| Sat 30/07/22 | Ashton Athletic v West Didsbury & Chorlton | 1-1 | | | | |  |
| Tue 02/08/22 | Congleton Town v Ashton Athletic | 4-0 | | | | | |
| Sat 06/08/22 | Prescot Cables v Ashton Athletic | 1-1 | | | | | |
| Tue 09/08/22 | Ashton Athletic v Prescot Cables | 1-2 | | | | | |
| Sat 13/08/22 | FC Isle of Man v Ashton Athletic | 2-1 | | | | | |
| Tue 16/08/22 | Charnock Richard v Ashton Athletic | 3-2 | | | | | |
| Sat 20/08/22 | Litherland REMYCA v Ashton Athletic | 2-0 | | | | | |
| Tue 23/08/22 | Ashton Athletic v AFC Liverpool | 1-2 | | | | | |
| Sun 28/08/22 | Hallam v Ashton Athletic | 3-2 |  | | | | |
| Wed 07/09/22 | Squires Gate v Ashton Athletic | 2-1 | | |  | | |
| Sat 17/09/22 | Ashton Athletic v Northwich Victoria | 2-6 | | | | | |
| Tue 20/09/22 | Vauxhall Motors v Ashton Athletic | 1-0 | | | | | |
| Sat 24/09/22 | Prestwich Heys v Ashton Athletic | 1-0 | | | | | |
| Thu 29/09/22 | Lower Breck v Ashton Athletic | 0-1 | | | | | |
| Sat 01/10/22 | Barnoldswick Town v Ashton Athletic * | 1-2 | | | | | |
| Sat 08/10/22 | Ashton Athletic v Prestwich Heys | 0-3 | | | | | |
| Tue 11/10/22 | Kendal Town v Ashton Athletic | 4-2 | | | | | |
| Sat 15/10/22 | Ashton Athletic v Longridge Town * | 3-2 | | | | | |
| Sat 22/10/22 | Avro v Ashton Athletic | 6-2 | | | | | |
| Sat 29/10/22 | Bury AFC v Ashton Athletic | - | | | | | |
| Sat 05/11/22 | Ashton Athletic v Longridge Town | 0-1 | | | | | |
| Tue 08/11/22 | Burscough v Ashton Athletic | 1-1 | | | | | |
| Sat 12/11/22 | Padiham v Ashton Athletic | 2-0 | | | | | |
| Wed 16/11/22 | Euxton Villa v Ashton Athletic | 1-3 | | | | | |
| Sat 19/11/22 | Ashton Athletic v Euxton Villa * | 1-3 | | | | | |
| Tue 22/11/22 | Ashton Athletic v Avro | 1-2 | | | | | |
| Sat 26/11/22 | Ashton Athletic v Wythenshawe Town | 1-7 | | | | | |
| Tue 20/12/22 | West Didsbury & Chorlton v Ashton Athletic | 4-1 | | | | | |
| Mon 26/12/22 | Irlam v Ashton Athletic | 5-3 | | | | | |
| Sat 14/01/23 | Wythenshawe Town v Ashton Athletic | 5-0 | | | | | |
| Tue 17/01/23 | Radcliffe v Ashton Athletic | 1-1 | | | | | |
| Tue 24/01/23 | Longridge Town v Ashton Athletic | 2-2 | | | | | |
| Sat 28/01/23 | Ashton Athletic v Vauxhall Motors | 2-3 | | | | | |
| Tue 31/01/23 | Ashton Athletic v Winsford United | 2-1 | | | | | |
| Sat 04/02/23 | Ashton Athletic v Barnoldswick Town | 2-2 | | | | | |
| Tue 07/02/23 | Ashton Athletic v Bury AFC | 0-2 | | | | | |
| Sat 11/02/23 | AFC Liverpool v Ashton Athletic | 0-2 | | | | | |
| Sat 18/02/23 | Ashton Athletic v FC Isle of Man | 0-1 | | | | | |
| Tue 21/02/23 | Ashton Athletic v Squires Gate | 0-1 | | | | | |
| Sat 25/02/23 | Ashton Athletic v Lower Breck | 0-1 | | | | | |
| Sat 04/03/23 | Ashton Athletic v Congleton Town | 1-3 | | | | | |
| Tue 07/03/23 | Bury AFC v Ashton Athletic | 1-1 | | | | | |
| Sat 11/03/23 | Winsford United v Ashton Athletic | 3-3 | | | | | |
| Sat 18/03/23 | Ashton Athletic v Litherland REMYCA | 0-5 | | | | | |
| Sat 25/03/23 | Ashton Athletic v Charnock Richard | 2-6 | | | | | |
| Wed 29/03/23 | Ashton Athletic v Southport | 0-9 | | | | | |
| Sat 01/04/23 | Ashton Athletic v Burscough | 0-2 | | | | | |
| Mon 10/04/23 | Ashton Athletic v Irlam | 1-2 | | | | | |
| Sat 15/04/23 | Northwich Victoria v Ashton Athletic | 3-1 | | | | | |
| Sat 22/04/23 | Ashton Athletic v Kendal Town | 1-2 | | | | | |
