| Wed 03/08/22 | Litherland REMYCA v FC Isle of Man | 1-2 |  | | | | |
| Sat 06/08/22 | Prestwich Heys v Litherland REMYCA * | 1-1 | | | | | |
| Wed 10/08/22 | Litherland REMYCA v Prestwich Heys | 3-4 | | | | | |
| Sat 13/08/22 | Litherland REMYCA v Squires Gate | 0-2 | | | | | |
| Wed 17/08/22 | Litherland REMYCA v Wythenshawe Town | 1-3 | | | | | |
| Sat 20/08/22 | Litherland REMYCA v Ashton Athletic | 2-0 | | | | |  |
| Tue 23/08/22 | Longridge Town v Litherland REMYCA | 0-1 | | | | | |
| Wed 14/09/22 | Litherland REMYCA v Lower Breck | 1-0 | | | | | |
| Sat 17/09/22 | Barnoldswick Town v Litherland REMYCA | 3-2 | | | | | |
| Wed 21/09/22 | AFC Liverpool v Litherland REMYCA | 1-0 | | | | | |
| Sat 24/09/22 | Litherland REMYCA v Charnock Richard | 3-2 | | | | | |
| Wed 28/09/22 | Northwich Victoria v Litherland REMYCA | 2-2 | | |  | | |
| Sat 01/10/22 | Litherland REMYCA v Kendal Town | 2-1 | | | | | |
| Sat 08/10/22 | Litherland REMYCA v Irlam | 0-4 | | | | | |
| Sat 15/10/22 | Litherland REMYCA v Lower Breck | 0-4 | | | | | |
| Sat 29/10/22 | Litherland REMYCA v Charnock Richard | 3-4 | | | | | |
| Wed 02/11/22 | Avro v Litherland REMYCA | 1-0 | | | | | |
| Sat 05/11/22 | Congleton Town v Litherland REMYCA | 2-1 | | | | | |
| Sat 19/11/22 | Prestwich Heys v Litherland REMYCA | 1-0 | | | | | |
| Tue 22/11/22 | West Didsbury & Chorlton v Litherland REMYCA | 2-1 | | | | | |
| Wed 30/11/22 | South Liverpool v Litherland REMYCA | 2-3 | | | | | |
| Sat 10/12/22 | FC Isle of Man v Litherland REMYCA | 2-3 | | | | | |
| Sat 04/02/23 | Litherland REMYCA v Bury AFC * | 0-1 | | | | | |
| Sat 11/02/23 | Burscough v Litherland REMYCA | 2-3 | | | | | |
| Tue 14/02/23 | Runcorn Linnets v Litherland REMYCA | 2-1 | | | | | |
| Sat 18/02/23 | Wythenshawe Town v Litherland REMYCA | 3-0 | | | | | |
| Sat 25/02/23 | Squires Gate v Litherland REMYCA | 0-2 | | | | | |
| Sat 18/03/23 | Ashton Athletic v Litherland REMYCA * | 0-5 | | | | | |
| Sat 25/03/23 | Litherland REMYCA v Congleton Town | 1-0 | | | | | |
| Mon 10/04/23 | Winsford United v Litherland REMYCA * | 1-2 | | | | | |
