| Sat 07/08/21 | Eccleshall v Stockport Town | 0-2 | | | | | |
| Sat 14/08/21 | Sandbach United v Eccleshall | 2-1 | | | | | |
| Tue 17/08/21 | Ellesmere Rangers v Eccleshall | 3-0 | | | | | |
| Sat 21/08/21 | Eccleshall v Cammell Laird 1907 | 1-2 | | | | | |
| Fri 27/08/21 | Barnton v Eccleshall | 5-1 | | | | |  |
| Mon 30/08/21 | Eccleshall v Stafford Town | 0-1 | | |  | | |
| Sat 04/09/21 | Eccleshall v Cheadle Heath Nomads | 2-2 | | | | | |
| Tue 07/09/21 | St Martins v Eccleshall | 1-3 | | | | | |
| Sat 18/09/21 | New Mills v Eccleshall | 3-0 | | | | | |
| Tue 28/09/21 | Eccleshall v Wythenshawe Amateurs | 6-4 | | | | | |
| Sat 09/10/21 | Eccleshall v FC Isle of Man | 0-4 | | | | | |
| Sat 16/10/21 | Eccleshall v Maine Road | 0-4 | | | | | |
| Sat 23/10/21 | Eccleshall v Abbey Hulton United | 0-1 | | | | | |
| Sat 30/10/21 | Alsager Town v Eccleshall | 0-1 | | | | | |
| Sat 27/11/21 | Maine Road v Eccleshall * | 4-0 | | | | | |
| Sat 04/12/21 | Eccleshall v Rocester | 1-1 | | | | | |
| Sat 11/12/21 | Brocton v Eccleshall | 4-1 | | | | | |
| Sat 18/12/21 | Cheadle Heath Nomads v Eccleshall | 2-3 | | | | | |
| Sat 08/01/22 | Eccleshall v Alsager Town | 2-0 |  | | | | |
| Sat 22/01/22 | Eccleshall v St Martins | 6-0 | | | | | |
| Tue 01/02/22 | Eccleshall v Stoke City | 0-3 | | | | | |
| Sat 05/02/22 | Abbey Hulton United v Eccleshall | 1-3 | | | | | |
| Sun 13/02/22 | FC Isle of Man v Eccleshall | 1-0 | | | | | |
| Sat 26/02/22 | Eccleshall v Barnton | 2-0 | | | | | |
| Tue 01/03/22 | Eccleshall v West Didsbury & Chorlton | 0-5 | | | | | |
| Sat 05/03/22 | Stockport Town v Eccleshall | 0-0 | | | | | |
| Sat 12/03/22 | Cheadle Town v Eccleshall | 1-1 | | | | | |
| Tue 15/03/22 | Wythenshawe Amateurs v Eccleshall | 4-3 | | | | | |
| Sat 19/03/22 | Eccleshall v New Mills | 0-5 | | | | | |
| Sat 26/03/22 | Cammell Laird 1907 v Eccleshall | 1-2 | | | | | |
| Sat 02/04/22 | Eccleshall v Sandbach United | 0-0 | | | | | |
| Tue 05/04/22 | Stafford Town v Eccleshall | 2-0 | | | | | |
