| Sat 31/07/21 | Vauxhall Motors v AFC Liverpool | 1-2 | | | | | |
| Sat 07/08/21 | Padiham v AFC Liverpool | 2-3 | | | | | |
| Sat 14/08/21 | AFC Liverpool v Avro | 2-1 | | | | | |
| Tue 17/08/21 | AFC Liverpool v Lower Breck | 1-2 | | | | | |
| Fri 20/08/21 | AFC Liverpool v Bootle | 2-3 | | | | | |
| Sat 28/08/21 | AFC Liverpool v Longridge Town | 2-1 | | | | | |
| Mon 30/08/21 | Charnock Richard v AFC Liverpool | 2-2 | | | | |  |
| Sat 04/09/21 | Padiham v AFC Liverpool | 2-2 | | | | | |
| Tue 07/09/21 | Squires Gate v AFC Liverpool | 4-1 | | | | | |
| Sat 11/09/21 | AFC Liverpool v Charnock Richard | 5-3 | | | | | |
| Sat 18/09/21 | Northwich Victoria v AFC Liverpool * | 3-2 | | | | | |
| Tue 21/09/21 | Skelmersdale United v AFC Liverpool | 4-1 | | | | | |
| Sat 25/09/21 | New Mills v AFC Liverpool | 2-5 |  | |  |  | |
| Wed 29/09/21 | AFC Liverpool v Runcorn Town | 4-2 | | | | | |
| Sat 09/10/21 | AFC Liverpool v Burscough | 4-6 | | | | | |
| Sat 16/10/21 | Winsford United v AFC Liverpool | 1-4 | | | | | |
| Tue 19/10/21 | AFC Liverpool v Litherland REMYCA | 4-1 | | | | | |
| Sun 24/10/21 | AFC Liverpool v Newton Aycliffe | 2-1 | | | | | |
| Tue 26/10/21 | Prestwich Heys v AFC Liverpool | 1-0 | | | | | |
| Fri 29/10/21 | AFC Liverpool v Wythenshawe Town | 1-3 | | | | | |
| Sat 06/11/21 | AFC Liverpool v Barnoldswick Town | 1-3 | | | | | |
| Tue 09/11/21 | AFC Liverpool v Macclesfield | 1-2 | | | | | |
| Sat 13/11/21 | Irlam v AFC Liverpool | 0-4 | | | | | |
| Sat 20/11/21 | AFC Liverpool v Redcar Town | 2-0 | | | | | |
| Tue 23/11/21 | AFC Liverpool v Skelmersdale United | 1-2 | | | | | |
| Sat 04/12/21 | AFC Liverpool v Padiham | 4-2 | | | | | |
| Sun 12/12/21 | AFC Liverpool v Pilkington | 1-0 | | | | | |
| Wed 15/12/21 | Wythenshawe Town v AFC Liverpool | 2-2 | | | | | |
| Tue 28/12/21 | Lower Breck v AFC Liverpool | 2-2 | | | | | |
| Wed 05/01/22 | Litherland REMYCA v AFC Liverpool | 0-5 | | | | | |
| Sat 15/01/22 | Abbey Hey v AFC Liverpool | 2-2 | | | | | |
| Sat 22/01/22 | Barnoldswick Town v AFC Liverpool | 2-2 | | | | | |
