| Sat 06/08/22 | Wythenshawe Town v Macclesfield | 0-2 | | | | | |
| Sat 13/08/22 | Kendal Town v Wythenshawe Town | 1-3 | | | | | |
| Sat 03/09/22 | Squires Gate v Wythenshawe Town * | 1-3 | | | | | |
| Tue 06/09/22 | Wythenshawe Town v Burscough * | 5-0 | | | | | |
| Sat 17/09/22 | Wythenshawe Town v Winsford United * | 7-0 | | | | | |
| Sat 24/09/22 | Avro v Wythenshawe Town * | 0-2 | | | | | |
| Tue 27/09/22 | Wythenshawe Town v Charnock Richard | 3-0 | | | | | |
| Sat 01/10/22 | Vauxhall Motors v Wythenshawe Town | 0-0 | | | | | |
| Sat 08/10/22 | Wythenshawe Town v Squires Gate | 6-0 | | | | | |
| Tue 11/10/22 | Wythenshawe Town v Bury AFC | 3-0 | | | | | |
| Sat 15/10/22 | Wythenshawe Town v Northwich Victoria * | 3-0 | | | | | |
| Tue 18/10/22 | Wythenshawe Town v Congleton Town * | 2-1 | | | | | |
| Sat 22/10/22 | Padiham v Wythenshawe Town * | 2-2 | | | | | |
| Tue 25/10/22 | Wythenshawe Town v FC Isle of Man | 2-2 | | | | | |
| Sat 29/10/22 | Wythenshawe Town v Prestwich Heys | 3-1 | | | | | |
| Thu 03/11/22 | Lower Breck v Wythenshawe Town | 4-0 | | | | | |
| Sat 05/11/22 | AFC Liverpool v Wythenshawe Town | 1-3 | | |  | | |
| Sat 12/11/22 | Wythenshawe Town v Eccleshill United | 2-2 | | | | | |
| Tue 15/11/22 | Wythenshawe Town v Barnoldswick Town * | 2-3 | | | | | |
| Sat 19/11/22 | Wythenshawe Town v AFC Liverpool | 5-1 | | | | | |
| Tue 22/11/22 | Wythenshawe Town v FC United of Manchester * | 3-1 | | | | | |
| Sat 26/11/22 | Ashton Athletic v Wythenshawe Town | 1-7 | | | | | |
| Sat 03/12/22 | Charnock Richard v Wythenshawe Town * | 0-1 | | | | | |
| Wed 21/12/22 | Barnoldswick Town v Wythenshawe Town | 3-2 | | | | | |
| Sat 14/01/23 | Wythenshawe Town v Ashton Athletic * | 5-0 | | | | | |
| Tue 17/01/23 | Wythenshawe Town v Vauxhall Motors * | 0-3 | | | | | |
| Tue 24/01/23 | Wythenshawe Town v Squires Gate | 1-3 | | | | | |
| Sat 28/01/23 | Longridge Town v Wythenshawe Town | 4-4 | | | | | |
| Tue 31/01/23 | Wythenshawe Town v West Didsbury & Chorlton | 0-3 | | | | | |
| Sat 04/02/23 | Winsford United v Wythenshawe Town * | 1-1 | | | | | |
| Tue 07/02/23 | Ashton United v Wythenshawe Town | 0-2 | | | | | |
| Sat 11/02/23 | Wythenshawe Town v Padiham | 0-1 | | | | | |
| Sat 18/02/23 | Wythenshawe Town v Litherland REMYCA | 3-0 | | | | | |
| Sat 25/02/23 | West Didsbury & Chorlton v Wythenshawe Town | 0-2 |  | | | | |
| Wed 01/03/23 | Bury AFC v Wythenshawe Town | 1-3 | | | | | |
| Tue 07/03/23 | Wythenshawe Town v Avro | 1-3 | | | | | |
| Sat 11/03/23 | Burscough v Wythenshawe Town * | 4-5 | | | | | |
| Sat 18/03/23 | Wythenshawe Town v AFC Liverpool | 4-0 | | | | | |
| Tue 21/03/23 | Wythenshawe Town v Kendal Town | 5-2 | | | | | |
| Sat 25/03/23 | Wythenshawe Town v Lower Breck | 2-0 | | | | | |
| Tue 04/04/23 | Prestwich Heys v Wythenshawe Town | 0-2 | | | | | |
| Mon 10/04/23 | Wythenshawe Town v Bury AFC | 3-3 | | | | | |
| Sat 15/04/23 | Congleton Town v Wythenshawe Town | 2-2 | | | | | |
| Tue 18/04/23 | Wythenshawe Town v Radcliffe | 0-3 | | | | | |
| Sat 22/04/23 | FC Isle of Man v Wythenshawe Town * | 3-1 | | | | | |
