| Sat 30/07/22 | Darwen FC v Ilkley Town | 0-3 | | | | | |
| Wed 03/08/22 | Darwen FC v Pilkington | 0-2 | | | | | |
| Sat 06/08/22 | FC St Helens v Darwen FC | 5-1 |  | | | | |
| Sat 13/08/22 | Darwen FC v Steeton | 2-1 | | | | | |
| Sat 20/08/22 | Daisy Hill v Darwen FC | 5-2 | | | | | |
| Sat 27/08/22 | Euxton Villa v Darwen FC | 2-2 | | |  | | |
| Mon 29/08/22 | Garstang v Darwen FC | 1-1 | | | | | |
| Sat 03/09/22 | AFC Blackpool v Darwen FC | 2-1 | | | | | |
| Sat 17/09/22 | Darwen FC v FC St Helens | 1-2 | | | | | |
| Sat 24/09/22 | Darwen FC v Handsworth | 2-0 | | | | | |
| Sat 01/10/22 | Atherton LR v Darwen FC | 0-1 | | | | | |
| Sat 15/10/22 | Darwen FC v Steeton | 1-5 | | | |  | |
| Sat 05/11/22 | Ashton Town v Darwen FC | 5-3 | | | | | |
| Sat 12/11/22 | Darwen FC v Thornaby | 2-1 | | | | | |
| Sat 19/11/22 | Darwen FC v Holker Old Boys | 0-1 | | | | | |
| Sat 26/11/22 | Cleator Moor Celtic v Darwen FC | 1-3 | | | | | |
| Sat 03/12/22 | Horden Community Welfare v Darwen FC | 2-0 | | | | | |
| Wed 07/12/22 | Darwen FC v South Liverpool | 2-2 | | | | | |
| Sat 28/01/23 | Runcorn Town v Darwen FC * | 0-3 | | | | | |
| Wed 01/02/23 | Darwen FC v Chadderton * | 1-3 | | | | | |
| Sat 04/02/23 | Ilkley Town v Darwen FC | 1-1 | | | | | |
| Sat 11/02/23 | Darwen FC v Garstang | 0-3 | | | | | |
| Wed 15/02/23 | Darwen FC v Cleator Moor Celtic | 5-1 | | | | | |
| Sat 18/02/23 | Steeton v Darwen FC | 3-0 | | | | | |
| Sat 25/02/23 | Darwen FC v AFC Blackpool | 2-1 | | | | | |
| Sat 04/03/23 | Chadderton v Darwen FC | 2-0 | | | | | |
| Tue 07/03/23 | Holker Old Boys v Darwen FC | 2-4 | | | | | |
| Sat 11/03/23 | Darwen FC v Runcorn Town | 6-0 | | | | | |
| Sat 18/03/23 | Bacup Borough v Darwen FC | 3-1 | | | | | |
| Sat 25/03/23 | Darwen FC v Atherton LR | 2-1 | | | | | |
