| Sat 26/07/25 | West Didsbury & Chorlton v Pilkington | 2-5 | | | | | | |
| Tue 29/07/25 | Glossop North End v West Didsbury & Chorlton | 1-2 | | | | | | |
| Sat 02/08/25 | Winsford United v West Didsbury & Chorlton (CUP) | 1-1 | | | | | | |
| Wed 06/08/25 | West Didsbury & Chorlton v Winsford United (CUP) | 1-1 | | | | | | |
| Sat 09/08/25 | West Didsbury & Chorlton v Euxton Villa | 3-3 | | | | | | |
| Wed 13/08/25 | West Didsbury & Chorlton v Atherton LR | 0-1 | | | | | | |
| Sat 16/08/25 | West Didsbury & Chorlton v Brighouse Town (CUP) | 1-0 | |  | | | | |
| Mon 25/08/25 | City of Liverpool v West Didsbury & Chorlton | 1-4 | | | | | | |
| Sat 30/08/25 | West Didsbury & Chorlton v Runcorn Linnets (CUP) | 0-2 | | | | | | |
| Sat 06/09/25 | South Liverpool v West Didsbury & Chorlton | 0-1 | | | | | | |
| Tue 09/09/25 | Prestwich Heys v West Didsbury & Chorlton | 2-1 | | | | | | |
| Sat 13/09/25 | West Didsbury & Chorlton v Barnoldswick Town | 4-0 | | | | | | |
| Tue 16/09/25 | Irlam v West Didsbury & Chorlton | 2-4 | | | | | | |
| Sat 20/09/25 | West Didsbury & Chorlton v Glossop North End | 1-2 | | | | | | |
| Tue 23/09/25 | Chadderton v West Didsbury & Chorlton | 1-3 | | | | | | |
| Sat 27/09/25 | West Didsbury & Chorlton v Cheadle Heath Nomads (CUP) | 4-0 | | | | | | |
| Wed 08/10/25 | West Didsbury & Chorlton v Litherland REMYCA | 3-0 | | | | | | |
| Sat 11/10/25 | West Didsbury & Chorlton v Abbey Hey (CUP) | 4-0 | | | |  | | |
| Tue 14/10/25 | Charnock Richard v West Didsbury & Chorlton | 0-1 | | | | | | |
| Sat 18/10/25 | Atherton LR v West Didsbury & Chorlton | 0-1 | | | | | |  |
| Sat 25/10/25 | West Didsbury & Chorlton v Burscough | 3-1 | | | | | | |
| Wed 29/10/25 | West Didsbury & Chorlton v Irlam | 2-5 | | | | | | |
| Sat 01/11/25 | Pilkington v West Didsbury & Chorlton | 0-5 | | | | | | |
| Tue 04/11/25 | Cheadle Town v West Didsbury & Chorlton | 0-1 | | | | | | |
