| Sat 31/07/21 | Vauxhall Motors v AFC Liverpool | 1-2 |  | | | | |
| Sat 07/08/21 | Vauxhall Motors v Skelmersdale United | 0-0 | | |  | | |
| Tue 10/08/21 | Skelmersdale United v Vauxhall Motors | 2-0 | | | | | |
| Sat 14/08/21 | Wythenshawe Town v Vauxhall Motors | 5-0 | | | | | |
| Tue 17/08/21 | Vauxhall Motors v Litherland REMYCA | 1-0 | | | | | |
| Sat 21/08/21 | Ashton Athletic v Vauxhall Motors | 4-5 | | | | | |
| Sat 28/08/21 | Vauxhall Motors v Skelmersdale United | 1-0 | | | | | |
| Mon 30/08/21 | Runcorn Town v Vauxhall Motors | - | | | | | |
| Fri 03/09/21 | Vauxhall Motors v Prestwich Heys | 2-1 | | | | | |
| Thu 09/09/21 | Lower Breck v Vauxhall Motors | 3-1 | | | | | |
| Sat 11/09/21 | Vauxhall Motors v Congleton Town | 0-1 | | | | | |
| Tue 14/09/21 | Macclesfield v Vauxhall Motors | 1-0 | | | | | |
| Sat 18/09/21 | Barnoldswick Town v Vauxhall Motors | 2-3 | | | | | |
| Tue 21/09/21 | Vauxhall Motors v Winsford United | 4-1 | | | | | |
| Sat 25/09/21 | Longridge Town v Vauxhall Motors | 4-0 | | | | | |
| Wed 29/09/21 | Northwich Victoria v Vauxhall Motors | 2-2 | | | | | |
| Sat 02/10/21 | Padiham v Vauxhall Motors | 1-2 | | | | | |
| Sat 13/11/21 | Vauxhall Motors v Avro * | 1-4 | | | | | |
| Tue 16/11/21 | Vauxhall Motors v Charnock Richard | 0-4 | | | | | |
| Sat 20/11/21 | Vauxhall Motors v Northwich Victoria | 1-2 | | | | | |
| Tue 23/11/21 | Vauxhall Motors v Squires Gate | 2-2 | | | | | |
| Sat 27/11/21 | Skelmersdale United v Vauxhall Motors | 5-1 | | | | | |
| Sat 18/12/21 | Vauxhall Motors v Wythenshawe Town | 3-0 | | | | | |
| Mon 27/12/21 | Congleton Town v Vauxhall Motors | 0-2 | | | | |  |
| Tue 04/01/22 | Vauxhall Motors v 1874 Northwich | 1-1 | | | | | |
| Sat 22/01/22 | Vauxhall Motors v Ashton Athletic | 0-2 | | | | | |
| Tue 25/01/22 | Vauxhall Motors v Lower Breck | 2-1 | | | | | |
| Sat 29/01/22 | AFC Liverpool v Vauxhall Motors | 0-2 | | | | | |
| Tue 01/02/22 | Winsford United v Vauxhall Motors | 1-2 | | | | | |
| Sat 05/02/22 | Vauxhall Motors v Irlam | 1-2 | | | | | |
| Wed 16/02/22 | Tranmere Rovers v Vauxhall Motors | 0-2 | | | | | |
| Tue 22/02/22 | Vauxhall Motors v Macclesfield | 0-6 | | | | | |
| Sat 26/02/22 | Vauxhall Motors v Barnoldswick Town | 2-1 | | | | | |
| Sat 05/03/22 | Charnock Richard v Vauxhall Motors | 0-3 | | | | | |
| Tue 08/03/22 | Squires Gate v Vauxhall Motors | 1-1 | | | |  | |
| Sat 12/03/22 | Avro v Vauxhall Motors | 0-1 | |  | | | |
| Tue 29/03/22 | Vauxhall Motors v Runcorn Linnets * | 0-0 | | | | | |
| Sat 02/04/22 | Litherland REMYCA v Vauxhall Motors | 2-0 | | | | | |
| Tue 12/04/22 | Vauxhall Motors v Cammell Laird 1907 * | 1-2 | | | | | |
