| 24/07/21 | Runcorn Town 3-6 1874 Northwich |
| 31/07/21 | Runcorn Town 1-2 Barnoldswick Town
Yellow Card |
| 04/08/21 | Litherland REMY 0-1 Runcorn Town |
| 07/08/21 | Barnoldswick Town 6-1 Runcorn Town
Yellow Card |
| 14/08/21 | Runcorn Town 2-4 Skelmersdale Utd
1 goal |
| 17/08/21 | Runcorn Town 1-1 Wythenshawe Town * |
| 21/08/21 | Winsford United 3-1 Runcorn Town * |
| 28/08/21 | Irlam 2-2 Runcorn Town
Yellow Card |
| 30/08/21 | Runcorn Town - Vauxhall Mtrs |
| 04/09/21 | Runcorn Town 2-2 Congleton Town |
| 07/09/21 | Ashton Athletic 2-4 Runcorn Town
1 goal , Yellow Card |
| 11/09/21 | Runcorn Town 4-1 Ashton Town
1 goal , Yellow Card |
| 14/09/21 | Runcorn Town 2-2 Lower Breck |
| 18/09/21 | Runcorn Town 2-3 Burscough
Yellow Card |
| 25/09/21 | Runcorn Town 1-4 Pilkington * |
| 29/09/21 | AFC Liverpool 4-2 Runcorn Town |
| 02/10/21 | Runcorn Town 0-2 Northwich Vics |
| 05/10/21 | Runcorn Town 2-2 Vauxhall Mtrs
Yellow Card |
| 09/10/21 | Squires Gate 0-3 Runcorn Town
1 goal , Yellow Card |
| 19/10/21 | Vauxhall Mtrs 2-1 Runcorn Town
Yellow Card |
| 23/10/21 | Runcorn Town 0-3 Winsford United |
| 26/10/21 | Longridge Town 2-2 Runcorn Town
Yellow Card |
| 30/10/21 | Avro 3-0 Runcorn Town |
| 06/11/21 | Macclesfield 2-2 Runcorn Town |
| 09/11/21 | Prestwich Heys 3-2 Runcorn Town |
| 13/11/21 | Runcorn Town 1-3 Padiham |
| 20/11/21 | Runcorn Town 1-1 Ashton Athletic |
| 27/11/21 | Charnock Richard 2-4 Runcorn Town |
