Sat 31/07/21 | Macclesfield v Burscough | 1-0 | | | | | |
Tue 03/08/21 | Winsford United v Macclesfield | 4-4 | | | | | |
Sat 07/08/21 | Macclesfield v Burscough | 4-0 | | | | | |
Sat 28/08/21 | Barnoldswick Town v Macclesfield | 1-2 | | | | | |
Sat 04/09/21 | Ashton Athletic v Macclesfield | 1-1 | | | | | |
Sat 18/09/21 | Macclesfield v Litherland REMYCA * | 4-0 | | | | | |
Sat 02/10/21 | Macclesfield v Charnock Richard | 4-1 | | | | | |
Tue 05/10/21 | Macclesfield v Northwich Victoria | 2-1 | | | | | |
Sat 09/10/21 | Wythenshawe Town v Macclesfield | 0-1 | | | | | |
Sat 16/10/21 | Squires Gate v Macclesfield | 0-0 | | | | | |
Sat 23/10/21 | Macclesfield v Padiham * | 3-0 | | | | | |
Tue 02/11/21 | Macclesfield v Cheadle Heath Nomads | 3-2 | | | | | |
Tue 09/11/21 | AFC Liverpool v Macclesfield * | 1-2 | | | | | |
Fri 14/01/22 | Litherland REMYCA v Macclesfield | 1-2 | | | | | |
Sat 22/01/22 | Charnock Richard v Macclesfield | 1-1 | | | | | |
Sat 29/01/22 | Macclesfield v Skelmersdale United | 3-1 | | | | | |
Sat 05/02/22 | Padiham v Macclesfield | - | | | | | |
Tue 08/02/22 | Irlam v Macclesfield | 2-2 | | |  | | |
Sat 19/02/22 | Burscough v Macclesfield * | 0-4 | | | | | |
Tue 22/02/22 | Vauxhall Motors v Macclesfield * | 0-6 | | | | | |
Sat 26/02/22 | Runcorn Town v Macclesfield * | 0-1 | | |  | | |
Sat 05/03/22 | Macclesfield v Longridge Town * | 3-1 | | | | | |
Tue 08/03/22 | Padiham v Macclesfield | 0-2 | | | | | |
Wed 16/03/22 | Northwich Victoria v Macclesfield | 1-2 | | | | | |
Sat 19/03/22 | Macclesfield v Avro * | 6-0 | | | | | |
Tue 29/03/22 | Macclesfield v Sandbach United | 2-1 | | | | | |