |
| Sat 04/09/21 | Cleator Moor Celtic v South Liverpool | 0-2 | | | | |  |
| Sat 11/09/21 | Sunderland West End v Cleator Moor Celtic | 2-3 | | | | | |
| Sat 18/09/21 | Steeton v Cleator Moor Celtic | 3-0 | | | | | |
| Sat 09/10/21 | Cleator Moor Celtic v Daisy Hill | 2-3 | | | | | |
| Wed 13/10/21 | Cleator Moor Celtic v Penrith | 6-5 | | | |  | |
| Sat 16/10/21 | Cleator Moor Celtic v Nelson | 5-3 | | | | | |
| Tue 19/10/21 | Golcar United v Cleator Moor Celtic | 3-0 | | | | | |
| Wed 27/10/21 | Garstang v Cleator Moor Celtic | 1-3 | | | | | |
| Sat 30/10/21 | Cleator Moor Celtic v Atherton LR | 3-1 | | | | | |
| Wed 03/11/21 | AFC Darwen v Cleator Moor Celtic | 4-2 | | | | | |
| Sat 06/11/21 | Chadderton v Cleator Moor Celtic | 1-4 | | | | | |
| Tue 09/11/21 | Cleator Moor Celtic v Pilkington | 3-0 | | | | | |
| Sat 13/11/21 | Cleator Moor Celtic v Ashton Town | 2-1 | | | | | |
| Tue 16/11/21 | Cleator Moor Celtic v Keswick | 7-0 | | | | | |
| Sat 20/11/21 | Ashton Town v Cleator Moor Celtic | 3-2 | | | | | |
| Sun 28/11/21 | Bury AFC v Cleator Moor Celtic | 5-1 | | | | | |
| Sat 04/12/21 | Cleator Moor Celtic v Ilkley Town | 3-0 | | | | | |
| Sat 18/12/21 | Cleator Moor Celtic v Golcar United | 2-3 | | | | | |
| Sat 08/01/22 | St Helens Town v Cleator Moor Celtic | 4-5 | | | | | |
| Tue 11/01/22 | Holker Old Boys v Cleator Moor Celtic | 2-0 | | | | | |
| Sat 15/01/22 | Cleator Moor Celtic v AFC Blackpool | 1-2 | | | | | |
| Sat 22/01/22 | Pilkington v Cleator Moor Celtic | - | | | | | |
| Sat 29/01/22 | Daisy Hill v Cleator Moor Celtic | 2-3 | | | | | |
| Sat 05/02/22 | Cleator Moor Celtic v Garstang | 2-1 | | | | | |
| Wed 09/02/22 | Cleator Moor Celtic v Carlisle United | 1-1 | | | | | |
| Sat 12/02/22 | Cleator Moor Celtic v Chadderton | 2-0 | | | | | |
| Tue 22/02/22 | Holker Old Boys v Cleator Moor Celtic | 3-0 | | | | | |
| Sat 26/02/22 | Pilkington v Cleator Moor Celtic | 4-2 | | | | | |
| Sat 05/03/22 | Atherton LR v Cleator Moor Celtic | 0-1 | | | | | |
| Sat 12/03/22 | Cleator Moor Celtic v Steeton | 5-1 | | | | | |
| Tue 15/03/22 | Nelson v Cleator Moor Celtic | 2-2 | | | | | |
| Sat 19/03/22 | Cleator Moor Celtic v AFC Darwen | 0-2 | | | | | |
| Sat 02/04/22 | Cleator Moor Celtic v Campion | 7-1 | | | | | |
