| Sat 31/07/21 | Maine Road v FC Isle of Man | 1-1 | | |  | | |
| Sat 07/08/21 | Wythenshawe Amateurs v FC Isle of Man | 2-2 |  | | | | |
| Sat 14/08/21 | Alsager Town v FC Isle of Man | 0-3 | | | | |  |
| Sat 28/08/21 | West Didsbury & Chorlton v FC Isle of Man | 3-0 | | | | | |
| Mon 30/08/21 | Abbey Hey v FC Isle of Man | 3-2 | | | | | |
| Sat 04/09/21 | Cammell Laird 1907 v FC Isle of Man | 1-6 | | | | | |
| Sat 18/09/21 | Stockport Town v FC Isle of Man | 2-3 | | | | | |
| Sat 25/09/21 | Avro v FC Isle of Man | 1-3 | | | | | |
| Tue 28/09/21 | New Mills v FC Isle of Man | 2-2 | | | | | |
| Sat 02/10/21 | Ellesmere Rangers v FC Isle of Man | 2-3 | | | | | |
| Sat 09/10/21 | Eccleshall v FC Isle of Man | 0-4 | | | | | |
| Wed 13/10/21 | Barnton v FC Isle of Man | 1-6 | | | | | |
| Sat 16/10/21 | Abbey Hulton United v FC Isle of Man | 3-8 | | | | | |
| Sat 23/10/21 | Billingham Synthonia v FC Isle of Man | 4-2 | | | | | |
| Sat 30/10/21 | FC Isle of Man v Brocton | 2-1 | | | | | |
| Tue 02/11/21 | St Martins v FC Isle of Man | 2-10 | | | | | |
| Sat 06/11/21 | FC Isle of Man v Stafford Town | 6-2 | | | | | |
| Tue 09/11/21 | Sandbach United v FC Isle of Man | 2-4 | | | | | |
| Sat 20/11/21 | FC Isle of Man v Maine Road | 2-2 | | | | | |
| Sat 04/12/21 | FC Isle of Man v Alsager Town | 4-1 | | | | | |
| Sat 11/12/21 | Rocester v FC Isle of Man | 2-2 | | | | | |
| Sat 18/12/21 | FC Isle of Man v Sandbach United | 3-5 | | | | | |
| Mon 03/01/22 | FC Isle of Man v New Mills | 2-1 | | | | | |
| Sat 08/01/22 | FC Isle of Man v Wythenshawe Amateurs | 2-0 | | | | | |
| Sat 15/01/22 | FC Isle of Man v Ellesmere Rangers | 3-0 | | | | | |
| Sat 22/01/22 | FC Isle of Man v Cheadle Town | 5-2 | | | | | |
