| Tue 09/09/25 | Cheadle Town v FC Isle of Man | 3-1 |  | | | | | |
| Sat 13/09/25 | Burscough v Cheadle Town | 0-1 | |  | | | | |
| Tue 23/09/25 | Cheadle Town v Glossop North End * | 0-1 | | | | | | |
| Sat 27/09/25 | Cheadle Town v Glossop North End (CUP) | 3-2 | | | | | | |
| Sat 04/10/25 | Pilkington v Cheadle Town | 1-2 | | | | | | |
| Tue 07/10/25 | Wythenshawe v Cheadle Town | 1-3 | | | | | | |
| Sat 11/10/25 | Maine Road v Cheadle Town (CUP) * | 1-2 | | | | | | |
| Tue 14/10/25 | 1874 Northwich v Cheadle Town (CUP) | 0-3 | | | | | | |
| Sat 25/10/25 | Euxton Villa v Cheadle Town | 1-1 | | | | | | |
| Sat 01/11/25 | Cheadle Town v FC St Helens | 0-3 | | | | | | |
| Tue 04/11/25 | Cheadle Town v West Didsbury & Chorlton * | 0-1 | | | | | | |
| Tue 11/11/25 | Cheadle Town v Chadderton | - | | | | | | |
| Sat 15/11/25 | Charnock Richard v Cheadle Town | 5-1 | | | |  | | |
| Sat 22/11/25 | Cheadle Town v Chadderton (CUP) | 2-1 | | | | | | |
| Tue 25/11/25 | Cheadle Town v Longridge Town | 2-2 | | | | | | |
| Wed 03/12/25 | Litherland REMYCA v Cheadle Town | 4-2 | | | | | | |
| Sat 20/12/25 | FC St Helens v Cheadle Town * | 1-1 | | | | | | |
| Sat 27/12/25 | Cheadle Town v Abbey Hey | 3-1 | | | | | | |
| Tue 13/01/26 | Irlam v Cheadle Town | 6-0 | | | | | | |
| Thu 15/01/26 | Cheadle Town v Sandbach United (CUP) * | 1-1 | | | | | | |
| Sat 17/01/26 | Cheadle Town v Burscough * | 0-0 | | | | | | |
| Tue 20/01/26 | Cheadle Town v Chadderton * | 1-2 | | | | | | |
| Sat 24/01/26 | Atherton LR v Cheadle Town | 1-0 | | | | | | |
| Tue 27/01/26 | Chadderton v Cheadle Town | 3-0 | | | | | | |
| Sat 31/01/26 | Cheadle Town v South Liverpool * | 4-2 | | | | | | |
| Sat 07/02/26 | Glossop North End v Cheadle Town | 3-1 | | | | | | |
| Tue 10/02/26 | Ramsbottom United v Cheadle Town | 2-1 | | | | | | |
| Sat 14/02/26 | Burscough v Cheadle Town (CUP) | 4-0 | | | | | | |
| Sat 21/02/26 | Cheadle Town v Pilkington | 2-0 | | | | | | |
| Sat 28/02/26 | City of Liverpool v Cheadle Town | 2-2 | | | | | | |
| Tue 03/03/26 | Longridge Town v Cheadle Town | 2-0 | | | | | | |
| Sat 07/03/26 | Cheadle Town v Charnock Richard | 1-0 | | | | | | |
| Sat 14/03/26 | Barnoldswick Town v Cheadle Town | 3-1 | | | | | | |
| Tue 17/03/26 | Cheadle Town v Euxton Villa | 1-1 | | | | | |  |
| Sat 21/03/26 | FC Isle of Man v Cheadle Town | 1-2 | | | | | | |
| Tue 24/03/26 | Cheadle Town v Litherland REMYCA | 0-3 | | | | | | |
