| Sat 26/07/25 | South Liverpool v Stockport Town | 0-3 | | | | | | |
| Tue 29/07/25 | Atherton LR v South Liverpool * | 1-3 | | | | | | |
| Sat 02/08/25 | Bury v South Liverpool (CUP) * | 6-0 | | | | | | |
| Sat 30/08/25 | Glossop North End v South Liverpool | 0-1 | |  | | | | |
| Sat 06/09/25 | South Liverpool v West Didsbury & Chorlton | 0-1 | | | | | | |
| Wed 10/09/25 | South Liverpool v FC St Helens * | 1-2 | | | | | | |
| Sat 13/09/25 | Prestwich Heys v South Liverpool | 3-0 | | | | | | |
| Sat 20/09/25 | Litherland REMYCA v South Liverpool | 0-3 | | | | | | |
| Wed 08/10/25 | South Liverpool v FC Isle of Man | 3-1 | | | | | | |
| Sat 11/10/25 | Longridge Town v South Liverpool | 1-1 | | | | | | |
| Wed 15/10/25 | South Liverpool v Euxton Villa | 1-1 | | | | | | |
| Sat 18/10/25 | Northallerton Town v South Liverpool (CUP) | 1-2 |  | | | | | |
| Sat 22/11/25 | South Liverpool v Irlam | 0-3 | | | | | | |
| Tue 25/11/25 | Wythenshawe v South Liverpool | 3-1 | | | | | | |
| Sat 29/11/25 | South Liverpool v Chadderton * | 2-3 | | | | | | |
| Tue 02/12/25 | FC St Helens v South Liverpool * | 3-1 | | | | | | |
| Sat 06/12/25 | Albion Sports v South Liverpool (CUP) | 0-3 | | | |  | | |
| Sat 13/12/25 | Barnoldswick Town v South Liverpool | 0-0 | | | | | | |
| Wed 17/12/25 | South Liverpool v Cheadle Town | 2-2 | | | | | | |
| Sat 20/12/25 | South Liverpool v Padiham | 1-0 | | | | | |  |
| Sat 03/01/26 | South Liverpool v Wythenshawe | 1-3 | | | | | | |
| Tue 13/01/26 | Burscough v South Liverpool * | 5-2 | | | | | | |
| Sat 17/01/26 | South Liverpool v Winsford United (CUP) | 2-5 | | | | | | |
| Sat 24/01/26 | FC Isle of Man v South Liverpool | 3-2 | | | | | | |
| Tue 10/02/26 | City of Liverpool v South Liverpool * | 1-2 | | | | |  | |
