| Sat 27/07/24 | Irlam v Stockport Town | 1-2 | | | | | | |
| Tue 30/07/24 | Irlam v FC Isle of Man | 1-3 | | | | | | |
| Sat 03/08/24 | Whitchurch Alport v Irlam (CUP) | 3-0 | | | | | | |
| Sat 10/08/24 | Bury v Irlam * | 2-2 | | | | | | |
| Tue 13/08/24 | Ramsbottom United v Irlam | 3-2 | | | | | | |
| Sat 17/08/24 | Irlam v Chadderton * | 0-1 | | | | | | |
| Tue 20/08/24 | Irlam v Squires Gate * | 0-1 | | | | | | |
| Sat 24/08/24 | Glossop North End v Irlam * | 1-4 | | | | | | |
| Mon 26/08/24 | AFC Liverpool v Irlam | 3-0 | | | | | | |
| Sat 31/08/24 | Irlam v Pilkington | 3-1 | | | |  | | |
| Tue 03/09/24 | West Didsbury & Chorlton v Irlam * | 0-1 | |  | | | | |
| Sat 07/09/24 | Irlam v Charnock Richard * | 3-2 | | | | | | |
| Tue 10/09/24 | Irlam v Wythenshawe (CUP) | 0-0 | | | | | | |
| Sat 14/09/24 | Colne v Irlam | 0-2 | | | | | | |
| Tue 17/09/24 | Irlam v Barnoldswick Town | 3-0 | | | | | | |
| Sat 21/09/24 | Squires Gate v Irlam | 2-3 | | | | | | |
| Thu 26/09/24 | Lower Breck v Irlam | 2-2 | | | | | | |
| Sat 28/09/24 | Irlam v Cheadle Town | 1-3 | | | | | | |
| Tue 01/10/24 | Prestwich Heys v Irlam (CUP) | 2-2 | | | | | | |
| Sat 05/10/24 | Pilkington v Irlam | 1-3 | | | | | | |
| Tue 15/10/24 | Irlam v Glossop North End (CUP) | 3-0 | | | | | | |
| Sat 19/10/24 | Staveley Miners Welfare v Irlam (CUP) | 1-1 | | | | | | |
| Tue 22/10/24 | Irlam v Litherland REMYCA | 5-0 |  | | | | | |
| Tue 29/10/24 | FC St Helens v Irlam | 0-1 | | | | | | |
| Sat 02/11/24 | Irlam v Padiham | 1-3 | | | | | |  |
| Sat 09/11/24 | Irlam v Lower Breck | 2-2 | | | | | | |
| Tue 12/11/24 | Irlam v West Didsbury & Chorlton | 3-2 | | | | | | |
| Sat 16/11/24 | Barnoldswick Town v Irlam | 2-2 | | | | | | |
| Sat 23/11/24 | Burscough v Irlam | 1-0 | | | | | | |
| Tue 26/11/24 | Irlam v Ashton United (CUP) | 4-2 | | | | | | |
| Sat 30/11/24 | Irlam v Ramsbottom United | 1-1 | | | | | | |
| Tue 10/12/24 | Irlam v Bury | 1-1 | | | | | | |
| Sat 14/12/24 | Irlam v South Liverpool | 5-1 | | | | | | |
