| Sat 24/07/21 | Runcorn Town v 1874 Northwich | 3-6 | | | | | |
| Sat 31/07/21 | Runcorn Town v Barnoldswick Town | 1-2 | | | | | |
| Wed 04/08/21 | Litherland REMYCA v Runcorn Town | 0-1 | | | | | |
| Sat 07/08/21 | Barnoldswick Town v Runcorn Town | 6-1 | | | | | |
| Sat 14/08/21 | Runcorn Town v Skelmersdale United | 2-4 | | | | | |
| Tue 17/08/21 | Runcorn Town v Wythenshawe Town | 1-1 | | | | | |
| Sat 21/08/21 | Winsford United v Runcorn Town | 3-1 | | | | | |
| Sat 28/08/21 | Irlam v Runcorn Town | 2-2 | | | | | |
| Mon 30/08/21 | Runcorn Town v Vauxhall Motors | - | | | | | |
| Sat 04/09/21 | Runcorn Town v Congleton Town | 2-2 | | | | |  |
| Tue 07/09/21 | Ashton Athletic v Runcorn Town | 2-4 | | | | | |
| Sat 11/09/21 | Runcorn Town v Ashton Town | 4-1 | | | | | |
| Tue 14/09/21 | Runcorn Town v Lower Breck | 2-2 | | | | | |
| Sat 25/09/21 | Runcorn Town v Pilkington | 1-4 | | |  | | |
| Wed 29/09/21 | AFC Liverpool v Runcorn Town | 4-2 | | | | | |
| Sat 02/10/21 | Runcorn Town v Northwich Victoria | 0-2 | | | | | |
| Tue 05/10/21 | Runcorn Town v Vauxhall Motors | 2-2 | | | | | |
| Sat 09/10/21 | Squires Gate v Runcorn Town | 0-3 | | | | | |
| Sat 16/10/21 | Runcorn Town v Charnock Richard | 1-4 | | | | | |
| Tue 19/10/21 | Vauxhall Motors v Runcorn Town | 2-1 | | | | | |
| Sat 23/10/21 | Runcorn Town v Winsford United | 0-3 | | | | | |
| Tue 26/10/21 | Longridge Town v Runcorn Town | 2-2 | | | | | |
| Sat 30/10/21 | Avro v Runcorn Town | 3-0 | | | | | |
| Sat 06/11/21 | Macclesfield v Runcorn Town | 2-2 | | | | | |
| Tue 09/11/21 | Prestwich Heys v Runcorn Town | 3-2 | | | | | |
| Sat 13/11/21 | Runcorn Town v Padiham | 1-3 | | | | | |
| Sat 20/11/21 | Runcorn Town v Ashton Athletic | 1-1 | | | | | |
| Sat 27/11/21 | Charnock Richard v Runcorn Town | 2-4 | | | | | |
