| Tue 09/09/25 | Cheadle Town v FC Isle of Man * | 3-1 | | | | | | |
| Tue 16/09/25 | AFC Liverpool v FC Isle of Man * | 5-1 | | | | | | |
| Sat 20/09/25 | Pilkington v FC Isle of Man * | 0-0 | |  | | | | |
| Wed 08/10/25 | South Liverpool v FC Isle of Man * | 3-1 | | | | | | |
| Sat 11/10/25 | Litherland REMYCA v FC Isle of Man * | 1-3 |  | | | | | |
| Sat 18/10/25 | FC Isle of Man v FC St Helens | 2-2 | | | | | | |
| Sat 01/11/25 | FC Isle of Man v Longridge Town * | 2-2 | | | | | | |
| Tue 04/11/25 | Euxton Villa v FC Isle of Man | 3-3 | | | |  | | |
| Sat 08/11/25 | FC Isle of Man v Pilkington | 1-2 | | | | | | |
| Sat 15/11/25 | FC Isle of Man v West Didsbury & Chorlton | 1-3 | | | | | | |
| Sat 22/11/25 | Longridge Town v FC Isle of Man * | 2-5 | | | | | | |
| Sat 29/11/25 | Prestwich Heys v FC Isle of Man * | 5-0 | | | | | | |
| Sat 06/12/25 | FC Isle of Man v Irlam | 2-2 | | | | | | |
| Sat 27/12/25 | FC Isle of Man v Stockport Town * | 0-4 | | | | | | |
| Sat 10/01/26 | FC Isle of Man v Burscough * | 0-1 | | | | | | |
| Wed 21/01/26 | West Didsbury & Chorlton v FC Isle of Man * | 3-2 | | | | | | |
| Wed 28/01/26 | Atherton LR v FC Isle of Man | 3-1 | | | | | | |
| Sat 21/02/26 | FC Isle of Man v Wythenshawe * | 2-1 | | | | | | |
| Sat 28/02/26 | FC Isle of Man v Abbey Hey * | 2-2 | | | | | | |
| Sat 07/03/26 | FC Isle of Man v Atherton LR | 1-5 | | | | | | |
| Tue 31/03/26 | Chadderton v FC Isle of Man * | 6-2 | | | | | | |
| Mon 06/04/26 | Stockport Town v FC Isle of Man * | 3-0 | | | | | | |
| Sat 11/04/26 | Charnock Richard v FC Isle of Man * | 5-4 | | | | | | |
| Sat 18/04/26 | Padiham v FC Isle of Man | 4-2 | | | | | | |
