| Sat 26/07/25 | Cheadle Town v Barnoldswick Town | 2-0 | |  | | | | |
| Tue 29/07/25 | Cheadle Town v Ramsbottom United | 1-2 | | | | | | |
| Sat 02/08/25 | Witton Albion v Cheadle Town (CUP) | 4-1 | | | | | | |
| Sat 09/08/25 | Cheadle Town v AFC Liverpool | 2-0 |  | | | | | |
| Sat 16/08/25 | Stockport Town v Cheadle Town | 2-1 | | | | | | |
| Mon 25/08/25 | Cheadle Town v Irlam | 1-2 | | | | | |  |
| Sat 30/08/25 | Prestwich Heys v Cheadle Town | 1-1 | | | | | | |
| Sat 06/09/25 | Cheadle Town v Atherton LR | 1-3 | | | | | | |
| Tue 09/09/25 | Cheadle Town v FC Isle of Man | 3-1 | | | |  | | |
| Sat 13/09/25 | Burscough v Cheadle Town | 0-1 | | | | | | |
| Sat 20/09/25 | Cheadle Town v Barnton (CUP) | 5-0 | | | | | | |
| Tue 23/09/25 | Cheadle Town v Glossop North End | 0-1 | | | | | | |
| Sat 27/09/25 | Cheadle Town v Glossop North End (CUP) | 3-2 | | | | | | |
| Sat 04/10/25 | Pilkington v Cheadle Town | 1-2 | | | | | | |
| Tue 07/10/25 | Wythenshawe v Cheadle Town | 1-3 | | | | | | |
| Sat 11/10/25 | Maine Road v Cheadle Town (CUP) | 1-2 | | | | | | |
| Tue 14/10/25 | 1874 Northwich v Cheadle Town (CUP) | 0-3 | | | | | | |
| Sun 19/10/25 | West Allotment Celtic v Cheadle Town (CUP) | 1-2 | | | | | | |
| Sat 25/10/25 | Euxton Villa v Cheadle Town | 1-1 | | | | | | |
| Sat 01/11/25 | Cheadle Town v FC St Helens | 0-3 | | | | | | |
| Tue 04/11/25 | Cheadle Town v West Didsbury & Chorlton | 0-1 | | |  | | | |
| Sat 08/11/25 | Cheadle Town v North Shields (CUP) | 0-0 | | | | | | |
| Tue 11/11/25 | Cheadle Town v Chadderton | - | | | | | | |
| Sat 15/11/25 | Charnock Richard v Cheadle Town | 5-1 | | | | | | |
| Tue 25/11/25 | Cheadle Town v Longridge Town | 2-2 | | | | | | |
| Sat 29/11/25 | AFC Liverpool v Cheadle Town | 2-2 | | | | | | |
| Wed 03/12/25 | Litherland REMYCA v Cheadle Town | 4-2 | | | | | | |
| Sat 06/12/25 | Padiham v Cheadle Town * | 1-4 | | | | | | |
