| Sat 26/07/25 | AFC Liverpool v Irlam | 2-3 | | | | | | |
| Tue 29/07/25 | Burscough v AFC Liverpool | 1-1 |  | | |  | | |
| Sat 02/08/25 | Abbey Hey v AFC Liverpool (CUP) | 1-1 | | | | | | |
| Wed 06/08/25 | AFC Liverpool v Abbey Hey (CUP) | 2-1 | | | | | | |
| Sat 09/08/25 | Cheadle Town v AFC Liverpool | 2-0 | | | | | | |
| Tue 12/08/25 | AFC Liverpool v FC St Helens | 1-5 | | | | | | |
| Sat 16/08/25 | Witton Albion v AFC Liverpool (CUP) | 4-1 | | | | | | |
| Mon 25/08/25 | Pilkington v AFC Liverpool | 0-4 | |  | | | |  |
| Sat 30/08/25 | AFC Liverpool v City of Liverpool | 3-4 | | |  | | | |
| Sat 06/09/25 | Ramsbottom United v AFC Liverpool | 4-1 | | | | | | |
| Tue 09/09/25 | AFC Liverpool v Charnock Richard | 1-2 | | | | | | |
| Wed 01/10/25 | West Didsbury & Chorlton v AFC Liverpool * | 4-3 | | | | | | |
| Sat 04/10/25 | Atherton LR v AFC Liverpool | 3-0 | | | | | | |
| Tue 07/10/25 | AFC Liverpool v Runcorn Town (CUP) | 3-3 | | | | | | |
| Fri 10/10/25 | AFC Liverpool v Maghull (CUP) | 3-1 | | | | | | |
| Tue 14/10/25 | Padiham v AFC Liverpool | 4-0 | | | | | | |
| Sat 18/10/25 | Barnoldswick Town v AFC Liverpool (CUP) | 1-0 | | | | | | |
| Tue 21/10/25 | Charnock Richard v AFC Liverpool | 2-2 | | | | | | |
| Sat 25/10/25 | Chadderton v AFC Liverpool | 0-1 | | | | | | |
| Tue 28/10/25 | AFC Liverpool v South Liverpool | 1-1 | | | | | | |
| Wed 05/11/25 | AFC Liverpool v Prestwich Heys | 1-1 | | | | | | |
| Fri 07/11/25 | City of Liverpool v AFC Liverpool | 1-3 | | | | | | |
| Tue 11/11/25 | Euxton Villa v AFC Liverpool | 0-3 | | | | | | |
| Wed 19/11/25 | Cammell Laird 1907 v AFC Liverpool (CUP) | 1-3 | | | | | | |
| Sat 29/11/25 | AFC Liverpool v Cheadle Town | 2-2 | | | | | | |
| Sat 06/12/25 | AFC Liverpool v Abbey Hey | 3-0 | | | | | | |
